The François Jacob Institute of Biology brings together five departments and three services
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The PARi facility, located at the Institute of Cellular and Molecular Radiobiology (CEA), is a technology platform dedicated to High-Throughput and High-content Screenings (HTS & HCS) performed on cell-based assays.
Our team has the expertise and the infrastructure to setup miniaturized and automated cell-based assays, to screen libraries of biological effectors in a systematic and massively parallel fashion, to quantitate single or multiplexed reporter assays and to perform statistical analyses of large datasets (Fig. 1).
High-Throughput and High-content Screenings
All our screenings are conducted on mammalian cell-based assays, devised to report single or multiple biological functions. Additionally, some of our effector libraries (e.g. siRNAs, miRNAs...) require, by design, to work on human cells. In most cases, we rely on High content imaging for cell-based assay quantitation (Fig. 2).
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.