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The last two years in scientific news
Find here all the scientific news and highlights about the François Jacob Institute of Biology.
In a work published in Cell Reports, researchers from the SGCSR mixed research unit (IRCM) have shown that the loss of XLF (a.k.a. Cernunnos), a component of the non-homologous end-joining complex, severely alters brain development and function in mice.
Using samples collected during the Tara Oceans expeditions and sequencing "big data" generated by Genoscope, an international research team has discovered an important group of DNA viruses living among ocean surface plankton. Published in Nature, this discovery brings novel opportunities for the field of ecology and the elucidation of DNA virus evolution pathways, in the seas and beyond.
Seeking to contribute to greener chemistry and via the exploration of biodiversity, the biocatalysis team at L2BMS (UMR8030/Genoscope) has identified amine-synthesizing enzymes and shed light on the key catalytic characteristics of a number of them. Their work was recently published in Frontiers in Catalysis.
Researchers from iRCM identified new key proteins involved in the repair of single-strand DNA gaps, which occur when base lesions hamper DNA replication mechanisms.
In an article published in Environmental Pollution, a consortium of researchers from a range of institutions (CEA-Jacob/Genoscope & LSCE, University of Évry–Paris-Saclay University, Inrae, IRD, BRGM, University of Strasbourg, University of Lorraine, University of Mayotte) questions recent findings on the persistence of chlordecone contamination in French West Indies soils.
In a work published in Cells, researchers from LDG (IRCM) used human induced pluripotent stem cells to develop an in vitro model capable of reproducing the early stages of oogenesis.
Working with a model poplar line, researchers from the University of Orléans, Inrae, the University of Lorraine and CEA-Jacob's CNRGH have shown that the tree's epigenetics controls the development of ectomycorrhizas, i.e., the symbiotic relationship between the roots of certain trees and soil fungi.
In a clinical trial, the IMVA-HB/IDMIT autoimmune team (UMR-S 1184 CEA/Inserm/UPSaclay/Kremlin Bicêtre Hospital) headed by Xavier Mariette has demonstrated the therapeutic benefits of the association of rituximab and belimumab for the treatment of Sjögren syndrome.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.