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The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
In a study published in Science of the Total Environment, researchers from SIMoS (DMTS/CEA-Joliot), in collaboration with the Faculty of Pharmacy of Paris and MIRCen (CEA-Jacob) have shown for the first time in an animal model the capacity of Pinnatoxin-G, a marine neurotoxin, to cross physiological barriers to reach its molecular targets.
A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress.
In a study published in Cell Systems, the SysFate laboratory (UMR8030/Genoscope/CEA-Jacob) presented MULTILAYER, an algorithm that provides digital functional maps of biological organs or tissues.
The mechanisms that control the stability of telomeres, structures located at the ends of chromosomes, remain largely mysterious. One of them however has been decrypted by researchers from IRCM (CEA-Jacob) and I2BC (CEA-Joliot) in a work carried out in yeasts. Their results, published in Nature Communications, could help identify new therapeutic targets in human cancers.
In a study published in Molecular Therapy, LCSAT (IDMIT, CEA-Jacob) researchers present a novel, optimized, lentiviral gene therapy for β-thalassemia.
In a study published in the Journal of Clinical Investigation, researchers from IDMIT's LCSAT lab (CEA-Jacob) evaluated PPAR-γ ligands in the development of myelofibrosis.
The institutes IRIG and Jacob of the CEA's Fundamental Research Division and CEA-List joined forces to participate in KATY, a European Horizon 2020 project aimed at creating an artificial-intelligence-powered personalized medicine program.
Every year, the foundation Vaincre Alzheimer lends its support to promising projects in the battle against Alzheimer's disease. Among the six chosen this year is that of Lucile Ben Haïm of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob). Her project involves targeting astrocytes to treat depression symptoms associated with this progressive neurological disorder.
Read about the contributions of two François Jacob Institute of Biology laboratories in an article on human stem cells and their use in research published in the most recent edition of the journal L'Édition of Université Paris-Saclay. The article discusses the interest of stem cells for the development of novel disease models and potential therapies.
At the most-recent DIM ELICIT colloquium, Marco Mendoza, team leader at SysFate (UMR8030/Genoscope/CEA-Jacob), presented his project POSCOVD, financed by the special Fight-SARS-Cov2 call for projects. POSCOVD seeks to develop a large-scale COVID-19 screening methodology, building particularly upon high throughput sequencing technologies (Oxford Nanopore Sequencing).
On 12 December 2020, the schooner Tara set sail from Lorient, France, for a new two-year scientific expedition. The voyage will cover 70,000 kilometers in the South Atlantic, along the African and South-American coasts and on to Antarctica. The expedition's objective is to explore the oceanic microbiome and determine its future in the current era of climate change.Conceived by the Tara Ocean Foundation, the CNRS, the CEA and the EMBL¹, the mission will involve close to 200 scientists across 42 research structures—including Genoscope (CEA-Jacob).
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.