The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
Director : Patrick Wincker (DR, CEA)
Deputy director : Véronique de Berardinis (DR, CEA)
UMR 8030 "Metabolic Genomics" is the Genoscope's own research structure - National Sequencing Centre
Genoscope conducts its research activity within the mixt unit research UMR Metabolic Genomics (CEA/CNRS/University of Evry, Paris-Saclay), which has a staff of around 110, including 83 permanent staff.
Through various projects, both internal and conducted in the form of national or international collaborations, we explore the biodiversity of organisms by analysing their genomes, thus making a significant contribution to the global exploration of the tree of life. The unit develops interdisciplinary approaches ranging from genomics to the "supervised" evolution of micro-organisms via molecular biology, metabolic engineering, biochemistry, bioinformatics and analytical chemistry. It is involved in several international consortia such as Tara Oceans (marine metagenomic exploration) and ERGA (genomic catalogue of European biodiversity).
The unit is organised into 6 laboratories:
Recently, the emergence of new sequencing technologies has revolutionised genomics research, giving access not only to new genomes belonging to largely under-explored areas of life, but also to the global study of the biodiversity of consortia of organisms derived from environmental samples, in particular marine eukaryotes (TARA Oceans project), soil organisms (MetaTAXOMIC project), and the bacterial flora of the human gastrointestinal tract (metaHIT project).
The deluge of de novo sequence data is also accompanied by an increase in the number of genes whose functions remain completely unknown. The Genoscope UMR has therefore decided to extend the study of genome biodiversity to the study of chemical reactions carried out by living organisms, by tackling the elucidation of the function of genes with unknown functions through systematic approaches, often on a large scale, combining genomics and experimental validation (e.g. BKACE projects). The exploitation of sequencing data and the resulting identification of biological functions, particularly in biocatalysis and synthetic biology via the diversification of the chemical capacities of living organisms, has opened up new development horizons in industrial biotechnologies. From a sustainable development perspective, the unit is looking for biological solutions in chemical synthesis to contribute to the green chemistry paradigm which aims to reduce the use of fossil fuels, pollution and energy consumption.
The research is organised around several topics which are often interconnected:
The flood of de novo sequencing data is also accompanied by an increase in the number of genes whose functions remain totally unknown. Genoscope and the UMR have therefore decided to expand the study of the biodiversity of genomes to that of the chemical reactions conducted by the living worlds with four orientations:
This evolution is resolutely in line with a sustainable chemistry approach and contributes to the setup of chemistry using less fossil fuel, generating less pollution and consuming less energy.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.