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The last two years in scientific news
Find our latest scientific news, as well as coming and past seminars and PhD defences.
In an international collaboration, a team from MIRCen (CEA-Jacob) studied the properties of toxic alpha-synuclein aggregates in fixed brain samples from patients, depending on their tissue origin and the type of synucleinopathy developed.
Researchers from MIRCen (CEA-Jacob) teamed with the Frédéric Joliot Medical Imaging Center (SHFJ; CEA-Joliot) and the Henri-Mondor and Saint-Anne Hospitals to analyze neuroinflammatory response in a cohort of patients with Parkinson's disease and reported a correlation between it and disease progression. Their study, published in Parkinsonism & Related Disorders, sets a path toward the use of a radiotracer, [¹⁸F]-DPA714, for the evaluation of anti-inflammatories pertinent to the treatment of Parkinson's disease.
In an article published in NeuroImage, a CEA/CNRS/Paris-Saclay University team from MIRCen (CEA-Jacob) has described neuronal networks in the mouse lemur (Microcebus murinus), one of the smallest primates and one of the most genetically-distant from humans.
Researchers from MIRCen (CEA-Jacob) have shown that undetectable proteinaceous aggregates involved in Alzheimer's disease can be transmitted during brain surgeries in an experimental context.
The weekly MIRCen laboratory meeting is a particularly important time, at which external collaborators or students from the laboratory present their research projects.
Below is a list of speakers from external laboratories invited to speak at these meetings in the next few months.
If a PhD thesis is to be defended at the CEA at Fontenay-aux-Roses, it is possible to attend provided that a completed form is sent to the MIRCen secretary at least three days in advance.
PhD Student: Marianne Maugard.
Les patients atteints de la maladie d'Alzheimer ont des déficits du métabolisme cérébral du glucose une quinzaine d'années avant les premiers défauts cognitifs, suggérant que le métabolisme pourrait contribuer à la physiopathologie de la MA. Pour mieux comprendre les mécanismes qui relient le métabolisme énergétique et l'activité synaptique, nous nous sommes intéressés à la production de L-serine, une molécule dont la synthèse de novo dérive d'un intermédiaire de la glycolyse.
PhD Student: Séverine Maire.
Huntington’s disease (HD) is a genetic disorder caused by the expansion of a CAG repeat in the first exon of the Huntingtin gene (HTT). We propose to use trans-splicing to develop a gene therapy vector that will significantly reduce or eliminate the expression of the mutant protein while restoring a physiological level of normal HTT in cells affected by the HD mutation.
PhD Student: Jérémy Pépin.
Previous studies have shown that the metabolic profile measured in ¹H NMR spectroscopy can be altered in patients with Huntington's disease. Hypotheses involving defects in energy metabolism have been advanced to explain partially the pathophysiology of the disease. The metabolic actors could thus be biomarkers of interest. All of the results and methods implemented during this thesis show the potential of a promising MRI modality called CEST (Chemical Exchance Saturation Transfer) to identify potential biomarkers of neurodegenerative diseases.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.