The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
Find our latest scientific news, as well as coming and past seminars and PhD defences.
In a review published in Cell Metabolism, Gilles Bonvento (LMN/MIRCen/CEA-Jacob) and Juan P. Bolaños (IBFG/University of Salamanca) present the latest findings on astrocyte-neuron metabolic cooperation and how it affects brain function.
In a study published in JBC, researchers from MIRCen (CEA-Jacob) deployed a range of techniques to map the surfaces of various pathogenic alpha-synuclein aggregates, establishing thus "fingerprints" specific to each aggregate.
In an unprecedented work published in Brain, researchers from LMN (MIRCen/CEA-Jacob) showed that these abnormal tau proteins migrate from neurons to astrocytes, another type of cell within the brain, and remain toxic in the astrocytes as well.
Researchers from MIRCen (CEA-Jacob) have shown that exposure to alpha-synuclein aggregates may affect dopaminergic neuron survival in Parkinson's disease by reducing astrocyte support for them.
The weekly MIRCen laboratory meeting is a particularly important time, at which external collaborators or students from the laboratory present their research projects.
Below is a list of speakers from external laboratories invited to speak at these meetings in the next few months.
If a PhD thesis is to be defended at the CEA at Fontenay-aux-Roses, it is possible to attend provided that a completed form is sent to the MIRCen secretary at least three days in advance.
PhD Student: Marianne Maugard.
Les patients atteints de la maladie d'Alzheimer ont des déficits du métabolisme cérébral du glucose une quinzaine d'années avant les premiers défauts cognitifs, suggérant que le métabolisme pourrait contribuer à la physiopathologie de la MA. Pour mieux comprendre les mécanismes qui relient le métabolisme énergétique et l'activité synaptique, nous nous sommes intéressés à la production de L-serine, une molécule dont la synthèse de novo dérive d'un intermédiaire de la glycolyse.
PhD Student: Séverine Maire.
Huntington’s disease (HD) is a genetic disorder caused by the expansion of a CAG repeat in the first exon of the Huntingtin gene (HTT). We propose to use trans-splicing to develop a gene therapy vector that will significantly reduce or eliminate the expression of the mutant protein while restoring a physiological level of normal HTT in cells affected by the HD mutation.
PhD Student: Jérémy Pépin.
Previous studies have shown that the metabolic profile measured in ¹H NMR spectroscopy can be altered in patients with Huntington's disease. Hypotheses involving defects in energy metabolism have been advanced to explain partially the pathophysiology of the disease. The metabolic actors could thus be biomarkers of interest. All of the results and methods implemented during this thesis show the potential of a promising MRI modality called CEST (Chemical Exchance Saturation Transfer) to identify potential biomarkers of neurodegenerative diseases.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.