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Highlight | Scientific result | Neurodegenerative diseases | MRI
A preclinical multimodal imaging study conducted by the Neurodegenerative Diseases Laboratory (LMN/MIRCen) and published in Human Molecular Genetics has shed light on cerebral alterations in Huntington's disease.
Huntington's disease (HD) is a rare, hereditary, neurodegenerative disease that appears during adulthood. Currently, there are no treatments able to slow or cure the disease.
Imaging studies can contribute to that goal by furnishing more-pertinent functional information in a noninvasive manner. Among the various technologies, because of its particularly good spatial resolution and the diversity of contrasts and parameters it is able to measure, magnetic resonance imaging (MRI) is particularly well-suited for biomarker research.
An earlier glutamate metabolic imaging (gluCEST) study done in aged HD mouse models revealed the increased vulnerability of the corpus callosum, a white matter structure connecting the two cerebral hemispheres.
Aiming to better understand the role of cerebral connections and white matter in HD, researchers from MIRCen's Neurodegenerative Diseases Laboratory partnered with colleagues from the University of Grenoble and University College London to perform a study on mouse models of HD. Specifically, The looked at HD model mice aged from 2 to 18 months so as to observe disease course in a time span corresponding to young adulthood to old age in humans.
For their study, published in Human Molecular Genetics, the team developed a multimodal¹ MRI protocol to identify not only anatomic modifications within the brain but also the metabolic and structural modifications appearing as the mice aged.
1 : associating structural imaging, glutamate metabolic imaging (gluCEST), diffusion tensor imaging and magnetization transfer imaging.
Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early grey and white matter alterations | Human Molecular Genetics
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