The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
Find here all the scientific news and highlights about the François Jacob Institute of Biology.
In a study published in the Journal of Investigative Dermatology, researchers from LGRK (iRCM) identified the transcription factor MXD4/MAD4 as an element of the pathway regulating the stemness of keratinocyte precursors and their skin regeneration capacities.
In a work published in Environmental Pollution, researchers from iRCM's LDG laboratory explored the effects of exposure to two bisphenol A substitutes, BADGE and BPAF, on murine germ cells, and more specifically on oocytes and their precursors.
In a study published in Life Science Alliance, Genoscope researchers paired cell engineering and transcriptomics to explore gene regulatory programs driven by retinoic acid receptors and what role they play in neuronal differentiation.
In a study published in JCI Insight, researchers from IDMIT have demonstrated the vaccinal effectiveness of serum transfers from volunteers vaccinated against the chikungunya virus to an animal model. This work is an important step toward vaccine marketing approval, as the nature of chikungunya epidemics hampers the deployment of conventional efficacy trials.
For a study they published in Nature Communications, researchers from the CNRGH and PARCC joined forces to unprecedentedly identify genome loci associated with a risk of primary hyperaldosteronism (PHA), the most frequent cause of secondary arterial hypertension.
In a work published in Scientific Reports, researchers from IRCM, the Sup'Biotech/SEPIA partnership lab and Imagine Institute teamed to develop an in vitro, model of infertility wherein induced pluripotent stem cells generated from the erythroblasts of infertile men presenting genetic abnormalities were used to successfully generate primordial germ-like cells.
In a new collaborative study published in Scientific Reports, researchers from the Gly-CRRET Laboratory (UPEC) and SEPIA (CEA-Jacob) deployed a novel cellular model to describe the induction of the autonomous abnormal aggregation of tau protein following the expression of HS3ST2.
Researchers from IDMIT describe the course of immune & inflammatory markers and the vaginal microbiome during the menstrual cycle.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.