The François Jacob Institute of Biology brings together five departments and three services
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This platform offers methodologies, equipment and expertise of more than 20 years for the selection and engineering of nucleic acid aptamers (DNA, RNA or nuclease resistant chemistry).
The platform is open to services or collaborations with industry or academic laboratories and can identify aptamers against any type of target (small molecules, peptides, proteins, cells...). By ensuring the protection of the studies (patents, confidentiality agreement, MTA, etc.), we work with our partners in order to be as close as possible to their needs. Special care is given to the selection protocols to ensure that the aptamers best meet their end use (imaging probe, diagnostic, therapeutic, biomarker identification, compound purification ...).
Recently, we developed a software suite (PATTERNITY.seq©) to improve aptamer selection by high-throughput sequencing. The PATTERNITY.seq© suite can analyze millions of sequences to identify better aptamers in a faster way. This analysis can be carried out within the framework of services or collaborations.
In vivo biodistribution and biological effect of aptamers can then be carried out mainly by the imaging platform (optical imaging and PET).
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.