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Using mouse models, we are studying the mechanisms that regulate the fate of the GSC pool, including interactions with the testicular niche, which are involved in the maintenance or loss of tissue homeostasis after genotoxic stress such as irradiation. We are also developing a research project on the characterization of human GSCs (prepubertal and adult) in collaboration with the Histology-Embryology-Reproductive Biology-CECOS Service of the Cochin Hospital (Paris). A better understanding of the molecular pathways regulating the physiology and functional activity of GSCs should contribute to a better assessment of the genotoxic risk during accidental or medical exposure, to minimize the side effects on fertility of the therapeutic protocols used, and to study the potential of human GSCs in cell therapy of infertility.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.