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Led: Prof. Olivier Lambotte
The “Viral Infection Control” Laboratory (CoVir) is interested in understanding the mechanisms leading to the persistence of infectious pathogens in patients in the case of the AIDS virus (HIV) and its Simien equivalent (SIV).
Two major issues are discussed:
We focus in particular on adipose tissue, which contains cells "reservoirs” of HIV: CD4 T lymphocytes and macrophages. We have shown that despite antiretroviral treatment, HIV persists in adipose tissue. We are currently studying the microenvironment of infected cells and its potential role as an immuno-regulator. The presence of different immune control points is important in this context. We combine immuno-virological analyses with pharmacological studies to quantify anti-retroviral molecules in tissues and in target cells.
Through access to the primary infection cohorts and those of HIV controllers, we are able to study various parameters involved in the spontaneous control of HIV, in particular the role of CD8 T lymphocytes, their interactions with cells such as dendritic cells and interferon signatures.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.