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Scientific result | Highlight | Neurodegenerative diseases | Brain
Tauopathies are a group of neurodegenerative diseases caused by the accumulation of abnormal forms of the tau protein. In an unprecedented work made possible by the development of a novel murine model of tauopathy, researchers from
the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob/CNRS/Paris-Saclay University) and the
INSERM U1172 Alzheimer and Tauopathies Unit (Lille) teamed to show that these abnormal tau proteins migrate from neurons to astrocytes, another type of cell within the brain, and remain toxic in the astrocytes as well. Their study, published 12 April 2021 in the review
Brain, suggests that astrocytes too should be considered as therapeutic targets for tau-associated diseases
Indeed, the study published by the LMN-INSERM team in the journal Brain shows that astrocytes intervene in the pathological mechanisms of tauopathies and thus constitute potential targets for the development of novel therapies for neurodegenerative diseases.
Neuronal Tau species transfer to astrocytes and induce their loss according to Tau aggregation state I Brain
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.