The François Jacob Institute of Biology brings together five departments and three services
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The research teams of MIRCen collaborate closely with the clinical imaging center of Frédéric Joliot Hospital (SHFJ), one of the departments of the Institute of Biomedical Imaging, and the departments of neurology and neurosurgery of Henri Mondor Hospital (Paris XI University). These collaborations are developing new biomarkers and innovative treatments for neurodegenerative diseases in the framework of a translational approach.
Our team is composed of Sonia Lavisse (CEA researcher) and Véronique Gaura (neurologist and nuclear physician at the Thenon hostpital). Our team specializes in the use of functional imaging to advance towards two objectives:
This approach is made possible by the use of high-resolution imaging tools, the availability of radiotracers (cyclotron) at the SHFJ and access to cohorts of patients through collaboration with the teams at the Salpêtrière and Henri Mondor Hospitals.
In the Parkinson’s disease, markers of dopaminergic neuron loss, the key feature of this condition, have long been used to assess disease progression. We have also studied other phenomena, such as abnormalities of nicotinic receptors, of this disease. We are currently investigating whether inflammatory processes contribute to neuron cell death in this disease, using a tracer likely to provide evidence of such processes in the zones in which neuron death occurs.
We are also exploring the phenotype of subjects carrying a mutation (LRRK2) that may cause Parkinson’s disease, to determine the duration of the preclinical phase of the disease and to identify markers of this phase
These research activities are in close collaborations with the Mondor Hospital and in particular :
Pr Stéphane Palfi, head of the neurosurgery department equipped for stereotactic surgery and specializing in
biotherapy (gene transfer and cell therapy)
A clinical investigation center for biotherapy
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.