A 2-year postdoctoral scholar position, funded by the French Medical Research Foundation, is available for highly motivated and talented candidates with a Ph.D. in Neuroscience, Bioimaging or Bioengineering. You would be joining the research group of Lucile Ben Haim, at the Paris-Saclay University (France), starting at the beginning of 2024 (Jan to May).
Project
Neuron-astrocyte interactions are classically assessed through analysis of astrocyte calcium signals, overlooking transcription-factor based signaling, despite their emerging roles in health and disease. In this project, you will study how these alternative signaling cascades shape the cooperation between astrocytes and neurons and regulate complex behaviors. To do so, you will use unique astrocyte-specific viral tools to manipulate distinct transcription-factor based signaling and determine the effect on neuronal function.
In this project, at the interface between neurobiology and biomedical brain imaging, you will setup and perform: 1) Resting-state and task-based (olfactory stimulation) exam using functional magnetic resonance imaging in awake mice and 2) in vivo fiber photometry experiments to assess local neuronal function in awake behaving mice.
Skills
- Live imaging on awake mice
- Surgery (viral injections, optic fiber implantation)
- Mouse behavioral testing and analysis
Valuable assets- Interest in methodological development (MRI-compatible olfactory stimulation in awake mice)
- Skills in bioengineering or programming for data analysis
Contact
Lucile Ben Haim, Ph.D.
Team
Environment
- fMRI experiments will be performed on a
11.7T magnet at MIRCen (Fontenay-aux-Roses, France) in collaboration with Celine Baligand, Ph.D.
(Dir. Julien Valette, Ph.D.).
- Fiber photometry experiments will be performed in our new
lab at the Paris-Saclay Institute of Neuroscience (Saclay, France)
To apply
- a complete resume
- a 1-page summary of previous research and interests
- 2 letters of recommendation
As a single pdf file at
lucile.ben-haim@cnrs.fr