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Scientific result | Brain | Neurodegenerative diseases | Alzheimer's disease
Alzheimer's disease causes progressive neuronal degeneration and memory loss. MIRCen researchers have shown that the intracerebral injection of Alzheimer brain extracts into a primate model induces lesions typical of the disease and neurodegenerative processes associated with memory loss. Their work, published in Acta Neuropathologica Communications, suggests that brain tissue affected by Alzheimer's disease can transmit neurodegenerative disease.
More than a million people in France have Alzheimer's disease. This pathology results from the slow and propagative degeneration of the brain's neurons, which occurs in association with two cerebral lesions characteristic of the disease: β-amyloidosis, i.e. the accumulation of microscopic clumps of proteinaceous matter (called amyloid plaques), and tauopathy, i.e. the accumulation of abnormal tau proteins (called neurofibrillary tangles). Alzheimer's disease is associated with the aging of the brain and, in some cases, genetic factors. But can it be transmitted via contamination from one person to another?
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.