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Immuno-Hematology Research Unit - SRHI

Published on 4 July 2018

​​​​The Immuno-Hematology Research Unit created in 1991 further to the Chernobyl accident and at the request of the Haut-Commissaire à l’Energie Atomique J. TEILLAC, is in charge of the study of immune tolerance mechanisms of tissue grafts (solid and liquid), together with the immunological mechanisms for tumour escape from host surveillance. The research conducted by the SRHI since 1992 was behind the description of the function of the HLA-G molecule. The SRHI has thus established its position as the international leader on this subject, has federated numerous laboratories in several countries, and organised international conferences and workshops in 1998, 2000, 2003, 2006, 2009 and 2012 presided by E.D. Carosella.

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HLA-G locking :

Restoration of polarization​

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Inhibition of polarization perforin granules at the NK synapse by HLA-G
 
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 Research focuses on the following themes

Biology of the HLA-G  molecule: immuno-tolerant check-point, new cell and molecular targets, expression and regulatory mechanisms.

Clinical relevance: Oncology, tumoural dissemination (solid and hematological tumours), Tissue grafts.

Therapeutic applications in cancer and transplantation: cell therapy (mesenchymal stem cells, iPS), exogenous HLA-G proteins, anti-HLA-G antibodies.