François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HIF1-JMY-glioblastoma-targeting.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english When a sporadic event changes the course of Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/sporadic-event-changes-course-Alzheimer-disease.aspx In a new study performed in a mouse model and published in Acta Neuropathologica Communications, researchers from the LMN (MIRCen/CEA-Jacob) have shown that the experimental transmission of abnormal amyloid-β proteins accelerates, over time, the development of cerebral lesions and memory disorders. Brain ; Neurodegenerative diseases Researchers ; Journalists DRF Scientific result ; Highlight Brain;preclinical studies;Alzheimer's Disease;amyloid deposits; Mon, 03 Jul 2023 10:00:00 GMT XLF/Cernunnos: premature neurogenesis and delayed brain development https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/xlf-cernunnos-premature-neurogenesis-brain-development.aspx In a work published in Cell Reports, researchers from the SGCSR mixed research unit (IRCM) have shown that the loss of XLF (a.k.a. Cernunnos), a component of the non-homologous end-joining complex, severely alters brain development and function in mice. Cellular mechanisms ; Stem cells ; Stress response ; Brain ; Cell division Researchers ; general public ; Journalists IRCM Highlight ; Scientific result neural progenitor cells;DNA repair;genome stability;mitosis;NHEJ;neurogenesis;microcephaly;brain development; Fri, 21 Apr 2023 10:00:00 GMT LMN/MIRCen team wins "Équipe FRM 2023" accreditation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2023/lmn-mircen-frm-team.aspx Carole Escartin's Reactive Astrocytes team (UMR9199, Neurodegenerative Diseases Laboratory, MIRCen) has received the Équipe FRM 2023 label for its project on the role of astrocytes in the control of neuronal activity. Institutional ; Fundamental Research ; Brain ; Diagnosis and innovative treatment ; Gene and cell therapy ; Alzheimer's disease Researchers ; Journalists ; general public DRF Live in the center ; Highlight astrocytes;Alzheimer's Disease; Wed, 29 Mar 2023 10:00:00 GMT A model to better understand oogenesis and female infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/model-oogenesis-femaile-infertility.aspx In a work published in Cells, researchers from LDG (IRCM) used human induced pluripotent stem cells to develop an in vitro model capable of reproducing the early stages of oogenesis. Cellular mechanisms ; Stem cells ; Cell division Researchers ; Journalists ; general public SCSR Highlight ; Scientific result induced pluripotent stem cells;oogenesis;infertility;primordial germ cells;podoplanin;model; Thu, 16 Mar 2023 11:00:00 GMT MXD4/MAD4 : a target of interest for ex vivo stem cell preservation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/MXD4-MAD4-stel-cell-preservation.aspx In a study published in the Journal of Investigative Dermatology, researchers from LGRK (iRCM) identified the transcription factor MXD4/MAD4 as an element of the pathway regulating the stemness of keratinocyte precursors and their skin regeneration capacities. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public DRF Scientific result ; Highlight MXD4/MAD4;bioengineering;skin;skin repair;graft;stemness;cutaneous; Fri, 03 Feb 2023 11:00:00 GMT Retinoic acid receptors and neuronal differentiation: white-hat hijacking https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/retinoic-acid-receptors-neuronal-differentiation.aspx In a study published in Life Science Alliance, Genoscope researchers paired cell engineering and transcriptomics to explore gene regulatory programs driven by retinoic acid receptors and what role they play in neuronal differentiation. Brain ; Transcriptomics Researchers ; Journalists DRF Scientific result ; Highlight neuronal differentiation;retinoic acid receptor;gene regulatory programs;stemcelles;Brain; Tue, 20 Dec 2022 11:00:00 GMT An in vitro model to study infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/in-vitro-model-study-infertility.aspx In a work published in Scientific Reports, researchers from IRCM, the Sup'Biotech/SEPIA partnership lab and Imagine Institute teamed to develop an in vitro, model of infertility wherein induced pluripotent stem cells generated from the erythroblasts of infertile men presenting genetic abnormalities were used to successfully generate primordial germ-like cells. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public IRCM Highlight ; Scientific result stem cells;infertility;azoospermia; Mon, 28 Nov 2022 11:00:00 GMT IDMIT partner of the European consortium INDENEO in the framework of the Rare Disease Research Challenge Call https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/IDMIT-consortium-INDENEO-rare-disease.aspx Following the Rare Disease Research Challenge Call launched by the European Joint Programme for Rare Disease and the Rare Disease Foundation, the European INDENEO consortium project has been selected to respond to the challenge targeting the development of a system for intranasal administration of biological drugs to newborns. Among the partners of this project, IDMIT brings its expertise in preclinical trials. Brain Researchers ; Journalists ; general public Jacob Live in the center ; Highlight Brain;preclinical research;neonatology; Wed, 13 Jul 2022 10:00:00 GMT Do other primates daydream like we do? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/primates-daydream.aspx In an article published in Cell Reports, an international team including researchers from MIRCen showed that a cerebral network associated with highly elaborate cognitive capacities in humans differs from the comparable network in non-human primates. Brain ; Cognition Researchers ; Journalists ; general public DRF Scientific result ; Highlight Evolution;Brain;Primate;cognition;MRI;IRM;Imaging; Wed, 13 Apr 2022 10:00:00 GMT Gene editing to pull the plug on HLA-G: a novel antitumoral? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/gene-editing-HLAG-antitumoral.aspx As part of a international partnership, researchers from SRHI have shown that Crispr/Cas9 can be used to inactivate HLA-G expression in human cancer cell lines. Their unprecedented findings, published in Scientific Reports, suggest the possibility of novel treatment strategies to supplement current tumor immunotherapies. Cancer ; Immune system general public ; Journalists ; Researchers DRF Highlight ; Scientific result crispr-cas9;HLA-G;Cancer;immune checkpoint;Immune system;gene editing;Tumor; Tue, 22 Feb 2022 11:00:00 GMT HLA-G : a new therapeutic target in cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HLA-G-therapeutic-target-cancer.aspx In a study published in Cancer Letters, SRHI's researchers (CEA-Jacob) highlight the therapeutic value of targeting the HLA-G/IL2 immune checkpoint in clear cell renal cell carcinoma. Immune system ; Cancer Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic antibodies;HLA-G;immune checkpoint;Cancer; Tue, 24 Aug 2021 10:00:00 GMT The metabolic cooperation of astrocytes and neurons fashions brain activity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/metabolic-cooperation-astrocytes-neurons-brain-activity.aspx In a review published in Cell Metabolism, Gilles Bonvento (LMN/MIRCen/CEA-Jacob) and Juan P. Bolaños (IBFG/University of Salamanca) present the latest findings on astrocyte-neuron metabolic cooperation and how it affects brain function. Brain Researchers ; Journalists ; general public DRF Scientific result ; Highlight Brain;metabolism;astrocyte;neurons; Tue, 03 Aug 2021 10:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT The telomere mystery: a protection mechanism decrypted https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/telomere-mystery-protection-mechanism-decrypted.aspx The mechanisms that control the stability of telomeres, structures located at the ends of chromosomes, remain largely mysterious. One of them however has been decrypted by researchers from IRCM (CEA-Jacob) and I2BC (CEA-Joliot) in a work carried out in yeasts. Their results, published in Nature Communications, could help identify new therapeutic targets in human cancers. Molecular mechanisms ; DNA ; Cancer Researchers ; Journalists ; general public SCSR Highlight ; Scientific result telomere;Yeast;DNA repair;chromosome stability;modeling;genetic;Cancer;DNA; Thu, 27 May 2021 10:00:00 GMT A potential therapeutic role for PPAR-γ in myelofibrosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/potential-therapeutic-role-PPAR-gamma-myelofibrosis.aspx In a study published in the Journal of Clinical Investigation, researchers from IDMIT's LCSAT lab (CEA-Jacob) evaluated PPAR-γ ligands in the development of myelofibrosis. Diagnosis and innovative treatment ; Cancer Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight therapy;Inflammation;myeloid cells;PPAR-γ;Hematopoietic stem cells;fibrosis; Tue, 18 May 2021 10:00:00 GMT "Fingerprints" to differentiate pathogenic alpha-synuclein aggregates https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/fingerprints-pathogenic-alpha-synuclein-aggregates.aspx In a study published in JBC, researchers from MIRCen (CEA-Jacob) deployed a range of techniques to map the surfaces of various pathogenic alpha-synuclein aggregates, establishing thus "fingerprints" specific to each aggregate. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic targets;diagnosis;Parkinson;Parkinson's disease;Fingerprint;alpha-synuclein;Lewy body dementia; Wed, 12 May 2021 10:00:00 GMT Cellular prion protein at the heart of radioresistance in solid tumors https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/cellular-prion-protein-radioresistance-solid-tumors.aspx In an article published in Oncogene, researchers from LRTS and LRIG (IRCM/CEA-Jacob) have shown that an increase in the expression of cellular prion protein driven by the ATM/TAK1/JUNK signaling pathway contributes to solid tumor radioresistance. Radiotherapy ; Radiosensitivity ; Cancer Researchers ; Journalists ; general public DRF Scientific result prion;DNA damage;DNA damage response;cellular prion protein;ionizing radiation;radioresistance; Wed, 28 Apr 2021 10:00:00 GMT Tau's wanderlust in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/tau-neurodegenerative-diseases.aspx In an unprecedented work published in Brain, researchers from LMN (MIRCen/CEA-Jacob) showed that these abnormal tau proteins migrate from neurons to astrocytes, another type of cell within the brain, and remain toxic in the astrocytes as well. Neurodegenerative diseases ; Brain Researchers ; Journalists ; general public DRF Scientific result ; Highlight tau;astrocytes;Neurodegenerative disease;tauopathies;neuron; Mon, 12 Apr 2021 10:00:00 GMT Targeting HIF1α or JMY in glioblastoma: if not one why not the other? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HIF1-JMY-glioblastoma-targeting.aspx Glioblastomas are highly aggressive brain tumors with a very poor prognosis. Even with aggressive treatment, recurrence is nearly systematic. Researchers from IRCM (CEA-Jacob) have decrypted molecular mechanisms that enable treatment resistance and escape for a subpopulation of cells. Brain ; Cancer ; Stem cells Researchers ; Journalists ; general public SCSR Highlight ; Scientific result Brain;glioblastoma;Cancer;invasion;Tumor;ionizing radiations;HIF1α; Thu, 01 Apr 2021 10:00:00 GMT Astrocytes and α-synuclein in Parkinson's disease: when size matters https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/astrocytes-alpha-synuclein-Parkinson-size-matters.aspx Researchers from MIRCen (CEA-Jacob) have shown that exposure to alpha-synuclein aggregates may affect dopaminergic neuron survival in Parkinson's disease by reducing astrocyte support for them. Parkinson's disease ; Neurodegenerative diseases ; Brain Researchers ; Journalists ; general public Jacob Scientific result ; Highlight stem cells;Parkinson's disease;astrocytes;alpha-synuclein;aggregates;neuroinflammation; Mon, 29 Mar 2021 10:00:00 GMT Alpha-synuclein in Parkinson's disease : a versatile protein https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/alpha-synuclein-Parkinson-versatile-protein.aspx In an international collaboration, a team from MIRCen (CEA-Jacob) studied the properties of toxic alpha-synuclein aggregates in fixed brain samples from patients, depending on their tissue origin and the type of synucleinopathy developed. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; general public ; Journalists DRF Scientific result ; Highlight Parkinson's disease;proteolysis;enteric nervous system;Brain;alpha-synuclein;PMCA;transmission electron microscopy;protein misfolding; Thu, 18 Mar 2021 11:00:00 GMT Finally, a bit of agreement on reactive astrocytes ! https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/bit-of-agreement-reactive-astrocytes.aspx In an article entitled "Reactive astrocyte nomenclature, definitions, and future directions," published as a first consensus statement in the journal Nature Neuroscience, more than 80 international specialists, including Carole Escartin from LMN (MIRCen/CEA-Jacob) as first co-author, have established a nomenclature and definitions for reactive astrocytes. Brain ; Neurodegenerative diseases Researchers ; general public ; Journalists Highlight ; Scientific result neurons;Brain;neurodegenerative diseases;consensus;astrocytes;reactive astrocytes;Biomarkers; Mon, 15 Feb 2021 11:00:00 GMT The journal L'Édition of Université Paris-Saclay shines a light on stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/stem-cells-Edition-Universite-Paris-Saclay.aspx Read about the contributions of two François Jacob Institute of Biology laboratories in an article on human stem cells and their use in research published in the most recent edition of the journal L'Édition of Université Paris-Saclay. The article discusses the interest of stem cells for the development of novel disease models and potential therapies. Stem cells Researchers ; Journalists ; general public IRCM Live in the center stem cells; Sun, 14 Feb 2021 11:00:00 GMT PET Imaging to visualize neuroinflammation in patients with Parkinson's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/PET-imaging-visualize-neuroinflammation-patients-Parkinson-disease.aspx Researchers from MIRCen (CEA-Jacob) teamed with the Frédéric Joliot Medical Imaging Center (SHFJ; CEA-Joliot) and the Henri-Mondor and Saint-Anne Hospitals to analyze neuroinflammatory response in a cohort of patients with Parkinson's disease and reported a correlation between it and disease progression. Their study, published in Parkinsonism & Related Disorders, sets a path toward the use of a radiotracer, [¹⁸F]-DPA714, for the evaluation of anti-inflammatories pertinent to the treatment of Parkinson's disease. Parkinson's disease ; Medical imaging ; MRI ; Positron Emission Tomography ; Brain Journalists ; Researchers ; general public DRF Scientific result TSPO;brain imaging;radiotracer;neuroinflammatory processes;neuroinflammation;dopamine;Neurodegenerative disease;PET imaging;Parkinson's disease; Fri, 18 Dec 2020 11:00:00 GMT Brain function in the world's smallest primate—in 3D https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Brain-function-world-smallest-primate-3D.aspx In an article published in NeuroImage, a CEA/CNRS/Paris-Saclay University team from MIRCen (CEA-Jacob) has described neuronal networks in the mouse lemur (Microcebus murinus), one of the smallest primates and one of the most genetically-distant from humans. Brain ; Cognition ; MRI ; Medical imaging Researchers ; Journalists MIRcen Scientific result ; Highlight high field MRI;in vivo imaging;3D imaging;Brain;functional MRI;MRI;brain imaging; Wed, 16 Dec 2020 11:00:00 GMT Stealthy agents in Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Stealthy-agents-Alzheimer-disease.aspx Researchers from MIRCen (CEA-Jacob) have shown that undetectable proteinaceous aggregates involved in Alzheimer's disease can be transmitted during brain surgeries in an experimental context. Brain ; Neurodegenerative diseases ; Alzheimer's disease Researchers ; general public ; Journalists MIRcen Scientific result ; Highlight amyloid deposits;Alzheimer Disease;transmission;neurodegenerative diseases; Wed, 09 Dec 2020 11:00:00 GMT Radioactive iodine and thyroid cancer: lessons from Chernobyl and Fukushima https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radioactive-iodine-thyroid-cancer-Chernobyl-Fukushima.aspx The nuclear power plant accidents at Chernobyl and Fukushima released enormous amounts of radioactive iodine into the atmosphere. Researchers from IRCM (CEA-Jacob) propose an analysis of data on the health consequences of those accidents and particularly the effects they had on the thyroid. Radioactivity ; Radiobiology ; Radiotherapy ; Molecular mechanisms ; Cancer Researchers ; general public ; Journalists IRCM Scientific result ; Highlight molecular signature;prophylaxis;ionizing radiations;thyroid;nuclear accident;radioactive iodine;radiation-induced cancers;Cancer; Tue, 01 Dec 2020 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/FLASH-radiotherapy-treatment-acute-lymphoblastic-leukemia.aspx The LSHL (IRCM/CEA-Jacob) and the radiation oncology department of the Lausanne University Hospital teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Their results, published in the International Journal of Radiation Oncology * Biology * Physics, open new paths to treat this type of leukemia while preserving normal hematopoiesis. Cancer ; Radiotherapy Researchers ; Journalists ; general public DRF Highlight ; News ; Scientific result FLASH-RT;FLASH radiotherapy;conventional radiotherapy;Radiotherapy;Leukemia;pediatric leukemia;acute lymphoblastic leukemia; Thu, 19 Nov 2020 11:00:00 GMT Immune response: not all are equal in interferon β production https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Immune-response-not-all-equal-interferon-beta-production.aspx Researchers from IRCM (CEA-Jacob) have identified a DNA sequence polymorphism that leads to reduced production of interferon β by myeloid cells. The substitution, which is present in about 30% of the population, could affect immune response to infections and tumors. Molecular mechanisms ; Cancer ; Infectious diseases ; Immune system Researchers ; general public ; Journalists IRCM Scientific result ; Highlight radiation-induced tumor;myeloid cells;infection;immunity;regulation of gene expression;virus;polymorphism; Wed, 18 Nov 2020 11:00:00 GMT New mode of propagation identified for variant Creutzfeldt-Jakob disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/new-mode-propagation-variant-Creutzfeldt-Jakob.aspx In an article published in Acta Neuropathologica, researchers from SEPIA (CEA-Jacob) reported the discovery of a new mode of prion propagation from a localized contamination. Neurodegenerative diseases ; Brain ; Prion diseases Researchers ; Journalists SEPIA News ; Highlight ; Scientific result Creutzfeldt-Jakob;prion diseases;Creutzfeldt-Jakob disease;Neurodegenerative disease;transmissible spongiform encephalopathy;prions;Prion protein; Mon, 16 Nov 2020 11:00:00 GMT Professor François Desgrandchamps wins FRM's 2020 Jean Bernard Prize https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Professor-Desgrandchamps-wins-FRM-2020-Jean-Bernard-Prize.aspx The Jean Bernard Prize, named after the founder of the French Foundation for Medical Research (FRM), honors scientists whose research greatens public knowledge in health. This year, the FRM presented the Jean Bernard Prize to Prof. François Desgrandchamps of the Immuno-Hematology Research Unit (CEA-Jacob). Cancer ; Immune system general public ; Researchers ; Journalists DRF Live in the center ; News ; Highlight Tue, 03 Nov 2020 11:00:00 GMT Skin and ionizing radiation: sensitivity under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/skin-ionizing-radiation-sensitivity-under-surveillance.aspx In a study published in Cells, researchers from LGRK (IRCM/CEA-Jacob) showed that human skin stem cells are sensitive to low doses of genotoxic stress in the setting of active regeneration. Stem cells ; Radiobiology ; Radiosensitivity ; Radiotherapy Researchers ; Journalists DRF Scientific result ; Highlight epidermis;skin;organoids;ionizing radiation;keratinocyte stem cells;medical imaging;radiosensitivity; Wed, 07 Oct 2020 10:00:00 GMT Angiogenesis and immunity: a double target for kidney cancer treatment https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/angiogenesis-immunity-double-target-kidney-cancer-treatment.aspx Researchers from SRHI (CEA-Jacob) have demonstrated a correlation between VEGF expression and the HLA-G/IL4 immune checkpoint in the most common form of kidney cancer. Their study, published in BMC Cancer, opens new horizons for the deployment of novel therapeutic protocols. Cancer ; Immune system Researchers ; general public ; Journalists DRF News ; Scientific result Immune system;bevacizumab;therapeutic targets;HLA-G;immune checkpoint;VEGF;Angiogenesis;kidney cancer;therapeutic antibodies;Cancer; Wed, 05 Aug 2020 10:00:00 GMT The brain: a careful balance between stability and genetic variability https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/The-brain-balance-stability-variability.aspx In a study published in DNA Repair, an IRCM (CEA-Jacob) team has elucidated mechanisms through which neural stem and progenitor cells maintain genome integrity more efficaciously than other cell types. The team's work contributes to a better understanding of the high-fidelity transmission of genetic information so crucial to brain development. Brain ; DNA ; Stem cells ; Stress response Researchers ; general public ; Journalists DRF Scientific result ; Highlight adaptive response;chromosome stability;genetic diversity;neural progenitor cells;Brain;DNA repair;development;radiation;genotoxic stress;non-homologous end-joining;Neural stem cells; Mon, 20 Jul 2020 10:00:00 GMT Federating research organisms to extend the reach of preclinical imaging research https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/federating-research-organisms-to-extend-the-reach-of-preclinical-imaging-research.aspx A study on preclinical imaging involving several national research organisms (Inserm, CNRS, CEA, Universities) has produced MRI relaxometry maps for healthy rat brains. The impetus for that work is to be found in the France Life Imaging (FLI) initiative and its continuing momentum manifests today as the Small Animal Imaging Network (SAIN), which unites about ten French imaging facilities. The study, published in Frontiers in Neuroinformatics, demonstrates the feasibility of large-scale, multicenter, MRI studies in the preclinical setting. Brain ; MRI Journalists ; Researchers ; general public DRF Scientific result preclinic;relaxometry;brain imaging;mapping;MRI;in vivo imaging;Brain;neurosciences; Mon, 22 Jun 2020 10:00:00 GMT Immune checkpoints: new targets in kidney cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/immune-checkpoints-new-targets-kidney-cancer.aspx Researchers from SRHI in partnership with the MICS lab (CentraleSupélec, Paris-Saclay University) have identified new immune checkpoints as potential targets in clear cell renal cell carcinoma. The team's results, obtained by pairing statistics and biological analyses, have been published in Cancer Immunology, Immunotherapy. Cancer ; Immune system Researchers ; Journalists ; general public Jacob Scientific result immunotherapy;PD-L1;Cancer;clear cell renal cell carcinoma;HLA-G; Fri, 22 May 2020 10:00:00 GMT Combining genetic engineering and stem cells to obtain tailormade "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Combining-genetic-engineering-and-stem-cells-to-obtain-tailormade-mini-brains.aspx Researchers from the SEPIA (CEA)-Sup'Biotech partnership laboratory and the Gly-CRRET (UPEC) laboratory have developed a genetic tool for the long-term expression of proteins in human brain organoids. This work, published in Frontiers in Cellular Neuroscience, concerns the modelling of a genetic form of frontotemporal dementia, a neurodegenerative disease with a tauopathic side similar to Alzheimer's disease. Stem cells ; Neurodegenerative diseases Researchers ; Journalists Jacob Highlight ; Scientific result ; News Alzheimer Disease;neurodegenerative diseases;gene expression;stem cell;episomal plasmid;cerebral organoids; Wed, 18 Mar 2020 11:00:00 GMT Le Monde immersed in the world of "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Le-Monde-immersed-in-the-world-of-mini-brains.aspx On February 12th, a dossier on cerebral organoids was published in the Cahier Sciences et Médecine of the newspaper Le Monde: "Cerebroids: from mini-organs to maxi-powers ?" Report in the SEPIA/Sup'Biotech partnership laboratory. Neurodegenerative diseases ; Stem cells Researchers ; Journalists DRF Highlight Sun, 16 Feb 2020 11:00:00 GMT A bit of air please... https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-bit-of-air-please-.aspx ...or how small amounts of oxygen contribute to the preservation of lymphocyte progenitors in humans. In an article published in Cell Reports, researchers from LSHL (IRCM) shared new findings on the role of hypoxia in human lymphocyte differentiation. Stem cells ; Immune system Researchers ; Journalists Jacob News ; Highlight ; Scientific result hematopoietic differentiation;T lymphocytes;Hematopoietic stem cells;hypoxia;Immune system; Tue, 19 Nov 2019 11:00:00 GMT Using color to track astrocytes in high resolution https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Using-color-track-astrocytes-high-resolution.aspx Researchers from MIRCen partnered with École Polytechnique, the CNRS, Inserm and LOB to develop combinatorial labeling techniques wherein color and 3D and high-resolution imaging are used to demonstrate astrocyte plasticity during cerebral cortex development. Brain Researchers ; Journalists Jacob Scientific result ; News ; Highlight cortex;stem cell;astrocytes;Brain;neural networks;plasticity;Neural stem cells; Fri, 08 Nov 2019 11:00:00 GMT Skin graft: a new molecular target for activating stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/Skin-graft-a-new-molecular-target-for-activating-stem-cells.aspx Fundamental Research ; Health & life sciences ; Cellular mechanisms ; Stem cells ; Genomics Press release ; Highlight ; Article ; Scientific result ; Success ; Focus Wed, 23 Oct 2019 10:00:00 GMT Skin grafts: KLF4, a new target for activating skin stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Skin-grafts-KLF4-new-target-for-activating-skin-stem-cells.aspx In a study published in Nature Biomedical Engineering, a team from the Genomics and Radiobiology of Keratinopoiesis laboratory (LGRK/ IRCM) has shown that a transcription factor, KLF4, plays a key role in the proliferation of the stem cells in the epidermis. The discovery brings new therapeutic perspectives to regenerative medicine. Stem cells Researchers ; Journalists Jacob Scientific result ; Highlight ; News skin;keranocytes;stem cell;graft;cell therapy;keratinocyte stem cells; Tue, 22 Oct 2019 10:00:00 GMT NeurATRIS: "Translational Neuroscience Day " https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/Translational-Neuroscience-day.aspx NeurATRIS and Dhune are delighted to announce that the next edition of “Translational neuroscience Day: challenges and opportunities”, will be held on December 10, 2019, in Marseille and hosted by BioFit. Neurodegenerative diseases ; Brain Researchers Jacob Conference neurosciences; Wed, 16 Oct 2019 10:00:00 GMT New knowledge for cell therapies in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/New-knowledge-for-cell-therapies-in-neurodegenerative-diseases.aspx MIRCen contributed to a study that showed that the use of histocompatible neuronal grafts did not eliminate the need for immunosuppressive drugs in a primate model. Those results provide important knowledge for the clinical use of certain cell therapies under development for the treatment of neurodegenerative diseases. Brain ; Neurodegenerative diseases ; Gene and cell therapy Scientific result Wed, 09 Oct 2019 10:00:00 GMT Neurodegeneration may be induced by brains of Alzheimer patients https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Neurodegeneration-may-be-induced-by-brains-of-Alzheimer-patients.aspx MIRCen researchers have shown that the intracerebral injection of Alzheimer brain extracts into a primate induces lesions typical of the disease and neurodegenerative processes associated with memory loss. Brain ; Neurodegenerative diseases ; Alzheimer's disease Scientific result Mon, 16 Sep 2019 10:00:00 GMT Three-dimensional histology for PET quantification of brain imaging https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Three-dimensional-histology-for-PET-quantification-of-brain-imaging0830-8788.aspx With 3D histology, researchers from MIRCen highlighted, among nine methods of neuroinflammation PET quantification methods, the optimal performances of one of them. Brain ; Health & life sciences ; Positron Emission Tomography Highlight ; Scientific publications ; Scientific result Fri, 30 Aug 2019 10:00:00 GMT DNA breakage: a rescue pathway identified in Saccharomyces cerevisiae https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/DNA-breakage-a-rescue-pathway-identified-in-Saccharomyces-cerevisiae.aspx In a study recently published in the journal Molecular Cell, IRCM researchers describe the key elements of a pathway that protects chromosomes from certain radiation-induced rearrangements. Radiobiology ; Radiosensitivity ; Cancer ; DNA Researchers ; general public ; Journalists IRCM News ; Scientific publications ; Scientific result ; Highlight radiobiology;Cancer;DNA;radiosensitivity; Fri, 14 Jun 2019 10:00:00 GMT The brain: a key participant in the development of cancer? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/The-brain-a-key-participant-in-the-development-of-cancer.aspx A French team from IRCM (CEA/Inserm) recently published a study in the scientific journal Nature showing that neurons can develop within the tumoral microenvironment and thus contribute to the development of certain types of cancer. Brain ; Cancer ; Health & life sciences ; Cellular mechanisms Researchers ; Journalists ; general public Paris-Saclay Scientific publications ; Scientific result ; News health;Cancer;neural network;Brain;neuron;neurosciences; Fri, 17 May 2019 10:00:00 GMT 8th international Conference on HLA-G https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/8th-international-Conference-on-HLA-G.aspx The 8th International Conference on HLA-G will take place at the Ministry of Health and Solidarity (Ministère de la Santé et des Solidarités) in Paris on 8, 9 and 10 July 2019. Cancer ; Health & life sciences ; Immune system Researchers ; Journalists Agenda ; News ; Institute ; Highlight ; Conference ; Seminars Cancer;HLA-G;Immune system; Fri, 03 May 2019 10:00:00 GMT Astrocytic mitochondria help you remember https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Astrocytic-mitochondria-memory.aspx With help from MIRCen, an international team has shown that the mitochondria of astrocytes (neuron support cells) intervene in the regulation of memory. Brain ; Neurodegenerative diseases ; Cellular mechanisms general public ; Researchers ; Journalists Paris-Saclay Scientific result neurons;mitochondria;astrocytes;memory;Brain;neurosciences; Thu, 28 Mar 2019 11:00:00 GMT THERANEXUS set to receive €6.2 million in funding from the French Investments for the Future program https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/THERANEXUS-set-to-receive-€6-2-million-in-funding-from-the-French-Investments-.aspx Health & life sciences ; Brain Jacob Press release ; Focus Wed, 30 Jan 2019 11:00:00 GMT "Mini-brains" for research on Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/mini-brains-research-Alzheimer-disease.aspx A partnership between the François Jacob Institute of Biology/CEA, The Frédéric Joliot Institute for Life Sciences/CEA and CellTechs (a Sup'Biotech lab) has led to a new approach for modeling Alzheimer's disease in vitro. Health & life sciences ; Brain ; Alzheimer's disease MIRcen Scientific result Brain;Alzheimer; Mon, 14 Jan 2019 11:00:00 GMT Alzheimer’s: identification of potential target protein aggregates for treating the disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/alzheimer-identification-potential-target-protein-aggregates-disease.aspx The propagation of tau protein aggregates in the brain contributes to the progression of Alzheimer’s disease. Researchers at the Neurodegenerative Diseases Laboratory: mechanisms, therapies, imaging (CNRS/CEA/Université Paris-Sud, MIRCen), working in collaboration with the Ecole Normale Supérieure, Sorbonne University and Inserm, have just identified the targets of these aggregates. Alzheimer's disease ; Brain ; Health & life sciences general public ; Institutions ; Journalists ; Researchers ; Higher education DRF Press release CNRS;inserm; Thu, 10 Jan 2019 11:00:00 GMT Alzheimer's disease: blocking reactive astrocytes to help neurons https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Alzheimer-disease-blocking-reactive-astrocytes-help-neurons.aspx Researchers from MIRCen have shown that inhibiting reactive astrocytes is beneficial for certain characteristics of Alzheimer's disease. Their results could lead to novel therapies that act upon astrocytes to improve neuron function. Brain ; Gene and cell therapy ; Alzheimer's disease ; Cellular mechanisms Paris-Saclay Scientific result Alzheimer;astrocytes;neuron; Mon, 29 Oct 2018 11:00:00 GMT Can eating less extend life? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/eating-less-extend-life.aspx The François Jacob Institute of Biology participated in a study showing that caloric restriction greatly increases longevity in a small primate called the mouse lemur. Brain ; Health & life sciences Fontenay-aux-Roses Scientific result caloric restriction;gray matter; Fri, 20 Apr 2018 10:00:00 GMT Theranexus signs partnership with the Collège de France https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2018/Theranexus-partnership-College-de-France.aspx Theranexus, a CEA-born biopharmaceutical company, signs a three-year research partnership agreement with the Collège de France. Pharmacology ; Brain Researchers ; general public ; Journalists Jacob Academic partnerships glial cells;narcolepsy;psychotropic medications; Thu, 15 Mar 2018 11:00:00 GMT A blood test to predict bladder cancer recurrence https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/blood-test-bladder-cancer.aspx In a 100-patient cohort at the Saint-Louis Hospital in Paris, researchers from the CEA and Paris-Diderot University have shown that the rate of certain immune cells in the blood is predictive of bladder cancer recurrence or progression. They suggest using their patented blood test to predict recurrence in other types of cancers. Cancer ; Biomarkers Researchers ; general public ; Journalists Jacob Scientific result Tue, 18 Jul 2017 10:00:00 GMT Chronic Myeloid Leukemia: a New Therapy Proves Successful https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Chronic-Myeloid-Leukemia-a-New-Therapy-Proves-Successful.aspx In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells—an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. Cancer ; Gene and cell therapy general public ; Journalists ; Researchers Jacob Scientific result Tue, 28 Feb 2017 11:00:00 GMT