François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/skin-ionizing-radiation-sensitivity-under-surveillance.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english XLF/Cernunnos: premature neurogenesis and delayed brain development https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/xlf-cernunnos-premature-neurogenesis-brain-development.aspx In a work published in Cell Reports, researchers from the SGCSR mixed research unit (IRCM) have shown that the loss of XLF (a.k.a. Cernunnos), a component of the non-homologous end-joining complex, severely alters brain development and function in mice. Cellular mechanisms ; Stem cells ; Stress response ; Brain ; Cell division Researchers ; general public ; Journalists IRCM Highlight ; Scientific result neural progenitor cells;DNA repair;genome stability;mitosis;NHEJ;neurogenesis;microcephaly;brain development; Fri, 21 Apr 2023 10:00:00 GMT A model to better understand oogenesis and female infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/model-oogenesis-femaile-infertility.aspx In a work published in Cells, researchers from LDG (IRCM) used human induced pluripotent stem cells to develop an in vitro model capable of reproducing the early stages of oogenesis. Cellular mechanisms ; Stem cells ; Cell division Researchers ; Journalists ; general public SCSR Highlight ; Scientific result induced pluripotent stem cells;oogenesis;infertility;primordial germ cells;podoplanin;model; Thu, 16 Mar 2023 11:00:00 GMT MXD4/MAD4 : a target of interest for ex vivo stem cell preservation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/MXD4-MAD4-stel-cell-preservation.aspx In a study published in the Journal of Investigative Dermatology, researchers from LGRK (iRCM) identified the transcription factor MXD4/MAD4 as an element of the pathway regulating the stemness of keratinocyte precursors and their skin regeneration capacities. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public DRF Scientific result ; Highlight MXD4/MAD4;bioengineering;skin;skin repair;graft;stemness;cutaneous; Fri, 03 Feb 2023 11:00:00 GMT An in vitro model to study infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/in-vitro-model-study-infertility.aspx In a work published in Scientific Reports, researchers from IRCM, the Sup'Biotech/SEPIA partnership lab and Imagine Institute teamed to develop an in vitro, model of infertility wherein induced pluripotent stem cells generated from the erythroblasts of infertile men presenting genetic abnormalities were used to successfully generate primordial germ-like cells. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public IRCM Highlight ; Scientific result stem cells;infertility;azoospermia; Mon, 28 Nov 2022 11:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT Cellular prion protein at the heart of radioresistance in solid tumors https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/cellular-prion-protein-radioresistance-solid-tumors.aspx In an article published in Oncogene, researchers from LRTS and LRIG (IRCM/CEA-Jacob) have shown that an increase in the expression of cellular prion protein driven by the ATM/TAK1/JUNK signaling pathway contributes to solid tumor radioresistance. Radiotherapy ; Radiosensitivity ; Cancer Researchers ; Journalists ; general public DRF Scientific result prion;DNA damage;DNA damage response;cellular prion protein;ionizing radiation;radioresistance; Wed, 28 Apr 2021 10:00:00 GMT Targeting HIF1α or JMY in glioblastoma: if not one why not the other? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HIF1-JMY-glioblastoma-targeting.aspx Glioblastomas are highly aggressive brain tumors with a very poor prognosis. Even with aggressive treatment, recurrence is nearly systematic. Researchers from IRCM (CEA-Jacob) have decrypted molecular mechanisms that enable treatment resistance and escape for a subpopulation of cells. Brain ; Cancer ; Stem cells Researchers ; Journalists ; general public SCSR Highlight ; Scientific result Brain;glioblastoma;Cancer;invasion;Tumor;ionizing radiations;HIF1α; Thu, 01 Apr 2021 10:00:00 GMT The journal L'Édition of Université Paris-Saclay shines a light on stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/stem-cells-Edition-Universite-Paris-Saclay.aspx Read about the contributions of two François Jacob Institute of Biology laboratories in an article on human stem cells and their use in research published in the most recent edition of the journal L'Édition of Université Paris-Saclay. The article discusses the interest of stem cells for the development of novel disease models and potential therapies. Stem cells Researchers ; Journalists ; general public IRCM Live in the center stem cells; Sun, 14 Feb 2021 11:00:00 GMT A new molecular signature to better identify radiosensitive patients https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/new-molecular-signature-identify-radiosensitive-patients.aspx A study co-piloted by researchers from LGRK (IRCM/CEA-Jacob) and Claude Bernard Lyon 1 University and performed on cells from patients who experienced severe adverse effects after radiation therapy enabled the identification of a novel molecular signature of excessive radiosensitivity in healthy tissues. Radiotherapy ; Radiosensitivity Researchers ; general public ; Journalists DRF Scientific result ; Highlight radiosensitivity;Radiation Therapy;NFATC2;fibroblasts;skin;DNA repair;radioresistance; Wed, 03 Feb 2021 11:00:00 GMT Radioactive iodine and thyroid cancer: lessons from Chernobyl and Fukushima https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radioactive-iodine-thyroid-cancer-Chernobyl-Fukushima.aspx The nuclear power plant accidents at Chernobyl and Fukushima released enormous amounts of radioactive iodine into the atmosphere. Researchers from IRCM (CEA-Jacob) propose an analysis of data on the health consequences of those accidents and particularly the effects they had on the thyroid. Radioactivity ; Radiobiology ; Radiotherapy ; Molecular mechanisms ; Cancer Researchers ; general public ; Journalists IRCM Scientific result ; Highlight molecular signature;prophylaxis;ionizing radiations;thyroid;nuclear accident;radioactive iodine;radiation-induced cancers;Cancer; Tue, 01 Dec 2020 11:00:00 GMT FLASH radiotherapy for the treatment of acute lymphoblastic leukemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/FLASH-radiotherapy-treatment-acute-lymphoblastic-leukemia.aspx The LSHL (IRCM/CEA-Jacob) and the radiation oncology department of the Lausanne University Hospital teamed to compare FLASH radiotherapy to conventional radiotherapy in the setting of acute lymphoblastic leukemia. Their results, published in the International Journal of Radiation Oncology * Biology * Physics, open new paths to treat this type of leukemia while preserving normal hematopoiesis. Cancer ; Radiotherapy Researchers ; Journalists ; general public DRF Highlight ; News ; Scientific result FLASH-RT;FLASH radiotherapy;conventional radiotherapy;Radiotherapy;Leukemia;pediatric leukemia;acute lymphoblastic leukemia; Thu, 19 Nov 2020 11:00:00 GMT Skin and ionizing radiation: sensitivity under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/skin-ionizing-radiation-sensitivity-under-surveillance.aspx In a study published in Cells, researchers from LGRK (IRCM/CEA-Jacob) showed that human skin stem cells are sensitive to low doses of genotoxic stress in the setting of active regeneration. Stem cells ; Radiobiology ; Radiosensitivity ; Radiotherapy Researchers ; Journalists DRF Scientific result ; Highlight epidermis;skin;organoids;ionizing radiation;keratinocyte stem cells;medical imaging;radiosensitivity; Wed, 07 Oct 2020 10:00:00 GMT The brain: a careful balance between stability and genetic variability https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/The-brain-balance-stability-variability.aspx In a study published in DNA Repair, an IRCM (CEA-Jacob) team has elucidated mechanisms through which neural stem and progenitor cells maintain genome integrity more efficaciously than other cell types. The team's work contributes to a better understanding of the high-fidelity transmission of genetic information so crucial to brain development. Brain ; DNA ; Stem cells ; Stress response Researchers ; general public ; Journalists DRF Scientific result ; Highlight adaptive response;chromosome stability;genetic diversity;neural progenitor cells;Brain;DNA repair;development;radiation;genotoxic stress;non-homologous end-joining;Neural stem cells; Mon, 20 Jul 2020 10:00:00 GMT Combining genetic engineering and stem cells to obtain tailormade "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Combining-genetic-engineering-and-stem-cells-to-obtain-tailormade-mini-brains.aspx Researchers from the SEPIA (CEA)-Sup'Biotech partnership laboratory and the Gly-CRRET (UPEC) laboratory have developed a genetic tool for the long-term expression of proteins in human brain organoids. This work, published in Frontiers in Cellular Neuroscience, concerns the modelling of a genetic form of frontotemporal dementia, a neurodegenerative disease with a tauopathic side similar to Alzheimer's disease. Stem cells ; Neurodegenerative diseases Researchers ; Journalists Jacob Highlight ; Scientific result ; News Alzheimer Disease;neurodegenerative diseases;gene expression;stem cell;episomal plasmid;cerebral organoids; Wed, 18 Mar 2020 11:00:00 GMT Le Monde immersed in the world of "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Le-Monde-immersed-in-the-world-of-mini-brains.aspx On February 12th, a dossier on cerebral organoids was published in the Cahier Sciences et Médecine of the newspaper Le Monde: "Cerebroids: from mini-organs to maxi-powers ?" Report in the SEPIA/Sup'Biotech partnership laboratory. Neurodegenerative diseases ; Stem cells Researchers ; Journalists DRF Highlight Sun, 16 Feb 2020 11:00:00 GMT Radiation and oxidative stress: helping blood stem cells avoid a rough day https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Radiation-and-oxidative-stress-helping-blood-stem-cells-avoid-a-rough-day.aspx An IRCM team (CEA/Inserm) has shown that exposure to low-dose ionizing radiation causes functional losses in human hematopoietic stem cells. Their results, published in Haematologica, suggest the need for complementary care during radiation therapy regimens. Radiotherapy ; Radiosensitivity Researchers ; Journalists DRF Highlight ; News ; Scientific result Radiotherapy;oxydative stress;hematopoiesis;Hematopoietic stem cells; Fri, 24 Jan 2020 11:00:00 GMT A bit of air please... https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-bit-of-air-please-.aspx ...or how small amounts of oxygen contribute to the preservation of lymphocyte progenitors in humans. In an article published in Cell Reports, researchers from LSHL (IRCM) shared new findings on the role of hypoxia in human lymphocyte differentiation. Stem cells ; Immune system Researchers ; Journalists Jacob News ; Highlight ; Scientific result hematopoietic differentiation;T lymphocytes;Hematopoietic stem cells;hypoxia;Immune system; Tue, 19 Nov 2019 11:00:00 GMT QST-NIRS seminar: CEA and IRSN presented their research activities https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/QST-NIRS-seminar-CEA-and-IRSN-presented-their-research-activities.aspx CEA and IRSN presented their research activities in radiobiology, radiopathology, epidemiology and dosimetry in a tripartite seminar organized on 28-29 October 2019 by the QST-NIRS in Chiba, Japan. Radiobiology Researchers ; Journalists DRF News ; Colloquium radiobiology; Wed, 30 Oct 2019 09:14:59 GMT Skin graft: a new molecular target for activating stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/Skin-graft-a-new-molecular-target-for-activating-stem-cells.aspx Fundamental Research ; Health & life sciences ; Cellular mechanisms ; Stem cells ; Genomics Press release ; Highlight ; Article ; Scientific result ; Success ; Focus Wed, 23 Oct 2019 10:00:00 GMT Skin grafts: KLF4, a new target for activating skin stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Skin-grafts-KLF4-new-target-for-activating-skin-stem-cells.aspx In a study published in Nature Biomedical Engineering, a team from the Genomics and Radiobiology of Keratinopoiesis laboratory (LGRK/ IRCM) has shown that a transcription factor, KLF4, plays a key role in the proliferation of the stem cells in the epidermis. The discovery brings new therapeutic perspectives to regenerative medicine. Stem cells Researchers ; Journalists Jacob Scientific result ; Highlight ; News skin;keranocytes;stem cell;graft;cell therapy;keratinocyte stem cells; Tue, 22 Oct 2019 10:00:00 GMT DNA breakage: a rescue pathway identified in Saccharomyces cerevisiae https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/DNA-breakage-a-rescue-pathway-identified-in-Saccharomyces-cerevisiae.aspx In a study recently published in the journal Molecular Cell, IRCM researchers describe the key elements of a pathway that protects chromosomes from certain radiation-induced rearrangements. Radiobiology ; Radiosensitivity ; Cancer ; DNA Researchers ; general public ; Journalists IRCM News ; Scientific publications ; Scientific result ; Highlight radiobiology;Cancer;DNA;radiosensitivity; Fri, 14 Jun 2019 10:00:00 GMT DNA repair: the importance of proximity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/DNA-repair-importance-proximity.aspx Researchers at IRCM have shown that certain mechanisms involved in DNA repair are influenced by the intramolecular and intranuclear spatial organization of the macromolecule. Fundamental Research ; Radiobiology ; DNA Scientific result genotoxic stress; Wed, 11 Apr 2018 10:00:00 GMT The yin and yang of low-dose irradiation on hematopoiesis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Yin-Yang-low-dose-irradiation-hematopoiesis.aspx Researchers at the CEA's François Jacob Institute of Biology and their partners show that exposure to low-dose irradiation causes a loss of function in hematopoietic stem cells. Which is bad. And good. Radiobiology ; Low doses Researchers ; Journalists ; general public Fontenay-aux-Roses Scientific result Fri, 29 Sep 2017 10:00:00 GMT