François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Molecular- chaperones-tauopathies-double-edged-sword.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english When a sporadic event changes the course of Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/sporadic-event-changes-course-Alzheimer-disease.aspx In a new study performed in a mouse model and published in Acta Neuropathologica Communications, researchers from the LMN (MIRCen/CEA-Jacob) have shown that the experimental transmission of abnormal amyloid-β proteins accelerates, over time, the development of cerebral lesions and memory disorders. Brain ; Neurodegenerative diseases Researchers ; Journalists DRF Scientific result ; Highlight Brain;preclinical studies;Alzheimer's Disease;amyloid deposits; Mon, 03 Jul 2023 10:00:00 GMT An Alzheimer's model to study the propagation of the pathological forms of tau https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/Alzheimer-propagation-forms-pathological-Tau-.aspx In an article published in Neurobiology of Disease, researchers from MIRCen's Neurodegenerative Diseases Laboratory present a novel model of Alzheimer's disease that enables the study of tauopathy inter-neuronal propagation mechanisms, the identification of new therapeutic targets and the exploration of new treatments. Neurodegenerative diseases ; Alzheimer's disease ; Cellular mechanisms Researchers ; general public ; Journalists MIRcen Highlight ; Scientific result Alzheimer Disease;Cellular biology;tau protein;AAV; Fri, 16 Jun 2023 10:00:00 GMT LMN/MIRCen team wins "Équipe FRM 2023" accreditation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2023/lmn-mircen-frm-team.aspx Carole Escartin's Reactive Astrocytes team (UMR9199, Neurodegenerative Diseases Laboratory, MIRCen) has received the Équipe FRM 2023 label for its project on the role of astrocytes in the control of neuronal activity. Institutional ; Fundamental Research ; Brain ; Diagnosis and innovative treatment ; Gene and cell therapy ; Alzheimer's disease Researchers ; Journalists ; general public DRF Live in the center ; Highlight astrocytes;Alzheimer's Disease; Wed, 29 Mar 2023 10:00:00 GMT Tauopathy in Alzheimer's disease: a new target https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/tauopathy-Alzheimer-disease-new-target.aspx In a new collaborative study published in Scientific Reports, researchers from the Gly-CRRET Laboratory (UPEC) and SEPIA (CEA-Jacob) deployed a novel cellular model to describe the induction of the autonomous abnormal aggregation of tau protein following the expression of HS3ST2. Neurodegenerative diseases Researchers ; Journalists ; general public DRF Scientific result ; Highlight Alzheimer;Alzheimer's Disease;tau protein;pebv;cellular and molecular imaging;Cellular biology; Fri, 04 Nov 2022 11:00:00 GMT Preclinical multimodal imaging and Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/preclinical-multimodal-imaging-huntington-disease.aspx A preclinical multimodal imaging study conducted by the Neurodegenerative Diseases Laboratory (LMN/MIRCen) and published in Human Molecular Genetics has shed light on cerebral alterations in Huntington's disease. Neurodegenerative diseases ; MRI Researchers ; Journalists ; general public DRF Highlight ; Scientific result gluCEST;Imaging;huntington;Brain;brain imaging;cerebral; Tue, 12 Apr 2022 10:00:00 GMT The beneficial role of reactive astrocytes in Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/huntington-disease-reactive-astrocytes.aspx In a new study published in Brain, researchers MIRCen used mouse models of Huntington's disease to show that stimulating reactive astrocyte formation favors the elimination of mutant huntingtin protein, reducing both the quantity and size of the aggregates. Neurodegenerative diseases ; Diagnosis and innovative treatment Researchers ; Journalists ; general public MIRcen Scientific result ; Highlight huntington;neuron;reactive astrocytes;astrocytes;JAK2-STAT3;huntingtin;preclinical research; Mon, 28 Mar 2022 10:00:00 GMT "Fingerprints" to differentiate pathogenic alpha-synuclein aggregates https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/fingerprints-pathogenic-alpha-synuclein-aggregates.aspx In a study published in JBC, researchers from MIRCen (CEA-Jacob) deployed a range of techniques to map the surfaces of various pathogenic alpha-synuclein aggregates, establishing thus "fingerprints" specific to each aggregate. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic targets;diagnosis;Parkinson;Parkinson's disease;Fingerprint;alpha-synuclein;Lewy body dementia; Wed, 12 May 2021 10:00:00 GMT Tau's wanderlust in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/tau-neurodegenerative-diseases.aspx In an unprecedented work published in Brain, researchers from LMN (MIRCen/CEA-Jacob) showed that these abnormal tau proteins migrate from neurons to astrocytes, another type of cell within the brain, and remain toxic in the astrocytes as well. Neurodegenerative diseases ; Brain Researchers ; Journalists ; general public DRF Scientific result ; Highlight tau;astrocytes;Neurodegenerative disease;tauopathies;neuron; Mon, 12 Apr 2021 10:00:00 GMT Astrocytes and α-synuclein in Parkinson's disease: when size matters https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/astrocytes-alpha-synuclein-Parkinson-size-matters.aspx Researchers from MIRCen (CEA-Jacob) have shown that exposure to alpha-synuclein aggregates may affect dopaminergic neuron survival in Parkinson's disease by reducing astrocyte support for them. Parkinson's disease ; Neurodegenerative diseases ; Brain Researchers ; Journalists ; general public Jacob Scientific result ; Highlight stem cells;Parkinson's disease;astrocytes;alpha-synuclein;aggregates;neuroinflammation; Mon, 29 Mar 2021 10:00:00 GMT Alpha-synuclein in Parkinson's disease : a versatile protein https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/alpha-synuclein-Parkinson-versatile-protein.aspx In an international collaboration, a team from MIRCen (CEA-Jacob) studied the properties of toxic alpha-synuclein aggregates in fixed brain samples from patients, depending on their tissue origin and the type of synucleinopathy developed. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; general public ; Journalists DRF Scientific result ; Highlight Parkinson's disease;proteolysis;enteric nervous system;Brain;alpha-synuclein;PMCA;transmission electron microscopy;protein misfolding; Thu, 18 Mar 2021 11:00:00 GMT Lucile Ben Haïm wins support from Vaincre Alzheimer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/Lucile-Ben-Haim-wins-support-from-Vaincre-Alzheimer.aspx Every year, the foundation Vaincre Alzheimer lends its support to promising projects in the battle against Alzheimer's disease. Among the six chosen this year is that of Lucile Ben Haïm of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob). Her project involves targeting astrocytes to treat depression symptoms associated with this progressive neurological disorder. Alzheimer's disease Researchers ; Journalists ; general public Live in the center astrocyte;Alzheimer;Depression;reactive astrocytes; Wed, 17 Feb 2021 11:00:00 GMT Finally, a bit of agreement on reactive astrocytes ! https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/bit-of-agreement-reactive-astrocytes.aspx In an article entitled "Reactive astrocyte nomenclature, definitions, and future directions," published as a first consensus statement in the journal Nature Neuroscience, more than 80 international specialists, including Carole Escartin from LMN (MIRCen/CEA-Jacob) as first co-author, have established a nomenclature and definitions for reactive astrocytes. Brain ; Neurodegenerative diseases Researchers ; general public ; Journalists Highlight ; Scientific result neurons;Brain;neurodegenerative diseases;consensus;astrocytes;reactive astrocytes;Biomarkers; Mon, 15 Feb 2021 11:00:00 GMT PET Imaging to visualize neuroinflammation in patients with Parkinson's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/PET-imaging-visualize-neuroinflammation-patients-Parkinson-disease.aspx Researchers from MIRCen (CEA-Jacob) teamed with the Frédéric Joliot Medical Imaging Center (SHFJ; CEA-Joliot) and the Henri-Mondor and Saint-Anne Hospitals to analyze neuroinflammatory response in a cohort of patients with Parkinson's disease and reported a correlation between it and disease progression. Their study, published in Parkinsonism & Related Disorders, sets a path toward the use of a radiotracer, [¹⁸F]-DPA714, for the evaluation of anti-inflammatories pertinent to the treatment of Parkinson's disease. Parkinson's disease ; Medical imaging ; MRI ; Positron Emission Tomography ; Brain Journalists ; Researchers ; general public DRF Scientific result TSPO;brain imaging;radiotracer;neuroinflammatory processes;neuroinflammation;dopamine;Neurodegenerative disease;PET imaging;Parkinson's disease; Fri, 18 Dec 2020 11:00:00 GMT Stealthy agents in Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Stealthy-agents-Alzheimer-disease.aspx Researchers from MIRCen (CEA-Jacob) have shown that undetectable proteinaceous aggregates involved in Alzheimer's disease can be transmitted during brain surgeries in an experimental context. Brain ; Neurodegenerative diseases ; Alzheimer's disease Researchers ; general public ; Journalists MIRcen Scientific result ; Highlight amyloid deposits;Alzheimer Disease;transmission;neurodegenerative diseases; Wed, 09 Dec 2020 11:00:00 GMT New mode of propagation identified for variant Creutzfeldt-Jakob disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/new-mode-propagation-variant-Creutzfeldt-Jakob.aspx In an article published in Acta Neuropathologica, researchers from SEPIA (CEA-Jacob) reported the discovery of a new mode of prion propagation from a localized contamination. Neurodegenerative diseases ; Brain ; Prion diseases Researchers ; Journalists SEPIA News ; Highlight ; Scientific result Creutzfeldt-Jakob;prion diseases;Creutzfeldt-Jakob disease;Neurodegenerative disease;transmissible spongiform encephalopathy;prions;Prion protein; Mon, 16 Nov 2020 11:00:00 GMT Two technologies are better than one for understanding Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Two-technologies-for-understanding-Huntington-s-disease.aspx Researchers at MIRCen (CEA-Jacob) combined spectroscopy and metabolic imaging to identify novel biomarkers for Huntington's disease. Their approach enables the monitoring of disease course and may prove useful for exploring other neurodegenerative diseases or testing future treatments. Neurodegenerative diseases ; Genetic diseases ; MRI ; Cell and molecular imaging Researchers ; general public ; Journalists MIRcen Scientific result ; Highlight glutamate;gluCEST;huntington;NMR;neurodegenerative diseases; Fri, 31 Jul 2020 10:00:00 GMT Molecular chaperones and tauopathies: a double-edged sword https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Molecular- chaperones-tauopathies-double-edged-sword.aspx As part of an international study published in The Journal of Biological Chemistry, a team from LMN (MIRCen/CEA-Jacob) discovered an unexpected mechanism involving chaperone proteins in Tau disassembly. Neurodegenerative diseases ; Alzheimer's disease general public ; Journalists ; Researchers MIRcen Scientific result ; Highlight molecular chaperones;Alzheimer;tauopathies;neurodegenerative diseases; Fri, 17 Jul 2020 10:00:00 GMT Alzheimer's and Parkinson's diseases: infectious proteinopathies capture the attention of academicians https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/infectious-proteinopathies-capture-attention-of-academicians.aspx At a joint meeting of the French Academies of Medicine and Pharmacy held 19 November 2019, Ronald Melki of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob) gave a descriptive review of experimental elements enabling a better understanding of infectious proteinopathy in Alzheimer's and Parkinson's diseases. Alzheimer's disease ; Parkinson's disease ; Neurodegenerative diseases Journalists ; general public ; Researchers DRF News Alzheimer Disease;aggregation;abnormal Tau protein aggregates;Alzheimer;neurodegenerative diseases;Parkinson;tauopathies;Parkinson's disease; Sun, 05 Jul 2020 10:00:00 GMT Molecular "fingerprints" to better identify synucleinopathies https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/molecular-fingerprints-to-better-identify-synucleinopathies.aspx The term "synucleinopathy" covers a range of diseases, including Parkinson's disease, Lewy body dementia and multiple system atrophy, that involve pathological alpha-synuclein aggregations. An analysis of the properties of the different aggregate strains present in synucleinopathies has delineated the molecular bases of the diseases. The study, led by MIRCen (CEA-Jacob) researchers in partnership with the University of Louvain and Imperial College London, was published in Acta Neuropathologica Neurodegenerative diseases ; Parkinson's disease Researchers ; Journalists ; general public DRF Highlight ; Scientific result Neurodegenerative disease;dementia with Lewy bodies;multiple system atrophy;synuclein;synucleinopathies;Parkinson's disease; Thu, 30 Apr 2020 10:00:00 GMT Medical Research Foundation: 'mini-brains' to help Alzheimer's disease research https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Medical-Research-Foundation-mini-brains-to-help-Alzheimer-disease-research.aspx The FRM has just selected eight research projects in its call for projects on the fundamental mechanisms of Alzheimer's disease. A financial contribution of up to 600,000 euros has been allocated to fund the salaries, equipment and operating costs for each project for a period of 2 to 3 years. Among the funded projects, a project led by SEPIA (CEA-Jacob), Genoscope (CEA-Jacob) and ENS-Saclay, focuses on the use of cerebral organoids or 'mini-brains' as a model for the study of Alzheimer's disease. Alzheimer's disease ; Neurodegenerative diseases Researchers ; Journalists DRF Highlight ; News Alzheimer Disease;cerebral organoïds;neurodegenerative diseases; Mon, 30 Mar 2020 10:00:00 GMT Combining genetic engineering and stem cells to obtain tailormade "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Combining-genetic-engineering-and-stem-cells-to-obtain-tailormade-mini-brains.aspx Researchers from the SEPIA (CEA)-Sup'Biotech partnership laboratory and the Gly-CRRET (UPEC) laboratory have developed a genetic tool for the long-term expression of proteins in human brain organoids. This work, published in Frontiers in Cellular Neuroscience, concerns the modelling of a genetic form of frontotemporal dementia, a neurodegenerative disease with a tauopathic side similar to Alzheimer's disease. Stem cells ; Neurodegenerative diseases Researchers ; Journalists Jacob Highlight ; Scientific result ; News Alzheimer Disease;neurodegenerative diseases;gene expression;stem cell;episomal plasmid;cerebral organoids; Wed, 18 Mar 2020 11:00:00 GMT Alzheimer: an amino acid to the rescue of astrocyte metabolism https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Alzheimer-an-amino-acid-to-the-rescue-of-astrocyte-metabolism.aspx Scientists from the Laboratory of Neurodegenerative Diseases (MIRCen/ François Jacob Institute of Biology) in collaboration with the Neurocentre Magendie (Inserm/University of Bordeaux) have highlighted the decisive role played by a metabolic pathway in memory disorders in Alzheimer's disease. Their work, published in Cell Metabolism, also shows that L-serine intake, in the form of a dietary supplement, restores the spatial memory that is affected early on in mouse models of the disease. Neurodegenerative diseases ; Alzheimer's disease Researchers ; Journalists DRF Highlight ; Scientific result ; News Alzheimer;L-serine;astrocytes;Brain;neurodegenerative diseases; Tue, 03 Mar 2020 11:00:00 GMT Le Monde immersed in the world of "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Le-Monde-immersed-in-the-world-of-mini-brains.aspx On February 12th, a dossier on cerebral organoids was published in the Cahier Sciences et Médecine of the newspaper Le Monde: "Cerebroids: from mini-organs to maxi-powers ?" Report in the SEPIA/Sup'Biotech partnership laboratory. Neurodegenerative diseases ; Stem cells Researchers ; Journalists DRF Highlight Sun, 16 Feb 2020 11:00:00 GMT Synucleinopathies: the shape of diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Synucleinopathies-the-shape-of-diseases.aspx As part of an international partnership, a team from the Neurodegenerative Diseases Laboratory (MIRCen) has characterized the pathological effects of various alpha-synuclein aggregate strains in vivo. In their work, published in Acta Neuropathologica Communications, the researchers showed that the conformation of these aggregates plays a key role in their amplification and propagation in the brain. Neurodegenerative diseases ; Parkinson's disease Researchers ; Journalists DRF Highlight ; News ; Scientific result Brain;Parkinson's disease;Parkinson;synucleinopathies;neurodegenerative diseases; Mon, 03 Feb 2020 11:00:00 GMT Parkinson's disease: Journey to the Center of Alpha-Synuclein https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Parkinson-disease-journey-center-alpha-synuclein.aspx A new structure for aggregated alpha-synuclein has been determined at the atomic level using cryo-electron microscopy. The work, lead by a team from MIRCen's Neurodegenerative Diseases Laboratory, was published in the journal eLife. The determination of this previously undescribed structure opens new doors for the development of ligands specifically targeting alpha-synuclein aggregates in Parkinson's disease. Parkinson's disease Researchers ; Journalists Fontenay-aux-Roses Highlight ; News ; Scientific result alpha-synuclein;Parkinson's disease;cryo microscopy;Biochemistry;NMR; Tue, 10 Dec 2019 11:00:00 GMT NeurATRIS: "Translational Neuroscience Day " https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/Translational-Neuroscience-day.aspx NeurATRIS and Dhune are delighted to announce that the next edition of “Translational neuroscience Day: challenges and opportunities”, will be held on December 10, 2019, in Marseille and hosted by BioFit. Neurodegenerative diseases ; Brain Researchers Jacob Conference neurosciences; Wed, 16 Oct 2019 10:00:00 GMT New knowledge for cell therapies in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/New-knowledge-for-cell-therapies-in-neurodegenerative-diseases.aspx MIRCen contributed to a study that showed that the use of histocompatible neuronal grafts did not eliminate the need for immunosuppressive drugs in a primate model. Those results provide important knowledge for the clinical use of certain cell therapies under development for the treatment of neurodegenerative diseases. Brain ; Neurodegenerative diseases ; Gene and cell therapy Scientific result Wed, 09 Oct 2019 10:00:00 GMT Neurodegeneration may be induced by brains of Alzheimer patients https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Neurodegeneration-may-be-induced-by-brains-of-Alzheimer-patients.aspx MIRCen researchers have shown that the intracerebral injection of Alzheimer brain extracts into a primate induces lesions typical of the disease and neurodegenerative processes associated with memory loss. Brain ; Neurodegenerative diseases ; Alzheimer's disease Scientific result Mon, 16 Sep 2019 10:00:00 GMT Astrocytic mitochondria help you remember https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Astrocytic-mitochondria-memory.aspx With help from MIRCen, an international team has shown that the mitochondria of astrocytes (neuron support cells) intervene in the regulation of memory. Brain ; Neurodegenerative diseases ; Cellular mechanisms general public ; Researchers ; Journalists Paris-Saclay Scientific result neurons;mitochondria;astrocytes;memory;Brain;neurosciences; Thu, 28 Mar 2019 11:00:00 GMT Using NMR spectroscopy to detect cell morphology alterations in vivo https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Using-NMR-spectroscopy-detect-cell-morphology-alterations-in-vivo.aspx Julien Valette and his group at MIRCen have developed in vivo nuclear magnetic resonance spectroscopy techniques to quantify certain morphological characteristics of neurons and astrocytes. Health & life sciences ; Neurodegenerative diseases Researchers ; general public ; Journalists Paris-Saclay Highlight ; Scientific result NMR spectroscopy methods;neurons;astrocytes;Brain;Neurodegenerative disease; Wed, 06 Mar 2019 07:00:00 GMT Pairing 3D histology and voxel-based analysis: a new approach for studying neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Pairing-3D-histology-voxel-based-analysis-new-approach-studying-neurodegenerative-diseases.aspx An innovative method uniting 3D histological reconstructions and voxel-based analysis developed by a CEA/CNRS team at MIRCen enables the automated identification of cerebral zones were proteins characteristic of Alzheimer's disease develop. Neurodegenerative diseases ; Health & life sciences Researchers ; general public Paris-Saclay Scientific result histology;statistical analysis;voxel;Neurodegenerative disease;3d;Alzheimer; Fri, 22 Feb 2019 07:00:00 GMT "Mini-brains" for research on Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/mini-brains-research-Alzheimer-disease.aspx A partnership between the François Jacob Institute of Biology/CEA, The Frédéric Joliot Institute for Life Sciences/CEA and CellTechs (a Sup'Biotech lab) has led to a new approach for modeling Alzheimer's disease in vitro. Health & life sciences ; Brain ; Alzheimer's disease MIRcen Scientific result Brain;Alzheimer; Mon, 14 Jan 2019 11:00:00 GMT Alzheimer’s: identification of potential target protein aggregates for treating the disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/alzheimer-identification-potential-target-protein-aggregates-disease.aspx The propagation of tau protein aggregates in the brain contributes to the progression of Alzheimer’s disease. Researchers at the Neurodegenerative Diseases Laboratory: mechanisms, therapies, imaging (CNRS/CEA/Université Paris-Sud, MIRCen), working in collaboration with the Ecole Normale Supérieure, Sorbonne University and Inserm, have just identified the targets of these aggregates. Alzheimer's disease ; Brain ; Health & life sciences general public ; Institutions ; Journalists ; Researchers ; Higher education DRF Press release CNRS;inserm; Thu, 10 Jan 2019 11:00:00 GMT Alzheimer's disease: blocking reactive astrocytes to help neurons https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Alzheimer-disease-blocking-reactive-astrocytes-help-neurons.aspx Researchers from MIRCen have shown that inhibiting reactive astrocytes is beneficial for certain characteristics of Alzheimer's disease. Their results could lead to novel therapies that act upon astrocytes to improve neuron function. Brain ; Gene and cell therapy ; Alzheimer's disease ; Cellular mechanisms Paris-Saclay Scientific result Alzheimer;astrocytes;neuron; Mon, 29 Oct 2018 11:00:00 GMT Darwinian selection happens in test tubes too https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Darwinian-selection-in-test-tubes.aspx Bringing successive mutations to DNA and RNA in test tubes has been possible for several decades now. A MIRCen team has shown that high throughput sequencing can, with unequaled precision, reconstitute the evolutionary path taken by these macromolecules during their in vitro selection process, and furthermore that this path respects Darwinian theory. Methodologies for life sciences ; Diagnosis and innovative treatment ; Neurodegenerative diseases ; Evolution Fontenay-aux-Roses Scientific result in vitro selection;aptamers; Tue, 17 Jul 2018 10:00:00 GMT Huntington's disease and DCLK3: a vicious circle of gene transcription deregulation? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Huntington-DCLK3-vicious-circle-transcription-deregulation.aspx The results of a study performed by a research team at MIRCen suggest that the protein DCLK3 plays a key role in transcription regulation, and its deficit in Huntington's disease a key role in neurodegeneration. Neurodegenerative diseases ; Cellular mechanisms ; Molecular mechanisms Fontenay-aux-Roses Scientific result chromatin remodeling;transcription;DCLK3; Mon, 26 Mar 2018 10:00:00 GMT A summertime reduction in the plasma level of a peptide association with Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/summertime-reduction-plasmatic-amyloid-alzheimer.aspx Researchers from MIRCen have brought to light a reduction in the amount of an amyloid beta peptide associated with Alzheimer's disease in the plasma of a primate model during the summer season. Alzheimer's disease Fontenay-aux-Roses Scientific result Amyloid; Fri, 23 Mar 2018 11:00:00 GMT Neurofibrillary tangles: a protective role in Alzheimer's disease? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/neurofibrillary-tangles-protective-role-alzheimer.aspx Neurofibrillary tangles are large aggregates of tau protein found in the neurons of people with Alzheimer's disease. Historically, they have been thought to be at least partially responsible for the pathology. However, the results of a study performed by researchers at MIRCen (François Jacob Institute of Biology/CEA) suggest to the contrary that neurofibrillary tangles may be protective. Alzheimer's disease ; Molecular mechanisms Fontenay-aux-Roses Scientific result neurofibrillary tangles;tau protein;hyperphosphorylation; Thu, 08 Mar 2018 11:00:00 GMT NeurATRIS : Call for collaborative projects on neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2018/Neuratris-call.aspx ​NeurATRIS lance un appel à projets pour initier des projets collaboratifs entre les membres de NeurATRIS, les laboratoires académiques et les sociétés de biotechnologies. A la clé, un financement à hauteur de 50K€. Diagnosis and innovative treatment ; Gene and cell therapy ; Neurodegenerative diseases News ; Academic partnerships ; Industrial partnerships Thu, 18 Jan 2018 11:00:00 GMT A researcher from the Institut François Jacob awarded the CNRS 2017 bronze medal https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2017/Une-chercheuse-de-institut-francois-jacob-medaille-de-bronze-CNRS-2017.aspx Carole Escartin, a researcher at the François Jacob Institute of Biology (IBFJ), has won the CNRS 2017 bronze medal. This medal rewards the first work of a researcher and represents an encouragement from the CNRS to pursue research that has already been productive. Neurodegenerative diseases ; Cellular mechanisms MIRcen Prizes and awards Fri, 24 Nov 2017 11:00:00 GMT Alzheimer's disease: a novel animal model https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Alzheimer-novel-animal-model.aspx A new animal model expresses the two biological characteristics of Alzheimer's disease, enabling new possibilities for treatment assessment and simplified diagnosis. Simulation & modelling ; Alzheimer's disease Researchers ; general public ; Journalists Fontenay-aux-Roses Scientific result Fri, 20 Oct 2017 10:00:00 GMT Modulating cerebral cholesterol: a new avenue of research to treat Alzheimer’s disease? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2015/Modulating-cerebral-cholesterol-new-avenue-research-treat-Alzheimer.aspx Two French research teams have recently shown in a rodent model that overexpression of an enzyme capable of eliminating excess cholesterol in the brain can act in a beneficial way on the tau component of the disease to completely correct it. Alzheimer's disease ; Gene and cell therapy ; Biotechnology MIRcen Scientific result Mon, 14 Sep 2015 10:00:00 GMT