François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Alzheimer-disease-blocking-reactive-astrocytes-help-neurons.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english Rad51-mediated homologous recombination: insights into aging and tumorigenesis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/rad-medited-homologous-recombination-aging-tumorigenesis.aspx Using a murine preclinical model wherein Rad51 was selectively inhibited, researchers from the Laboratory of Development of the Gonads (iRCM:CEA-Jacob) and the Institut Cochin showed that in vivo alteration of Rad51-mediated homologous recombination does not favor the development of cancers, it reduces it. The team's work was published in The Embo Journal. Cellular mechanisms ; Stress response ; DNA Researchers ; Journalists IRCM Scientific result ; Highlight DNA;homologous recombination;premature aging; Wed, 18 Oct 2023 10:00:00 GMT The nuclear pore: a safe place for gene expression https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/nuclear-pore-safe-place-gene-expression.aspx In an article published in Nature Communications, researchers from Institut Jacques-Monod and iRCM (CEA-Jacob) merged imaging and biochemistry approaches to show that the genes involved in expression are conducted to nuclear pores in order to protect the genome. DNA ; Cellular mechanisms ; Molecular mechanisms Researchers ; Journalists IRCM Highlight ; Scientific result R-loop;RNA;gene;nuclear; Tue, 03 Oct 2023 10:00:00 GMT When a sporadic event changes the course of Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/sporadic-event-changes-course-Alzheimer-disease.aspx In a new study performed in a mouse model and published in Acta Neuropathologica Communications, researchers from the LMN (MIRCen/CEA-Jacob) have shown that the experimental transmission of abnormal amyloid-β proteins accelerates, over time, the development of cerebral lesions and memory disorders. Brain ; Neurodegenerative diseases Researchers ; Journalists DRF Scientific result ; Highlight Brain;preclinical studies;Alzheimer's Disease;amyloid deposits; Mon, 03 Jul 2023 10:00:00 GMT An Alzheimer's model to study the propagation of the pathological forms of tau https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/Alzheimer-propagation-forms-pathological-Tau-.aspx In an article published in Neurobiology of Disease, researchers from MIRCen's Neurodegenerative Diseases Laboratory present a novel model of Alzheimer's disease that enables the study of tauopathy inter-neuronal propagation mechanisms, the identification of new therapeutic targets and the exploration of new treatments. Neurodegenerative diseases ; Alzheimer's disease ; Cellular mechanisms Researchers ; general public ; Journalists MIRcen Highlight ; Scientific result Alzheimer Disease;Cellular biology;tau protein;AAV; Fri, 16 Jun 2023 10:00:00 GMT XLF/Cernunnos: premature neurogenesis and delayed brain development https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/xlf-cernunnos-premature-neurogenesis-brain-development.aspx In a work published in Cell Reports, researchers from the SGCSR mixed research unit (IRCM) have shown that the loss of XLF (a.k.a. Cernunnos), a component of the non-homologous end-joining complex, severely alters brain development and function in mice. Cellular mechanisms ; Stem cells ; Stress response ; Brain ; Cell division Researchers ; general public ; Journalists IRCM Highlight ; Scientific result neural progenitor cells;DNA repair;genome stability;mitosis;NHEJ;neurogenesis;microcephaly;brain development; Fri, 21 Apr 2023 10:00:00 GMT LMN/MIRCen team wins "Équipe FRM 2023" accreditation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2023/lmn-mircen-frm-team.aspx Carole Escartin's Reactive Astrocytes team (UMR9199, Neurodegenerative Diseases Laboratory, MIRCen) has received the Équipe FRM 2023 label for its project on the role of astrocytes in the control of neuronal activity. Institutional ; Fundamental Research ; Brain ; Diagnosis and innovative treatment ; Gene and cell therapy ; Alzheimer's disease Researchers ; Journalists ; general public DRF Live in the center ; Highlight astrocytes;Alzheimer's Disease; Wed, 29 Mar 2023 10:00:00 GMT A model to better understand oogenesis and female infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/model-oogenesis-femaile-infertility.aspx In a work published in Cells, researchers from LDG (IRCM) used human induced pluripotent stem cells to develop an in vitro model capable of reproducing the early stages of oogenesis. Cellular mechanisms ; Stem cells ; Cell division Researchers ; Journalists ; general public SCSR Highlight ; Scientific result induced pluripotent stem cells;oogenesis;infertility;primordial germ cells;podoplanin;model; Thu, 16 Mar 2023 11:00:00 GMT MXD4/MAD4 : a target of interest for ex vivo stem cell preservation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/MXD4-MAD4-stel-cell-preservation.aspx In a study published in the Journal of Investigative Dermatology, researchers from LGRK (iRCM) identified the transcription factor MXD4/MAD4 as an element of the pathway regulating the stemness of keratinocyte precursors and their skin regeneration capacities. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public DRF Scientific result ; Highlight MXD4/MAD4;bioengineering;skin;skin repair;graft;stemness;cutaneous; Fri, 03 Feb 2023 11:00:00 GMT Retinoic acid receptors and neuronal differentiation: white-hat hijacking https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/retinoic-acid-receptors-neuronal-differentiation.aspx In a study published in Life Science Alliance, Genoscope researchers paired cell engineering and transcriptomics to explore gene regulatory programs driven by retinoic acid receptors and what role they play in neuronal differentiation. Brain ; Transcriptomics Researchers ; Journalists DRF Scientific result ; Highlight neuronal differentiation;retinoic acid receptor;gene regulatory programs;stemcelles;Brain; Tue, 20 Dec 2022 11:00:00 GMT An in vitro model to study infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/in-vitro-model-study-infertility.aspx In a work published in Scientific Reports, researchers from IRCM, the Sup'Biotech/SEPIA partnership lab and Imagine Institute teamed to develop an in vitro, model of infertility wherein induced pluripotent stem cells generated from the erythroblasts of infertile men presenting genetic abnormalities were used to successfully generate primordial germ-like cells. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public IRCM Highlight ; Scientific result stem cells;infertility;azoospermia; Mon, 28 Nov 2022 11:00:00 GMT IDMIT partner of the European consortium INDENEO in the framework of the Rare Disease Research Challenge Call https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/IDMIT-consortium-INDENEO-rare-disease.aspx Following the Rare Disease Research Challenge Call launched by the European Joint Programme for Rare Disease and the Rare Disease Foundation, the European INDENEO consortium project has been selected to respond to the challenge targeting the development of a system for intranasal administration of biological drugs to newborns. Among the partners of this project, IDMIT brings its expertise in preclinical trials. Brain Researchers ; Journalists ; general public Jacob Live in the center ; Highlight Brain;preclinical research;neonatology; Wed, 13 Jul 2022 10:00:00 GMT Does the menstrual cycle affect the risk of STIs? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/menstrual-cycle-risk-STI.aspx Researchers from IDMIT describe the course of immune & inflammatory markers and the vaginal microbiome during the menstrual cycle. Infectious diseases ; Cellular mechanisms ; Immune system Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight bacteria;HIV;HIV-AIDS;Infectious Disease;immune response;cellular immune responses;viruses;therapy; Fri, 20 May 2022 10:00:00 GMT ComFC, a key protein in the transmission of antibiotic resistance among bacteria https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/ComFC-transmission-antibiotic-resistance-bacteria.aspx A team of researchers from IRCM (CEA-Jacob) and I2BC have shed light on the role of ComFC, a bacterial protein involved in natural transformation, itself a driving mechanism for the propagation of antibiotic resistance genes and virulence factors. Cellular mechanisms ; Molecular mechanisms ; Antibiotics Researchers ; general public ; Journalists SCSR Highlight ; Scientific result bacteria;Antibiotic;Antibiotic Resistance;Molecular mechanisms; Tue, 19 Apr 2022 10:00:00 GMT Do other primates daydream like we do? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/primates-daydream.aspx In an article published in Cell Reports, an international team including researchers from MIRCen showed that a cerebral network associated with highly elaborate cognitive capacities in humans differs from the comparable network in non-human primates. Brain ; Cognition Researchers ; Journalists ; general public DRF Scientific result ; Highlight Evolution;Brain;Primate;cognition;MRI;IRM;Imaging; Wed, 13 Apr 2022 10:00:00 GMT Inflammation and COVID-19: the HLA-G immune checkpoint under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/inflammation-Covid-19-HLA-G-checkpoint-immune-surveillance.aspx In a study published in Viruses, a team of researchers from SRHI and the University of Ferrara (Italy) showed that the soluble form of HLA-G may contribute significant anti-inflammatory properties via its role in controlling the adhesion of neutrophils to endothelial cells and thus improve disease outcome in patients with COVID-19. Infectious diseases ; Cellular mechanisms Researchers ; Journalists ; general public SRHI Scientific result ; Highlight HLA-G;COVID-19;endothelial cells;Angiogenesis;neutrophil; Tue, 11 Jan 2022 11:00:00 GMT The metabolic cooperation of astrocytes and neurons fashions brain activity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/metabolic-cooperation-astrocytes-neurons-brain-activity.aspx In a review published in Cell Metabolism, Gilles Bonvento (LMN/MIRCen/CEA-Jacob) and Juan P. Bolaños (IBFG/University of Salamanca) present the latest findings on astrocyte-neuron metabolic cooperation and how it affects brain function. Brain Researchers ; Journalists ; general public DRF Scientific result ; Highlight Brain;metabolism;astrocyte;neurons; Tue, 03 Aug 2021 10:00:00 GMT Diffusion MRI characterizes radiation-induced neurological impairments https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/diffusion-MRI-characterizes-radiation-induced-neurological-impairments.aspx A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress. Brain ; Impacts on living (organisms) ; MRI ; Biomarkers ; Radiobiology Researchers ; Journalists ; general public DRF Scientific result ; Highlight ionizing radiations;Brain;neurodevelopmental disorder;neurogenesis;MRI;structural MRI;diffusion MRI; Thu, 24 Jun 2021 10:00:00 GMT Beta thalassemia: toward a more effective therapeutic strategy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/beta-thalassemia-more-effective-therapeutic-strategy.aspx In a study published in Molecular Therapy, LCSAT (IDMIT, CEA-Jacob) researchers present a novel, optimized, lentiviral gene therapy for β-thalassemia. Gene and cell therapy Researchers ; general public ; Journalists STI Scientific result ; Highlight lentiglobin;lentiviral gene therapy;beta-thalassemia;he; Thu, 20 May 2021 10:00:00 GMT "Fingerprints" to differentiate pathogenic alpha-synuclein aggregates https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/fingerprints-pathogenic-alpha-synuclein-aggregates.aspx In a study published in JBC, researchers from MIRCen (CEA-Jacob) deployed a range of techniques to map the surfaces of various pathogenic alpha-synuclein aggregates, establishing thus "fingerprints" specific to each aggregate. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; Journalists ; general public DRF Scientific result ; Highlight therapeutic targets;diagnosis;Parkinson;Parkinson's disease;Fingerprint;alpha-synuclein;Lewy body dementia; Wed, 12 May 2021 10:00:00 GMT Tau's wanderlust in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/tau-neurodegenerative-diseases.aspx In an unprecedented work published in Brain, researchers from LMN (MIRCen/CEA-Jacob) showed that these abnormal tau proteins migrate from neurons to astrocytes, another type of cell within the brain, and remain toxic in the astrocytes as well. Neurodegenerative diseases ; Brain Researchers ; Journalists ; general public DRF Scientific result ; Highlight tau;astrocytes;Neurodegenerative disease;tauopathies;neuron; Mon, 12 Apr 2021 10:00:00 GMT Targeting HIF1α or JMY in glioblastoma: if not one why not the other? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HIF1-JMY-glioblastoma-targeting.aspx Glioblastomas are highly aggressive brain tumors with a very poor prognosis. Even with aggressive treatment, recurrence is nearly systematic. Researchers from IRCM (CEA-Jacob) have decrypted molecular mechanisms that enable treatment resistance and escape for a subpopulation of cells. Brain ; Cancer ; Stem cells Researchers ; Journalists ; general public SCSR Highlight ; Scientific result Brain;glioblastoma;Cancer;invasion;Tumor;ionizing radiations;HIF1α; Thu, 01 Apr 2021 10:00:00 GMT Astrocytes and α-synuclein in Parkinson's disease: when size matters https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/astrocytes-alpha-synuclein-Parkinson-size-matters.aspx Researchers from MIRCen (CEA-Jacob) have shown that exposure to alpha-synuclein aggregates may affect dopaminergic neuron survival in Parkinson's disease by reducing astrocyte support for them. Parkinson's disease ; Neurodegenerative diseases ; Brain Researchers ; Journalists ; general public Jacob Scientific result ; Highlight stem cells;Parkinson's disease;astrocytes;alpha-synuclein;aggregates;neuroinflammation; Mon, 29 Mar 2021 10:00:00 GMT Alpha-synuclein in Parkinson's disease : a versatile protein https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/alpha-synuclein-Parkinson-versatile-protein.aspx In an international collaboration, a team from MIRCen (CEA-Jacob) studied the properties of toxic alpha-synuclein aggregates in fixed brain samples from patients, depending on their tissue origin and the type of synucleinopathy developed. Brain ; Parkinson's disease ; Neurodegenerative diseases Researchers ; general public ; Journalists DRF Scientific result ; Highlight Parkinson's disease;proteolysis;enteric nervous system;Brain;alpha-synuclein;PMCA;transmission electron microscopy;protein misfolding; Thu, 18 Mar 2021 11:00:00 GMT Lucile Ben Haïm wins support from Vaincre Alzheimer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/Lucile-Ben-Haim-wins-support-from-Vaincre-Alzheimer.aspx Every year, the foundation Vaincre Alzheimer lends its support to promising projects in the battle against Alzheimer's disease. Among the six chosen this year is that of Lucile Ben Haïm of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob). Her project involves targeting astrocytes to treat depression symptoms associated with this progressive neurological disorder. Alzheimer's disease Researchers ; Journalists ; general public Live in the center astrocyte;Alzheimer;Depression;reactive astrocytes; Wed, 17 Feb 2021 11:00:00 GMT Finally, a bit of agreement on reactive astrocytes ! https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/bit-of-agreement-reactive-astrocytes.aspx In an article entitled "Reactive astrocyte nomenclature, definitions, and future directions," published as a first consensus statement in the journal Nature Neuroscience, more than 80 international specialists, including Carole Escartin from LMN (MIRCen/CEA-Jacob) as first co-author, have established a nomenclature and definitions for reactive astrocytes. Brain ; Neurodegenerative diseases Researchers ; general public ; Journalists Highlight ; Scientific result neurons;Brain;neurodegenerative diseases;consensus;astrocytes;reactive astrocytes;Biomarkers; Mon, 15 Feb 2021 11:00:00 GMT The journal L'Édition of Université Paris-Saclay shines a light on stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/stem-cells-Edition-Universite-Paris-Saclay.aspx Read about the contributions of two François Jacob Institute of Biology laboratories in an article on human stem cells and their use in research published in the most recent edition of the journal L'Édition of Université Paris-Saclay. The article discusses the interest of stem cells for the development of novel disease models and potential therapies. Stem cells Researchers ; Journalists ; general public IRCM Live in the center stem cells; Sun, 14 Feb 2021 11:00:00 GMT PET Imaging to visualize neuroinflammation in patients with Parkinson's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/PET-imaging-visualize-neuroinflammation-patients-Parkinson-disease.aspx Researchers from MIRCen (CEA-Jacob) teamed with the Frédéric Joliot Medical Imaging Center (SHFJ; CEA-Joliot) and the Henri-Mondor and Saint-Anne Hospitals to analyze neuroinflammatory response in a cohort of patients with Parkinson's disease and reported a correlation between it and disease progression. Their study, published in Parkinsonism & Related Disorders, sets a path toward the use of a radiotracer, [¹⁸F]-DPA714, for the evaluation of anti-inflammatories pertinent to the treatment of Parkinson's disease. Parkinson's disease ; Medical imaging ; MRI ; Positron Emission Tomography ; Brain Journalists ; Researchers ; general public DRF Scientific result TSPO;brain imaging;radiotracer;neuroinflammatory processes;neuroinflammation;dopamine;Neurodegenerative disease;PET imaging;Parkinson's disease; Fri, 18 Dec 2020 11:00:00 GMT Brain function in the world's smallest primate—in 3D https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Brain-function-world-smallest-primate-3D.aspx In an article published in NeuroImage, a CEA/CNRS/Paris-Saclay University team from MIRCen (CEA-Jacob) has described neuronal networks in the mouse lemur (Microcebus murinus), one of the smallest primates and one of the most genetically-distant from humans. Brain ; Cognition ; MRI ; Medical imaging Researchers ; Journalists MIRcen Scientific result ; Highlight high field MRI;in vivo imaging;3D imaging;Brain;functional MRI;MRI;brain imaging; Wed, 16 Dec 2020 11:00:00 GMT Stealthy agents in Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Stealthy-agents-Alzheimer-disease.aspx Researchers from MIRCen (CEA-Jacob) have shown that undetectable proteinaceous aggregates involved in Alzheimer's disease can be transmitted during brain surgeries in an experimental context. Brain ; Neurodegenerative diseases ; Alzheimer's disease Researchers ; general public ; Journalists MIRcen Scientific result ; Highlight amyloid deposits;Alzheimer Disease;transmission;neurodegenerative diseases; Wed, 09 Dec 2020 11:00:00 GMT New mode of propagation identified for variant Creutzfeldt-Jakob disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/new-mode-propagation-variant-Creutzfeldt-Jakob.aspx In an article published in Acta Neuropathologica, researchers from SEPIA (CEA-Jacob) reported the discovery of a new mode of prion propagation from a localized contamination. Neurodegenerative diseases ; Brain ; Prion diseases Researchers ; Journalists SEPIA News ; Highlight ; Scientific result Creutzfeldt-Jakob;prion diseases;Creutzfeldt-Jakob disease;Neurodegenerative disease;transmissible spongiform encephalopathy;prions;Prion protein; Mon, 16 Nov 2020 11:00:00 GMT Skin and ionizing radiation: sensitivity under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/skin-ionizing-radiation-sensitivity-under-surveillance.aspx In a study published in Cells, researchers from LGRK (IRCM/CEA-Jacob) showed that human skin stem cells are sensitive to low doses of genotoxic stress in the setting of active regeneration. Stem cells ; Radiobiology ; Radiosensitivity ; Radiotherapy Researchers ; Journalists DRF Scientific result ; Highlight epidermis;skin;organoids;ionizing radiation;keratinocyte stem cells;medical imaging;radiosensitivity; Wed, 07 Oct 2020 10:00:00 GMT The brain: a careful balance between stability and genetic variability https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/The-brain-balance-stability-variability.aspx In a study published in DNA Repair, an IRCM (CEA-Jacob) team has elucidated mechanisms through which neural stem and progenitor cells maintain genome integrity more efficaciously than other cell types. The team's work contributes to a better understanding of the high-fidelity transmission of genetic information so crucial to brain development. Brain ; DNA ; Stem cells ; Stress response Researchers ; general public ; Journalists DRF Scientific result ; Highlight adaptive response;chromosome stability;genetic diversity;neural progenitor cells;Brain;DNA repair;development;radiation;genotoxic stress;non-homologous end-joining;Neural stem cells; Mon, 20 Jul 2020 10:00:00 GMT Molecular chaperones and tauopathies: a double-edged sword https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Molecular- chaperones-tauopathies-double-edged-sword.aspx As part of an international study published in The Journal of Biological Chemistry, a team from LMN (MIRCen/CEA-Jacob) discovered an unexpected mechanism involving chaperone proteins in Tau disassembly. Neurodegenerative diseases ; Alzheimer's disease general public ; Journalists ; Researchers MIRcen Scientific result ; Highlight molecular chaperones;Alzheimer;tauopathies;neurodegenerative diseases; Fri, 17 Jul 2020 10:00:00 GMT Alzheimer's and Parkinson's diseases: infectious proteinopathies capture the attention of academicians https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/infectious-proteinopathies-capture-attention-of-academicians.aspx At a joint meeting of the French Academies of Medicine and Pharmacy held 19 November 2019, Ronald Melki of the Neurodegenerative Diseases Laboratory (MIRCen/CEA-Jacob) gave a descriptive review of experimental elements enabling a better understanding of infectious proteinopathy in Alzheimer's and Parkinson's diseases. Alzheimer's disease ; Parkinson's disease ; Neurodegenerative diseases Journalists ; general public ; Researchers DRF News Alzheimer Disease;aggregation;abnormal Tau protein aggregates;Alzheimer;neurodegenerative diseases;Parkinson;tauopathies;Parkinson's disease; Sun, 05 Jul 2020 10:00:00 GMT Federating research organisms to extend the reach of preclinical imaging research https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/federating-research-organisms-to-extend-the-reach-of-preclinical-imaging-research.aspx A study on preclinical imaging involving several national research organisms (Inserm, CNRS, CEA, Universities) has produced MRI relaxometry maps for healthy rat brains. The impetus for that work is to be found in the France Life Imaging (FLI) initiative and its continuing momentum manifests today as the Small Animal Imaging Network (SAIN), which unites about ten French imaging facilities. The study, published in Frontiers in Neuroinformatics, demonstrates the feasibility of large-scale, multicenter, MRI studies in the preclinical setting. Brain ; MRI Journalists ; Researchers ; general public DRF Scientific result preclinic;relaxometry;brain imaging;mapping;MRI;in vivo imaging;Brain;neurosciences; Mon, 22 Jun 2020 10:00:00 GMT Medical Research Foundation: 'mini-brains' to help Alzheimer's disease research https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Medical-Research-Foundation-mini-brains-to-help-Alzheimer-disease-research.aspx The FRM has just selected eight research projects in its call for projects on the fundamental mechanisms of Alzheimer's disease. A financial contribution of up to 600,000 euros has been allocated to fund the salaries, equipment and operating costs for each project for a period of 2 to 3 years. Among the funded projects, a project led by SEPIA (CEA-Jacob), Genoscope (CEA-Jacob) and ENS-Saclay, focuses on the use of cerebral organoids or 'mini-brains' as a model for the study of Alzheimer's disease. Alzheimer's disease ; Neurodegenerative diseases Researchers ; Journalists DRF Highlight ; News Alzheimer Disease;cerebral organoïds;neurodegenerative diseases; Mon, 30 Mar 2020 10:00:00 GMT Combining genetic engineering and stem cells to obtain tailormade "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Combining-genetic-engineering-and-stem-cells-to-obtain-tailormade-mini-brains.aspx Researchers from the SEPIA (CEA)-Sup'Biotech partnership laboratory and the Gly-CRRET (UPEC) laboratory have developed a genetic tool for the long-term expression of proteins in human brain organoids. This work, published in Frontiers in Cellular Neuroscience, concerns the modelling of a genetic form of frontotemporal dementia, a neurodegenerative disease with a tauopathic side similar to Alzheimer's disease. Stem cells ; Neurodegenerative diseases Researchers ; Journalists Jacob Highlight ; Scientific result ; News Alzheimer Disease;neurodegenerative diseases;gene expression;stem cell;episomal plasmid;cerebral organoids; Wed, 18 Mar 2020 11:00:00 GMT Alzheimer: an amino acid to the rescue of astrocyte metabolism https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Alzheimer-an-amino-acid-to-the-rescue-of-astrocyte-metabolism.aspx Scientists from the Laboratory of Neurodegenerative Diseases (MIRCen/ François Jacob Institute of Biology) in collaboration with the Neurocentre Magendie (Inserm/University of Bordeaux) have highlighted the decisive role played by a metabolic pathway in memory disorders in Alzheimer's disease. Their work, published in Cell Metabolism, also shows that L-serine intake, in the form of a dietary supplement, restores the spatial memory that is affected early on in mouse models of the disease. Neurodegenerative diseases ; Alzheimer's disease Researchers ; Journalists DRF Highlight ; Scientific result ; News Alzheimer;L-serine;astrocytes;Brain;neurodegenerative diseases; Tue, 03 Mar 2020 11:00:00 GMT Le Monde immersed in the world of "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Le-Monde-immersed-in-the-world-of-mini-brains.aspx On February 12th, a dossier on cerebral organoids was published in the Cahier Sciences et Médecine of the newspaper Le Monde: "Cerebroids: from mini-organs to maxi-powers ?" Report in the SEPIA/Sup'Biotech partnership laboratory. Neurodegenerative diseases ; Stem cells Researchers ; Journalists DRF Highlight Sun, 16 Feb 2020 11:00:00 GMT A bit of air please... https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-bit-of-air-please-.aspx ...or how small amounts of oxygen contribute to the preservation of lymphocyte progenitors in humans. In an article published in Cell Reports, researchers from LSHL (IRCM) shared new findings on the role of hypoxia in human lymphocyte differentiation. Stem cells ; Immune system Researchers ; Journalists Jacob News ; Highlight ; Scientific result hematopoietic differentiation;T lymphocytes;Hematopoietic stem cells;hypoxia;Immune system; Tue, 19 Nov 2019 11:00:00 GMT Using color to track astrocytes in high resolution https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Using-color-track-astrocytes-high-resolution.aspx Researchers from MIRCen partnered with École Polytechnique, the CNRS, Inserm and LOB to develop combinatorial labeling techniques wherein color and 3D and high-resolution imaging are used to demonstrate astrocyte plasticity during cerebral cortex development. Brain Researchers ; Journalists Jacob Scientific result ; News ; Highlight cortex;stem cell;astrocytes;Brain;neural networks;plasticity;Neural stem cells; Fri, 08 Nov 2019 11:00:00 GMT Skin graft: a new molecular target for activating stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/Skin-graft-a-new-molecular-target-for-activating-stem-cells.aspx Fundamental Research ; Health & life sciences ; Cellular mechanisms ; Stem cells ; Genomics Press release ; Highlight ; Article ; Scientific result ; Success ; Focus Wed, 23 Oct 2019 10:00:00 GMT Skin grafts: KLF4, a new target for activating skin stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Skin-grafts-KLF4-new-target-for-activating-skin-stem-cells.aspx In a study published in Nature Biomedical Engineering, a team from the Genomics and Radiobiology of Keratinopoiesis laboratory (LGRK/ IRCM) has shown that a transcription factor, KLF4, plays a key role in the proliferation of the stem cells in the epidermis. The discovery brings new therapeutic perspectives to regenerative medicine. Stem cells Researchers ; Journalists Jacob Scientific result ; Highlight ; News skin;keranocytes;stem cell;graft;cell therapy;keratinocyte stem cells; Tue, 22 Oct 2019 10:00:00 GMT NeurATRIS: "Translational Neuroscience Day " https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2019/Translational-Neuroscience-day.aspx NeurATRIS and Dhune are delighted to announce that the next edition of “Translational neuroscience Day: challenges and opportunities”, will be held on December 10, 2019, in Marseille and hosted by BioFit. Neurodegenerative diseases ; Brain Researchers Jacob Conference neurosciences; Wed, 16 Oct 2019 10:00:00 GMT New knowledge for cell therapies in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/New-knowledge-for-cell-therapies-in-neurodegenerative-diseases.aspx MIRCen contributed to a study that showed that the use of histocompatible neuronal grafts did not eliminate the need for immunosuppressive drugs in a primate model. Those results provide important knowledge for the clinical use of certain cell therapies under development for the treatment of neurodegenerative diseases. Brain ; Neurodegenerative diseases ; Gene and cell therapy Scientific result Wed, 09 Oct 2019 10:00:00 GMT Neurodegeneration may be induced by brains of Alzheimer patients https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Neurodegeneration-may-be-induced-by-brains-of-Alzheimer-patients.aspx MIRCen researchers have shown that the intracerebral injection of Alzheimer brain extracts into a primate induces lesions typical of the disease and neurodegenerative processes associated with memory loss. Brain ; Neurodegenerative diseases ; Alzheimer's disease Scientific result Mon, 16 Sep 2019 10:00:00 GMT The genome of the pea assembled for the first time https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/The-genome-of-the-pea-assembled-for-the-first-time.aspx Fundamental Research ; Science & society ; Health & life sciences ; Methodologies for life sciences ; Molecular mechanisms ; Cellular mechanisms ; Genomics Press release ; News ; Focus Tue, 03 Sep 2019 10:00:00 GMT Three-dimensional histology for PET quantification of brain imaging https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Three-dimensional-histology-for-PET-quantification-of-brain-imaging0830-8788.aspx With 3D histology, researchers from MIRCen highlighted, among nine methods of neuroinflammation PET quantification methods, the optimal performances of one of them. Brain ; Health & life sciences ; Positron Emission Tomography Highlight ; Scientific publications ; Scientific result Fri, 30 Aug 2019 10:00:00 GMT A new generation of lentivirus for gene therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-new-generation-of-lentivirus-for-gene-therapy.aspx Researchers from STI have developed a new generation of lentivirus, paving the way for the use of Mauritian cynomolgus macaque as a pre-clinical study model for the development of new gene therapy products. Health & life sciences ; Gene and cell therapy Researchers ; Journalists STI Highlight ; Scientific result DNA;Gene and cell therapy;pre-clinical; Mon, 22 Jul 2019 10:00:00 GMT The brain: a key participant in the development of cancer? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/The-brain-a-key-participant-in-the-development-of-cancer.aspx A French team from IRCM (CEA/Inserm) recently published a study in the scientific journal Nature showing that neurons can develop within the tumoral microenvironment and thus contribute to the development of certain types of cancer. Brain ; Cancer ; Health & life sciences ; Cellular mechanisms Researchers ; Journalists ; general public Paris-Saclay Scientific publications ; Scientific result ; News health;Cancer;neural network;Brain;neuron;neurosciences; Fri, 17 May 2019 10:00:00 GMT The Arctic Ocean: a "hot spot" of viral diversity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/The-Arctic-Ocean-a-hot-spot-of-viral-diversity.aspx A study on data collected largely by the Tara Oceans expedition has provided the most complete catalog to date of the viruses present in the world's oceans —and earned a place on the front page of the scientific journal Cell. The results reveal the key role of the Arctic Ocean as a reservoir for marine viruses. Climate ; Fundamental Research ; Oceanography ; Climatic models ; Virtual reality, augmented reality ; Cellular mechanisms Researchers ; Journalists ; general public Paris-Saclay News ; Scientific publications ; Scientific result sequencing;Tara Oceans;plankton;expedition;genomic sequencing;Climat;Arctique;virus; Thu, 25 Apr 2019 10:00:00 GMT Astrocytic mitochondria help you remember https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Astrocytic-mitochondria-memory.aspx With help from MIRCen, an international team has shown that the mitochondria of astrocytes (neuron support cells) intervene in the regulation of memory. Brain ; Neurodegenerative diseases ; Cellular mechanisms general public ; Researchers ; Journalists Paris-Saclay Scientific result neurons;mitochondria;astrocytes;memory;Brain;neurosciences; Thu, 28 Mar 2019 11:00:00 GMT THERANEXUS set to receive €6.2 million in funding from the French Investments for the Future program https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/THERANEXUS-set-to-receive-€6-2-million-in-funding-from-the-French-Investments-.aspx Health & life sciences ; Brain Jacob Press release ; Focus Wed, 30 Jan 2019 11:00:00 GMT "Mini-brains" for research on Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/mini-brains-research-Alzheimer-disease.aspx A partnership between the François Jacob Institute of Biology/CEA, The Frédéric Joliot Institute for Life Sciences/CEA and CellTechs (a Sup'Biotech lab) has led to a new approach for modeling Alzheimer's disease in vitro. Health & life sciences ; Brain ; Alzheimer's disease MIRcen Scientific result Brain;Alzheimer; Mon, 14 Jan 2019 11:00:00 GMT Alzheimer’s: identification of potential target protein aggregates for treating the disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/alzheimer-identification-potential-target-protein-aggregates-disease.aspx The propagation of tau protein aggregates in the brain contributes to the progression of Alzheimer’s disease. Researchers at the Neurodegenerative Diseases Laboratory: mechanisms, therapies, imaging (CNRS/CEA/Université Paris-Sud, MIRCen), working in collaboration with the Ecole Normale Supérieure, Sorbonne University and Inserm, have just identified the targets of these aggregates. Alzheimer's disease ; Brain ; Health & life sciences general public ; Institutions ; Journalists ; Researchers ; Higher education DRF Press release CNRS;inserm; Thu, 10 Jan 2019 11:00:00 GMT Alzheimer's disease: blocking reactive astrocytes to help neurons https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Alzheimer-disease-blocking-reactive-astrocytes-help-neurons.aspx Researchers from MIRCen have shown that inhibiting reactive astrocytes is beneficial for certain characteristics of Alzheimer's disease. Their results could lead to novel therapies that act upon astrocytes to improve neuron function. Brain ; Gene and cell therapy ; Alzheimer's disease ; Cellular mechanisms Paris-Saclay Scientific result Alzheimer;astrocytes;neuron; Mon, 29 Oct 2018 11:00:00 GMT New function discovered for the protein Rad52, a serious therapeutic target in breast cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Rad52 has garnered great attention lately as a promising target in the battle against certain types of breast cancer. A team from IRCM, in partnership with researchers from the Frédéric-Joliot and Gustave Roussy Institutes, has shed new light on this protein. Stress response ; Molecular mechanisms Jacob Scientific result Rad51 filament;budding yeast;Srs2; Fri, 12 Oct 2018 10:00:00 GMT Can eating less extend life? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/eating-less-extend-life.aspx The François Jacob Institute of Biology participated in a study showing that caloric restriction greatly increases longevity in a small primate called the mouse lemur. Brain ; Health & life sciences Fontenay-aux-Roses Scientific result caloric restriction;gray matter; Fri, 20 Apr 2018 10:00:00 GMT A new success in gene therapy for beta thalassemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/New-success-in-gene-therapy-for-beta-thalassemia.aspx ​The efficacy of a gene therapy developed at the François Jacob Institute of Biology and Harvard University has been demonstrated in phase I/II clinical trials. Gene and cell therapy ; Genetic diseases Scientific result ; Press release Thu, 19 Apr 2018 10:00:00 GMT Huntington's disease and DCLK3: a vicious circle of gene transcription deregulation? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Huntington-DCLK3-vicious-circle-transcription-deregulation.aspx The results of a study performed by a research team at MIRCen suggest that the protein DCLK3 plays a key role in transcription regulation, and its deficit in Huntington's disease a key role in neurodegeneration. Neurodegenerative diseases ; Cellular mechanisms ; Molecular mechanisms Fontenay-aux-Roses Scientific result chromatin remodeling;transcription;DCLK3; Mon, 26 Mar 2018 10:00:00 GMT A summertime reduction in the plasma level of a peptide association with Alzheimer's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/summertime-reduction-plasmatic-amyloid-alzheimer.aspx Researchers from MIRCen have brought to light a reduction in the amount of an amyloid beta peptide associated with Alzheimer's disease in the plasma of a primate model during the summer season. Alzheimer's disease Fontenay-aux-Roses Scientific result Amyloid; Fri, 23 Mar 2018 11:00:00 GMT Theranexus signs partnership with the Collège de France https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2018/Theranexus-partnership-College-de-France.aspx Theranexus, a CEA-born biopharmaceutical company, signs a three-year research partnership agreement with the Collège de France. Pharmacology ; Brain Researchers ; general public ; Journalists Jacob Academic partnerships glial cells;narcolepsy;psychotropic medications; Thu, 15 Mar 2018 11:00:00 GMT Neurofibrillary tangles: a protective role in Alzheimer's disease? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/neurofibrillary-tangles-protective-role-alzheimer.aspx Neurofibrillary tangles are large aggregates of tau protein found in the neurons of people with Alzheimer's disease. Historically, they have been thought to be at least partially responsible for the pathology. However, the results of a study performed by researchers at MIRCen (François Jacob Institute of Biology/CEA) suggest to the contrary that neurofibrillary tangles may be protective. Alzheimer's disease ; Molecular mechanisms Fontenay-aux-Roses Scientific result neurofibrillary tangles;tau protein;hyperphosphorylation; Thu, 08 Mar 2018 11:00:00 GMT White fat, brown fat, and preventing obesity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/white-fat-brown-fat.aspx A team from the Innovative Therapies Unit (STI) has discovered a molecular mechanism that regulates the balance between white and brown fat. Their work defines a novel category of potential targets in the quest to control fat mass. Molecular mechanisms ; Cellular mechanisms Fontenay-aux-Roses Scientific result FOG-2;pRb;adipogenesis; Fri, 09 Feb 2018 11:00:00 GMT NeurATRIS : Call for collaborative projects on neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2018/Neuratris-call.aspx ​NeurATRIS lance un appel à projets pour initier des projets collaboratifs entre les membres de NeurATRIS, les laboratoires académiques et les sociétés de biotechnologies. A la clé, un financement à hauteur de 50K€. Diagnosis and innovative treatment ; Gene and cell therapy ; Neurodegenerative diseases News ; Academic partnerships ; Industrial partnerships Thu, 18 Jan 2018 11:00:00 GMT Hemoglobinopathies: a gene therapy modifies 100% of targeted cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Hemoglobinopathies-amelioration-therapie-genique.aspx ​The researchers at the François Jacob Institute's Department of Innovative Therapies are pursuing the development of their gene therapy for hereditary blood diseases. They are looking to increase the performance of their strategy so that it can bring benefits to the greatest number of patients possible. Genetic diseases ; Gene and cell therapy STI Scientific result Thu, 21 Dec 2017 11:00:00 GMT A researcher from the Institut François Jacob awarded the CNRS 2017 bronze medal https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2017/Une-chercheuse-de-institut-francois-jacob-medaille-de-bronze-CNRS-2017.aspx Carole Escartin, a researcher at the François Jacob Institute of Biology (IBFJ), has won the CNRS 2017 bronze medal. This medal rewards the first work of a researcher and represents an encouragement from the CNRS to pursue research that has already been productive. Neurodegenerative diseases ; Cellular mechanisms MIRcen Prizes and awards Fri, 24 Nov 2017 11:00:00 GMT Alzheimer's disease: a novel animal model https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Alzheimer-novel-animal-model.aspx A new animal model expresses the two biological characteristics of Alzheimer's disease, enabling new possibilities for treatment assessment and simplified diagnosis. Simulation & modelling ; Alzheimer's disease Researchers ; general public ; Journalists Fontenay-aux-Roses Scientific result Fri, 20 Oct 2017 10:00:00 GMT Sickle cell disease: remission of the signs of the disease in the first patient in the world treated with gene therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2017/Sickle-cell-disease-remission-signs-disease-first-patient-treated-gene-therapy.aspx A patient aged of 13 years with severe sickle cell disease has been treated succesfully by a gene therapy. This innovative treatment allowed complete remission of clinical signs of disease and correction of biological signs. Gene and cell therapy ; Genetic diseases ; Diagnosis and innovative treatment ; Health & life sciences general public ; Journalists ; Researchers Paris-Saclay Press release ; Scientific publications sickle cell anemia;Diagnosis and innovative treatment;Genetic diseases;Gene and cell therapy;Health & life sciences; Thu, 02 Mar 2017 00:00:00 GMT Chronic Myeloid Leukemia: a New Therapy Proves Successful https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Chronic-Myeloid-Leukemia-a-New-Therapy-Proves-Successful.aspx In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells—an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. Cancer ; Gene and cell therapy general public ; Journalists ; Researchers Jacob Scientific result Tue, 28 Feb 2017 11:00:00 GMT Discovery of a gene associated with radiosensitivity and post-radiotherapy complications https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2016/Discovery-of-a-gene-associated-with-radiosensitivity-and-post-radiotherapy-complications.aspx ​Scientists at the CEA’s Institute of Cellular and Molecular Radiation Biology, in collaboration with INSERM, Université Paris-Sud, and international partners, have demonstrated a connection between the expression of the TRAIL gene, which plays a role in cell death, and the radiosensitivity of certain human T lymphocytes. Health & life sciences ; Diagnosis and innovative treatment ; Cellular mechanisms Researchers ; general public DRF Press release ; Scientific result Mon, 21 Mar 2016 11:00:00 GMT Modulating cerebral cholesterol: a new avenue of research to treat Alzheimer’s disease? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2015/Modulating-cerebral-cholesterol-new-avenue-research-treat-Alzheimer.aspx Two French research teams have recently shown in a rodent model that overexpression of an enzyme capable of eliminating excess cholesterol in the brain can act in a beneficial way on the tau component of the disease to completely correct it. Alzheimer's disease ; Gene and cell therapy ; Biotechnology MIRcen Scientific result Mon, 14 Sep 2015 10:00:00 GMT