François Jacob Institute of biology - Sur le même thème https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/New-success-in-gene-therapy-for-beta-thalassemia.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - Sur le même thème https://jacob.cea.fr/drf/ifrancoisjacob/english LMN/MIRCen team wins "Équipe FRM 2023" accreditation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2023/lmn-mircen-frm-team.aspx Carole Escartin's Reactive Astrocytes team (UMR9199, Neurodegenerative Diseases Laboratory, MIRCen) has received the Équipe FRM 2023 label for its project on the role of astrocytes in the control of neuronal activity. Institutional ; Fundamental Research ; Brain ; Diagnosis and innovative treatment ; Gene and cell therapy ; Alzheimer's disease Researchers ; Journalists ; general public DRF Live in the center ; Highlight astrocytes;Alzheimer's Disease; Wed, 29 Mar 2023 10:00:00 GMT Beta thalassemia: toward a more effective therapeutic strategy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/beta-thalassemia-more-effective-therapeutic-strategy.aspx In a study published in Molecular Therapy, LCSAT (IDMIT, CEA-Jacob) researchers present a novel, optimized, lentiviral gene therapy for β-thalassemia. Gene and cell therapy Researchers ; general public ; Journalists STI Scientific result ; Highlight lentiglobin;lentiviral gene therapy;beta-thalassemia;he; Thu, 20 May 2021 10:00:00 GMT Two technologies are better than one for understanding Huntington's disease https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Two-technologies-for-understanding-Huntington-s-disease.aspx Researchers at MIRCen (CEA-Jacob) combined spectroscopy and metabolic imaging to identify novel biomarkers for Huntington's disease. Their approach enables the monitoring of disease course and may prove useful for exploring other neurodegenerative diseases or testing future treatments. Neurodegenerative diseases ; Genetic diseases ; MRI ; Cell and molecular imaging Researchers ; general public ; Journalists MIRcen Scientific result ; Highlight glutamate;gluCEST;huntington;NMR;neurodegenerative diseases; Fri, 31 Jul 2020 10:00:00 GMT Rapid genome analysis provides invaluable aid for hospitalized newborns https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Rapid-genome-analysis-provides-invaluable-aid-for-hospitalized-newborns.aspx In their work entitled Fastgenomics, the Dijon Bourgogne University Hospital, Inserm and the CEA's National Center of Human Genomics Research (CNRGH) studied a rapid high-throughput genome sequencing process in 30 hospitalized newborns. The team was able to reduce the time needed for this process from an average of 18 months to only a month and a half at most (38 to 49 days), thus enabling rapid diagnoses for two-thirds of the patients. Genetic diseases ; Diagnosis Researchers ; Journalists DRF Highlight ; News ; Scientific result Genetic diseases;Gene Sequence; Wed, 18 Dec 2019 11:00:00 GMT New knowledge for cell therapies in neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/New-knowledge-for-cell-therapies-in-neurodegenerative-diseases.aspx MIRCen contributed to a study that showed that the use of histocompatible neuronal grafts did not eliminate the need for immunosuppressive drugs in a primate model. Those results provide important knowledge for the clinical use of certain cell therapies under development for the treatment of neurodegenerative diseases. Brain ; Neurodegenerative diseases ; Gene and cell therapy Scientific result Wed, 09 Oct 2019 10:00:00 GMT A new generation of lentivirus for gene therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-new-generation-of-lentivirus-for-gene-therapy.aspx Researchers from STI have developed a new generation of lentivirus, paving the way for the use of Mauritian cynomolgus macaque as a pre-clinical study model for the development of new gene therapy products. Health & life sciences ; Gene and cell therapy Researchers ; Journalists STI Highlight ; Scientific result DNA;Gene and cell therapy;pre-clinical; Mon, 22 Jul 2019 10:00:00 GMT Alzheimer's disease: blocking reactive astrocytes to help neurons https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Alzheimer-disease-blocking-reactive-astrocytes-help-neurons.aspx Researchers from MIRCen have shown that inhibiting reactive astrocytes is beneficial for certain characteristics of Alzheimer's disease. Their results could lead to novel therapies that act upon astrocytes to improve neuron function. Brain ; Gene and cell therapy ; Alzheimer's disease ; Cellular mechanisms Paris-Saclay Scientific result Alzheimer;astrocytes;neuron; Mon, 29 Oct 2018 11:00:00 GMT A new success in gene therapy for beta thalassemia https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/New-success-in-gene-therapy-for-beta-thalassemia.aspx ​The efficacy of a gene therapy developed at the François Jacob Institute of Biology and Harvard University has been demonstrated in phase I/II clinical trials. Gene and cell therapy ; Genetic diseases Scientific result ; Press release Thu, 19 Apr 2018 10:00:00 GMT NeurATRIS : Call for collaborative projects on neurodegenerative diseases https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2018/Neuratris-call.aspx ​NeurATRIS lance un appel à projets pour initier des projets collaboratifs entre les membres de NeurATRIS, les laboratoires académiques et les sociétés de biotechnologies. A la clé, un financement à hauteur de 50K€. Diagnosis and innovative treatment ; Gene and cell therapy ; Neurodegenerative diseases News ; Academic partnerships ; Industrial partnerships Thu, 18 Jan 2018 11:00:00 GMT Hemoglobinopathies: a gene therapy modifies 100% of targeted cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Hemoglobinopathies-amelioration-therapie-genique.aspx ​The researchers at the François Jacob Institute's Department of Innovative Therapies are pursuing the development of their gene therapy for hereditary blood diseases. They are looking to increase the performance of their strategy so that it can bring benefits to the greatest number of patients possible. Genetic diseases ; Gene and cell therapy STI Scientific result Thu, 21 Dec 2017 11:00:00 GMT Cows: the new stars of research? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Cows-new-stars-research.aspx A new study involving the François Jacob Institute of Biology shows that cows too can be a pertinent model for the study of human genetic abnormalities. Simulation & modelling ; Genetic diseases Researchers ; general public ; Journalists Fontenay-aux-Roses Scientific result Fri, 20 Oct 2017 10:00:00 GMT Sickle Cell Disease: Remission in the First Patient Treated by Gene Therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/sickle-cell-disease-remission-first-patient-treated-by-gene-therapy.aspx A patient with severe sickle cell disease has undergone gene therapy developed at the CEA François-Jacob Institute. Two years after treatment, the remission of clinical signs was complete. Health & life sciences ; Genetic diseases ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Thu, 02 Mar 2017 11:00:00 GMT Sickle cell disease: remission of the signs of the disease in the first patient in the world treated with gene therapy https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2017/Sickle-cell-disease-remission-signs-disease-first-patient-treated-gene-therapy.aspx A patient aged of 13 years with severe sickle cell disease has been treated succesfully by a gene therapy. This innovative treatment allowed complete remission of clinical signs of disease and correction of biological signs. Gene and cell therapy ; Genetic diseases ; Diagnosis and innovative treatment ; Health & life sciences general public ; Journalists ; Researchers Paris-Saclay Press release ; Scientific publications sickle cell anemia;Diagnosis and innovative treatment;Genetic diseases;Gene and cell therapy;Health & life sciences; Thu, 02 Mar 2017 00:00:00 GMT Chronic Myeloid Leukemia: a New Therapy Proves Successful https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/Chronic-Myeloid-Leukemia-a-New-Therapy-Proves-Successful.aspx In a phase 2 clinical trial, scientists showed the efficiency of targeting cancer stem cells—an approach imagined and developed at the CEA François-Jacob Institute for the treatment of leukemia, chronic myeloid leukemia in particular. Cancer ; Gene and cell therapy general public ; Journalists ; Researchers Jacob Scientific result Tue, 28 Feb 2017 11:00:00 GMT Modulating cerebral cholesterol: a new avenue of research to treat Alzheimer’s disease? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2015/Modulating-cerebral-cholesterol-new-avenue-research-treat-Alzheimer.aspx Two French research teams have recently shown in a rodent model that overexpression of an enzyme capable of eliminating excess cholesterol in the brain can act in a beneficial way on the tau component of the disease to completely correct it. Alzheimer's disease ; Gene and cell therapy ; Biotechnology MIRcen Scientific result Mon, 14 Sep 2015 10:00:00 GMT