François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/inflammation-Covid-19-HLA-G-checkpoint-immune-surveillance.aspx Website of the François Jacob Institute of Biology en-US https://jacob.cea.fr/drf/ifrancoisjacob/SiteAssets/logo-cea-JACOB.png François Jacob Institute of biology - On the same theme https://jacob.cea.fr/drf/ifrancoisjacob/english A passive immunization approach prevents SHIV infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/passive-immunization-shiv-infection.aspx In a study published in Nature Communications, IDMIT researchers demonstrated the efficacy of a neutralizing antibody against cell-associated infection by simian-human immunodeficiency virus. AIDS ; Infectious diseases ; Vaccine Researchers ; Journalists DRF Scientific result ; Highlight immunization;SHIV;HIV;preclinical studies;Antibody;bNAb;AIDS; Wed, 01 Nov 2023 11:00:00 GMT Rad51-mediated homologous recombination: insights into aging and tumorigenesis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/rad-medited-homologous-recombination-aging-tumorigenesis.aspx Using a murine preclinical model wherein Rad51 was selectively inhibited, researchers from the Laboratory of Development of the Gonads (iRCM:CEA-Jacob) and the Institut Cochin showed that in vivo alteration of Rad51-mediated homologous recombination does not favor the development of cancers, it reduces it. The team's work was published in The Embo Journal. Cellular mechanisms ; Stress response ; DNA Researchers ; Journalists IRCM Scientific result ; Highlight DNA;homologous recombination;premature aging; Wed, 18 Oct 2023 10:00:00 GMT The nuclear pore: a safe place for gene expression https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/nuclear-pore-safe-place-gene-expression.aspx In an article published in Nature Communications, researchers from Institut Jacques-Monod and iRCM (CEA-Jacob) merged imaging and biochemistry approaches to show that the genes involved in expression are conducted to nuclear pores in order to protect the genome. DNA ; Cellular mechanisms ; Molecular mechanisms Researchers ; Journalists IRCM Highlight ; Scientific result R-loop;RNA;gene;nuclear; Tue, 03 Oct 2023 10:00:00 GMT COVID-19: targeting the nuclear ACE2 pathway in SARS-CoV-2 infection https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/covid-receptor-ace-infection.aspx In a new study published in Nature Communications, researchers from IDMIT and the QIMR Berghofer Institute have shown that a peptide able to inhibit the nuclear ACE2 receptor provides protection against SARS-CoV-2 infection. Infectious diseases Researchers ; Journalists DRF Highlight ; Scientific result Inflammation;infection;COVID-19;SARS-CoV-2;nace2i;ace2;preclinical studies;infectious diseases; Wed, 19 Jul 2023 10:00:00 GMT Sotrovimab remains efficacious against the BQ.1.1 omicron subvariant of SARS-CoV-2 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/Sotrovimab-efficacious-omicron-subvariant-sars-cov-2.aspx In a study published in Heliyon, researchers from IDMIT (CEA-Jacob) used a well-characterized non-human primate model to show that sotrovimab is efficacious against the BQ.1.1 subvariant of SARS-CoV-2. Their results lend support for the continued use of sotrovimab in patients ineligible for nirmatrelvir/ritonavir. Infectious diseases ; Virus Researchers ; general public ; Journalists IDMIT Highlight ; Scientific result COVID-19;Monoclonal antibodies;subvariants;omicron;SARS-CoV-2; Wed, 05 Jul 2023 10:00:00 GMT An Alzheimer's model to study the propagation of the pathological forms of tau https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/Alzheimer-propagation-forms-pathological-Tau-.aspx In an article published in Neurobiology of Disease, researchers from MIRCen's Neurodegenerative Diseases Laboratory present a novel model of Alzheimer's disease that enables the study of tauopathy inter-neuronal propagation mechanisms, the identification of new therapeutic targets and the exploration of new treatments. Neurodegenerative diseases ; Alzheimer's disease ; Cellular mechanisms Researchers ; general public ; Journalists MIRcen Highlight ; Scientific result Alzheimer Disease;Cellular biology;tau protein;AAV; Fri, 16 Jun 2023 10:00:00 GMT XLF/Cernunnos: premature neurogenesis and delayed brain development https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/xlf-cernunnos-premature-neurogenesis-brain-development.aspx In a work published in Cell Reports, researchers from the SGCSR mixed research unit (IRCM) have shown that the loss of XLF (a.k.a. Cernunnos), a component of the non-homologous end-joining complex, severely alters brain development and function in mice. Cellular mechanisms ; Stem cells ; Stress response ; Brain ; Cell division Researchers ; general public ; Journalists IRCM Highlight ; Scientific result neural progenitor cells;DNA repair;genome stability;mitosis;NHEJ;neurogenesis;microcephaly;brain development; Fri, 21 Apr 2023 10:00:00 GMT A model to better understand oogenesis and female infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/model-oogenesis-femaile-infertility.aspx In a work published in Cells, researchers from LDG (IRCM) used human induced pluripotent stem cells to develop an in vitro model capable of reproducing the early stages of oogenesis. Cellular mechanisms ; Stem cells ; Cell division Researchers ; Journalists ; general public SCSR Highlight ; Scientific result induced pluripotent stem cells;oogenesis;infertility;primordial germ cells;podoplanin;model; Thu, 16 Mar 2023 11:00:00 GMT MXD4/MAD4 : a target of interest for ex vivo stem cell preservation https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2023/MXD4-MAD4-stel-cell-preservation.aspx In a study published in the Journal of Investigative Dermatology, researchers from LGRK (iRCM) identified the transcription factor MXD4/MAD4 as an element of the pathway regulating the stemness of keratinocyte precursors and their skin regeneration capacities. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public DRF Scientific result ; Highlight MXD4/MAD4;bioengineering;skin;skin repair;graft;stemness;cutaneous; Fri, 03 Feb 2023 11:00:00 GMT On the path toward a chikungunya vaccine https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/chikungunya-vaccine.aspx In a study published in JCI Insight, researchers from IDMIT have demonstrated the vaccinal effectiveness of serum transfers from volunteers vaccinated against the chikungunya virus to an animal model. This work is an important step toward vaccine marketing approval, as the nature of chikungunya epidemics hampers the deployment of conventional efficacy trials. Health & life sciences ; Vaccine ; Infectious diseases ; Chikungunya Researchers ; Journalists DRF Scientific result ; Highlight vaccine;chikungunya;idmit; Fri, 16 Dec 2022 11:00:00 GMT An in vitro model to study infertility https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/in-vitro-model-study-infertility.aspx In a work published in Scientific Reports, researchers from IRCM, the Sup'Biotech/SEPIA partnership lab and Imagine Institute teamed to develop an in vitro, model of infertility wherein induced pluripotent stem cells generated from the erythroblasts of infertile men presenting genetic abnormalities were used to successfully generate primordial germ-like cells. Diagnosis and innovative treatment ; Stem cells Researchers ; Journalists ; general public IRCM Highlight ; Scientific result stem cells;infertility;azoospermia; Mon, 28 Nov 2022 11:00:00 GMT IDMIT Director Roger Le Grand joins the new Committee For Health Risk Monitoring and Anticipation (COVARS) https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2022/Roger-Le-Grand-member-COVARS.aspx IDMIT (CEA-Jacob) Director Roger Le Grand has joined COVARS, a consultative body to guide decisions made by public entities on the anticipation, prevention and human consequences of health crises. Science & society ; Infectious diseases ; Institutional Researchers ; Journalists ; general public DRF Live in the center ; Highlight zoonotic disease;human infectious diseases;scientific committee;COVARS; Fri, 14 Oct 2022 10:00:00 GMT Does the menstrual cycle affect the risk of STIs? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/menstrual-cycle-risk-STI.aspx Researchers from IDMIT describe the course of immune & inflammatory markers and the vaginal microbiome during the menstrual cycle. Infectious diseases ; Cellular mechanisms ; Immune system Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight bacteria;HIV;HIV-AIDS;Infectious Disease;immune response;cellular immune responses;viruses;therapy; Fri, 20 May 2022 10:00:00 GMT ComFC, a key protein in the transmission of antibiotic resistance among bacteria https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/ComFC-transmission-antibiotic-resistance-bacteria.aspx A team of researchers from IRCM (CEA-Jacob) and I2BC have shed light on the role of ComFC, a bacterial protein involved in natural transformation, itself a driving mechanism for the propagation of antibiotic resistance genes and virulence factors. Cellular mechanisms ; Molecular mechanisms ; Antibiotics Researchers ; general public ; Journalists SCSR Highlight ; Scientific result bacteria;Antibiotic;Antibiotic Resistance;Molecular mechanisms; Tue, 19 Apr 2022 10:00:00 GMT A protein-based candidate vaccine prevents SARS-CoV-2 transmission in preclinical trials https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/protein-candidate-vaccine-prevents-SARS-CoV-2.aspx Preclinical trials carried out as part of a CEA-Irig–CEA-Jacob partnership have shown that a spike-protein-based candidate vaccine provides complete protection against SARS-CoV-2 infection. Infectious diseases Researchers ; Journalists ; general public IDMIT Scientific result ; Highlight COVID-19;Spike;SARS-CoV-2;vaccine;preclinical research;Lipids; Mon, 21 Feb 2022 11:00:00 GMT Inflammation and COVID-19: the HLA-G immune checkpoint under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2022/inflammation-Covid-19-HLA-G-checkpoint-immune-surveillance.aspx In a study published in Viruses, a team of researchers from SRHI and the University of Ferrara (Italy) showed that the soluble form of HLA-G may contribute significant anti-inflammatory properties via its role in controlling the adhesion of neutrophils to endothelial cells and thus improve disease outcome in patients with COVID-19. Infectious diseases ; Cellular mechanisms Researchers ; Journalists ; general public SRHI Scientific result ; Highlight HLA-G;COVID-19;endothelial cells;Angiogenesis;neutrophil; Tue, 11 Jan 2022 11:00:00 GMT COVID-19 durably affects the intestinal microbiota https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/COVID-19-affects-intestinal-microbiota.aspx The microbial composition and metabolome of the intestinal microbiota of an animal model for COVID-19 were altered over the disease course and remained so after the resolution of lung infection. Those results, which will contribute were brought to light by the Institut Pasteur in Lille in partnership with IDMIT (CEA-Jacob). Infectious diseases ; Metagenomics Researchers ; Journalists ; general public DRF News ; Scientific result dysbiosis;intestinal microbiota;COVID 19;SARS-CoV2; Wed, 05 May 2021 10:00:00 GMT Targeting HIF1α or JMY in glioblastoma: if not one why not the other? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/HIF1-JMY-glioblastoma-targeting.aspx Glioblastomas are highly aggressive brain tumors with a very poor prognosis. Even with aggressive treatment, recurrence is nearly systematic. Researchers from IRCM (CEA-Jacob) have decrypted molecular mechanisms that enable treatment resistance and escape for a subpopulation of cells. Brain ; Cancer ; Stem cells Researchers ; Journalists ; general public SCSR Highlight ; Scientific result Brain;glioblastoma;Cancer;invasion;Tumor;ionizing radiations;HIF1α; Thu, 01 Apr 2021 10:00:00 GMT Preclinical study sheds light on a new vaccine candidate for Covid-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2021/preclinical-study-sheds-light-new-vaccine-candidate-Covid-19.aspx A new international study, published in Cell, co-leaded by IDMIT (CEA-Jacob) and the Department of Medical Microbiology of the University of Amsterdam, presents the results of preclinical trials of a new protein vaccine candidate against Covid-19. Infectious diseases ; Virus ; Vaccine Researchers ; Journalists ; general public DRF Highlight ; Scientific result COVID 19;SARS-CoV-2;vaccine;Nanoparticles;Preclinical; Mon, 08 Mar 2021 11:00:00 GMT The journal L'Édition of Université Paris-Saclay shines a light on stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2021/stem-cells-Edition-Universite-Paris-Saclay.aspx Read about the contributions of two François Jacob Institute of Biology laboratories in an article on human stem cells and their use in research published in the most recent edition of the journal L'Édition of Université Paris-Saclay. The article discusses the interest of stem cells for the development of novel disease models and potential therapies. Stem cells Researchers ; Journalists ; general public IRCM Live in the center stem cells; Sun, 14 Feb 2021 11:00:00 GMT Immune response: not all are equal in interferon β production https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Immune-response-not-all-equal-interferon-beta-production.aspx Researchers from IRCM (CEA-Jacob) have identified a DNA sequence polymorphism that leads to reduced production of interferon β by myeloid cells. The substitution, which is present in about 30% of the population, could affect immune response to infections and tumors. Molecular mechanisms ; Cancer ; Infectious diseases ; Immune system Researchers ; general public ; Journalists IRCM Scientific result ; Highlight radiation-induced tumor;myeloid cells;infection;immunity;regulation of gene expression;virus;polymorphism; Wed, 18 Nov 2020 11:00:00 GMT A breakthrough in the understanding of natural HIV infection control mechanisms https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/breakthrough-understanding-natural-HIV-infection-control-mechanisms.aspx Researchers from IDMIT (CEA-Jacob) and the Institut Pasteur teamed for a study in which they showed that the antiviral activity of CD8+ T lymphocytes remained limited in the first two weeks of infection but grew progressively and durably thereafter in macaques able to control simian immunodeficiency virus infection (the equivalent of HIV infection in non-human primates). Their results suggest that the early development of highly effective memory CD8+ T-cells is essential for achieving viral control. Diagnosis and innovative treatment ; Vaccine ; Infectious diseases ; AIDS ; Virus Researchers ; general public ; Journalists IDMIT Highlight ; Scientific result HIV-AIDS;HIV;vaccine;human infectious diseases;SIV;lymphocytes;Immune system; Thu, 08 Oct 2020 10:00:00 GMT Skin and ionizing radiation: sensitivity under surveillance https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/skin-ionizing-radiation-sensitivity-under-surveillance.aspx In a study published in Cells, researchers from LGRK (IRCM/CEA-Jacob) showed that human skin stem cells are sensitive to low doses of genotoxic stress in the setting of active regeneration. Stem cells ; Radiobiology ; Radiosensitivity ; Radiotherapy Researchers ; Journalists DRF Scientific result ; Highlight epidermis;skin;organoids;ionizing radiation;keratinocyte stem cells;medical imaging;radiosensitivity; Wed, 07 Oct 2020 10:00:00 GMT Experimental models and Covid-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/experimental-models-Covid-19.aspx The COVID-19 pandemic has underlined how important intense preclinical research is to the development and validation of therapeutics. In this context, a WHO-mandated group of experts, including Roger le Grand and Pauline Maisonnasse from IDMIT (CEA-Jacob), have published an article in Nature that presents existing COVID-19 animal models and explores their pertinence for studying the pathology and identifying paths toward novel treatments for it. Infectious diseases ; Virus general public ; Researchers ; Journalists DRF Scientific result coronavirus;viral infectious;animal models;COVID 19;experimental models;preclinical studies; Fri, 02 Oct 2020 10:00:00 GMT Hydroxychloroquine and preclinical studies: a world tour in five experimental models https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Hydroxychloroquine-preclinical-studies-world-tour-five-experimental-models.aspx An international study involving IDMIT's (CEA-Jacob) Roger Le Grand and other researchers from more than 80 countries concluded that chloroquine and hydroxychloroquine likely provide no clinical benefits in the treatment of COVID-19. Infectious diseases ; Virus Researchers ; Journalists ; general public DRF Scientific result ; Highlight preclinical studies;pathology modeling;COVID-19;chloroquine;hydroxychloroquine;human infectious diseases; Fri, 28 Aug 2020 10:00:00 GMT Launch of Corona Accelerated R&D in Europe: IDMIT steps up to the plate https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Launch-of-CARE-program-IDMIT-steps-up-to-the-plate.aspx IDMIT (CEA-Jacob) is participating in CARE, a public-private consortium of 37 organizations brought together to speed the development of treatments for COVID-19 and future coronavirus epidemics. Infectious diseases ; Virus ; Diagnosis and innovative treatment Journalists ; Researchers ; general public IDMIT News ; Headlines research;european project;Europe;funding;COVID 19;vaccine;consortium;infectious diseases; Thu, 27 Aug 2020 10:00:00 GMT Anti-HIV antibodies: predicting in vivo efficacy in vitro https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Anti-HIV-antibodies-predicting-in-vivo-efficacy-in-vitro.aspx A study performed by an IDMIT team (CEA-Jacob) has resulted in an in vitro approach for predicting the in vivo efficacy of antibodies used for the prevention of HIV-1 transmission. The work identified antibodies capable of efficaciously blocking intercellular viral transmission in infected semen. Vaccine ; AIDS ; Infectious diseases ; Diagnosis and innovative treatment ; Biotechnology ; Virus Researchers ; general public ; Journalists IDMIT Scientific result ; Highlight intercellular transmission;sperm;vaccine;Antibody;HIV;AIDS; Fri, 07 Aug 2020 10:00:00 GMT Questioning COVID-19 and hydroxychloroquine: a new preclinical study https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/questioning-COVID-19-hydroxychloroquine-new-preclinical-study.aspx A new preclinical study piloted by IDMIT and employing experimental infection models for SARS-CoV-2 found no therapeutic antiviral efficacy for hydroxychloroquine. The team behind the study tested the compound both alone and in combination with azithromycin, and as a prophylactic and in early and late infection. Their results have been published on Nature. Virus ; Infectious diseases Journalists ; Researchers ; general public DRF Scientific result ; Highlight COVID 19;SARS-CoV-2;virus;virology;idmit;translational approaches;preclinical research;azythromycine; Wed, 22 Jul 2020 10:00:00 GMT The brain: a careful balance between stability and genetic variability https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/The-brain-balance-stability-variability.aspx In a study published in DNA Repair, an IRCM (CEA-Jacob) team has elucidated mechanisms through which neural stem and progenitor cells maintain genome integrity more efficaciously than other cell types. The team's work contributes to a better understanding of the high-fidelity transmission of genetic information so crucial to brain development. Brain ; DNA ; Stem cells ; Stress response Researchers ; general public ; Journalists DRF Scientific result ; Highlight adaptive response;chromosome stability;genetic diversity;neural progenitor cells;Brain;DNA repair;development;radiation;genotoxic stress;non-homologous end-joining;Neural stem cells; Mon, 20 Jul 2020 10:00:00 GMT HIV transmission: a role for genital tract inflammation and immunity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/HIV-transmission-inflammation-immunity.aspx In a study on the HIV-specific immune response in semen, published in Frontiers in Immunology, researchers from IDMIT (CEA-Jacob) have shed light on a complex interaction between immunity and inflammation in modulating semen infectivity and the risk of HIV transmission. Infectious diseases ; AIDS Researchers ; general public ; Journalists Jacob Scientific result ; Highlight Inflammation;immunity;HIV-AIDS;infectious diseases;HIV;AIDS;human infectious diseases; Tue, 07 Jul 2020 10:00:00 GMT COVID-19: two projects retained for the Paris-Saclay University exceptional research program https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/COVID-19-two-projects-retained-Paris-Saclay-University-exceptional-research-program.aspx Paris-Saclay University as well as its component institutions and member-associated universities , their partner national research organisms, and the LERMIT, CHARMMMAT, LASIPS and NanoSaclay laboratories of excellence (LabExs) collectively decided to release funds for research projects targeting the COVID-19 pandemic. Among the laureates are the CNRGH and IRCM, with their respective projects COVIDOGEN and BIOTHETARCOVI. Infectious diseases Researchers ; Journalists ; general public DRF Highlight Inflammation;COVID 19;LRTS;CNRGH;idmit;iRCM; Sun, 21 Jun 2020 10:00:00 GMT Flash ANR Covid-19: IDMIT engaged in a project selected by the ANR https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Flash-ANR-Covid-19-IDMIT-engaged-in-a-project-selected-by-the-ANR.aspx As a part of the Covid-19 Flash call launched on March 6, 2020, the ANR selected 86 research projects for immediate funding, covering a large number of issues related to the Covid-19 epidemic. Among the selected projects, one project coordinated by Roger Le Grand (IDMIT) focuses on the study of the pathogenesis of the SARS-Cov-2 infection in a pre-clinical study model. Infectious diseases ; Virus Researchers ; Journalists DRF Highlight coronavirus;COVID 19; Sun, 12 Apr 2020 10:00:00 GMT Innate immune memory and vaccination: a controlled schedule for improved benefit https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Innate-immune-memory-and-vaccination-a-controlled-schedule-for-improved-benefit.aspx A study led by IMVA-HB/IDMIT researchers, published in NPJ Vaccines, has shown the influence of the delay between vaccinations (primary and booster) on the specific humoral immune response. This work also suggests the establishment of a trained immune memory. Vaccine ; Infectious diseases ; Immune system Researchers ; Journalists DRF Highlight ; News ; Scientific result immunization;immune response;vaccine;Immune memory;Immune system;Vaccination Immunogenicity; Thu, 19 Mar 2020 11:00:00 GMT Combining genetic engineering and stem cells to obtain tailormade "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2020/Combining-genetic-engineering-and-stem-cells-to-obtain-tailormade-mini-brains.aspx Researchers from the SEPIA (CEA)-Sup'Biotech partnership laboratory and the Gly-CRRET (UPEC) laboratory have developed a genetic tool for the long-term expression of proteins in human brain organoids. This work, published in Frontiers in Cellular Neuroscience, concerns the modelling of a genetic form of frontotemporal dementia, a neurodegenerative disease with a tauopathic side similar to Alzheimer's disease. Stem cells ; Neurodegenerative diseases Researchers ; Journalists Jacob Highlight ; Scientific result ; News Alzheimer Disease;neurodegenerative diseases;gene expression;stem cell;episomal plasmid;cerebral organoids; Wed, 18 Mar 2020 11:00:00 GMT IDMIT on point against COVID-19 https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/IDMIT-on-point-against-COVID-19.aspx With the support of the Ministry of Solidarity and Health and the Ministry of Higher Education, Research and Innovation, 20 scientific initiatives were selected by REACTing's scientific board and presented at a press conference on 11 March. Among them, IDMIT is piloting a fundamental research project on the evolution of Covid-19 in a specific pre-clinical study model. Infectious diseases Researchers ; Journalists DRF Highlight ; News virus;Infectious Disease;idmit; Fri, 13 Mar 2020 11:00:00 GMT European research gets organised against tuberculosis https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/European-research-gets-organised-against-tuberculosis.aspx To develop new treatments for tuberculosis, the world's leading cause of death from infectious diseases, the European Union and the European Federation of Pharmaceutical Industries and Associations are launching the ERA4TB (European Regimen Accelerator for Tuberculosis) consortium combining academic and private research, of which the IDMIT department is a partner Infectious diseases Researchers ; Journalists DRF Highlight ; News tuberculosis;Tuberculosis Bacterium;Infectious Disease; Mon, 17 Feb 2020 11:00:00 GMT Le Monde immersed in the world of "mini-brains" https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2020/Le-Monde-immersed-in-the-world-of-mini-brains.aspx On February 12th, a dossier on cerebral organoids was published in the Cahier Sciences et Médecine of the newspaper Le Monde: "Cerebroids: from mini-organs to maxi-powers ?" Report in the SEPIA/Sup'Biotech partnership laboratory. Neurodegenerative diseases ; Stem cells Researchers ; Journalists DRF Highlight Sun, 16 Feb 2020 11:00:00 GMT Helicobacter pylori: please don't share… https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Helicobacter-pylori-please-do-not-share.aspx ...or how finding the unique link may be a path toward curing gastric infections. In a study published in Nature Communications, researchers from LRIG (IRCM) identified a protein that is essential for an antibiotic resistance propagation pathway in the bacterium Helicobacter pylori. Infectious diseases ; Bacteria Researchers ; Journalists Highlight ; News ; Scientific result recombination;DNA repair;bacteria;infectious diseases;Helicobacter pylori; Thu, 28 Nov 2019 11:00:00 GMT On track to eradicating stomach infections in half the world's population https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/On-track-to-eradicating-stomach-infections-in-half-the-world's-population.aspx Health & life sciences ; Diseases ; Bacteria ; Infectious diseases News ; Press release ; Focus Wed, 27 Nov 2019 11:00:00 GMT A bit of air please... https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/A-bit-of-air-please-.aspx ...or how small amounts of oxygen contribute to the preservation of lymphocyte progenitors in humans. In an article published in Cell Reports, researchers from LSHL (IRCM) shared new findings on the role of hypoxia in human lymphocyte differentiation. Stem cells ; Immune system Researchers ; Journalists Jacob News ; Highlight ; Scientific result hematopoietic differentiation;T lymphocytes;Hematopoietic stem cells;hypoxia;Immune system; Tue, 19 Nov 2019 11:00:00 GMT Skin graft: a new molecular target for activating stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/Skin-graft-a-new-molecular-target-for-activating-stem-cells.aspx Fundamental Research ; Health & life sciences ; Cellular mechanisms ; Stem cells ; Genomics Press release ; Highlight ; Article ; Scientific result ; Success ; Focus Wed, 23 Oct 2019 10:00:00 GMT Skin grafts: KLF4, a new target for activating skin stem cells https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Skin-grafts-KLF4-new-target-for-activating-skin-stem-cells.aspx In a study published in Nature Biomedical Engineering, a team from the Genomics and Radiobiology of Keratinopoiesis laboratory (LGRK/ IRCM) has shown that a transcription factor, KLF4, plays a key role in the proliferation of the stem cells in the epidermis. The discovery brings new therapeutic perspectives to regenerative medicine. Stem cells Researchers ; Journalists Jacob Scientific result ; Highlight ; News skin;keranocytes;stem cell;graft;cell therapy;keratinocyte stem cells; Tue, 22 Oct 2019 10:00:00 GMT The genome of the pea assembled for the first time https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2019/The-genome-of-the-pea-assembled-for-the-first-time.aspx Fundamental Research ; Science & society ; Health & life sciences ; Methodologies for life sciences ; Molecular mechanisms ; Cellular mechanisms ; Genomics Press release ; News ; Focus Tue, 03 Sep 2019 10:00:00 GMT The brain: a key participant in the development of cancer? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/The-brain-a-key-participant-in-the-development-of-cancer.aspx A French team from IRCM (CEA/Inserm) recently published a study in the scientific journal Nature showing that neurons can develop within the tumoral microenvironment and thus contribute to the development of certain types of cancer. Brain ; Cancer ; Health & life sciences ; Cellular mechanisms Researchers ; Journalists ; general public Paris-Saclay Scientific publications ; Scientific result ; News health;Cancer;neural network;Brain;neuron;neurosciences; Fri, 17 May 2019 10:00:00 GMT The Arctic Ocean: a "hot spot" of viral diversity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/The-Arctic-Ocean-a-hot-spot-of-viral-diversity.aspx A study on data collected largely by the Tara Oceans expedition has provided the most complete catalog to date of the viruses present in the world's oceans —and earned a place on the front page of the scientific journal Cell. The results reveal the key role of the Arctic Ocean as a reservoir for marine viruses. Climate ; Fundamental Research ; Oceanography ; Climatic models ; Virtual reality, augmented reality ; Cellular mechanisms Researchers ; Journalists ; general public Paris-Saclay News ; Scientific publications ; Scientific result sequencing;Tara Oceans;plankton;expedition;genomic sequencing;Climat;Arctique;virus; Thu, 25 Apr 2019 10:00:00 GMT Astrocytic mitochondria help you remember https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2019/Astrocytic-mitochondria-memory.aspx With help from MIRCen, an international team has shown that the mitochondria of astrocytes (neuron support cells) intervene in the regulation of memory. Brain ; Neurodegenerative diseases ; Cellular mechanisms general public ; Researchers ; Journalists Paris-Saclay Scientific result neurons;mitochondria;astrocytes;memory;Brain;neurosciences; Thu, 28 Mar 2019 11:00:00 GMT Alzheimer's disease: blocking reactive astrocytes to help neurons https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Alzheimer-disease-blocking-reactive-astrocytes-help-neurons.aspx Researchers from MIRCen have shown that inhibiting reactive astrocytes is beneficial for certain characteristics of Alzheimer's disease. Their results could lead to novel therapies that act upon astrocytes to improve neuron function. Brain ; Gene and cell therapy ; Alzheimer's disease ; Cellular mechanisms Paris-Saclay Scientific result Alzheimer;astrocytes;neuron; Mon, 29 Oct 2018 11:00:00 GMT New function discovered for the protein Rad52, a serious therapeutic target in breast cancer https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/New-function-discovered-protein-Rad52-serious-therapeutic-target-breast-cancer.aspx Rad52 has garnered great attention lately as a promising target in the battle against certain types of breast cancer. A team from IRCM, in partnership with researchers from the Frédéric-Joliot and Gustave Roussy Institutes, has shed new light on this protein. Stress response ; Molecular mechanisms Jacob Scientific result Rad51 filament;budding yeast;Srs2; Fri, 12 Oct 2018 10:00:00 GMT Huntington's disease and DCLK3: a vicious circle of gene transcription deregulation? https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/Huntington-DCLK3-vicious-circle-transcription-deregulation.aspx The results of a study performed by a research team at MIRCen suggest that the protein DCLK3 plays a key role in transcription regulation, and its deficit in Huntington's disease a key role in neurodegeneration. Neurodegenerative diseases ; Cellular mechanisms ; Molecular mechanisms Fontenay-aux-Roses Scientific result chromatin remodeling;transcription;DCLK3; Mon, 26 Mar 2018 10:00:00 GMT White fat, brown fat, and preventing obesity https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2018/white-fat-brown-fat.aspx A team from the Innovative Therapies Unit (STI) has discovered a molecular mechanism that regulates the balance between white and brown fat. Their work defines a novel category of potential targets in the quest to control fat mass. Molecular mechanisms ; Cellular mechanisms Fontenay-aux-Roses Scientific result FOG-2;pRb;adipogenesis; Fri, 09 Feb 2018 11:00:00 GMT A researcher from the Institut François Jacob awarded the CNRS 2017 bronze medal https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Other-News/2017/Une-chercheuse-de-institut-francois-jacob-medaille-de-bronze-CNRS-2017.aspx Carole Escartin, a researcher at the François Jacob Institute of Biology (IBFJ), has won the CNRS 2017 bronze medal. This medal rewards the first work of a researcher and represents an encouragement from the CNRS to pursue research that has already been productive. Neurodegenerative diseases ; Cellular mechanisms MIRcen Prizes and awards Fri, 24 Nov 2017 11:00:00 GMT HIV "elite controllers" starting to share their secrets https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/HIV-Elite-controllers.aspx What are the mechanisms preventing viral progression in HIV "elite controllers"? Researchers at the François Jacob Institute of Biology and their partners have shed light on some particularities of CD8+ T cells. AIDS Researchers ; general public ; Journalists Jacob Scientific result Fri, 28 Jul 2017 10:00:00 GMT Promising Tests of a Vaccine against Chikungunya virus https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/promising-tests-of-a-vaccine-against-chikungunya-virus.aspx A team from the CEA François-Jacob Institute has demonstrated the preclinical efficacy of three vaccine candidates against chikungunya. Health & life sciences ; Virus ; Chikungunya general public ; Journalists ; Researchers Jacob Scientific result Tue, 25 Apr 2017 10:00:00 GMT Chikungunya: Pain Caused by the Immune System https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Scientific-News/2017/chikungunya-pain-caused-by-the-immune-system.aspx Joint damage in people infected with chikungunya remains poorly understood. Scientists from the CEA François-Jacob Institute and their partners have identified an actor of the antiviral immune response whose inhibition paradoxically reduces the severity of the symptoms. Infectious diseases ; Chikungunya ; Diagnosis and innovative treatment general public ; Journalists ; Researchers Jacob Scientific result Mon, 13 Mar 2017 11:00:00 GMT Discovery of a gene associated with radiosensitivity and post-radiotherapy complications https://www.cea.fr/drf/ifrancoisjacob/english/Pages/News/Press/2016/Discovery-of-a-gene-associated-with-radiosensitivity-and-post-radiotherapy-complications.aspx ​Scientists at the CEA’s Institute of Cellular and Molecular Radiation Biology, in collaboration with INSERM, Université Paris-Sud, and international partners, have demonstrated a connection between the expression of the TRAIL gene, which plays a role in cell death, and the radiosensitivity of certain human T lymphocytes. Health & life sciences ; Diagnosis and innovative treatment ; Cellular mechanisms Researchers ; general public DRF Press release ; Scientific result Mon, 21 Mar 2016 11:00:00 GMT