You are here : Home > Research Centers and Units > Genoscope > UMR8030 > Organic Chemistry and Biocatalysis Laboratory (LCOB)


Organic Chemistry and Biocatalysis Laboratory (LCOB)


Published on 20 November 2018
Impacts of microplastics and the associated plastisphere on physiological, biochemical, genetic expression and gut microbiota of the filter-feeder amphioxus
Cheng J, Meistertzheim AL, Leistenschneider D, Philip L, Jacquin J, Escande ML, Barbe V, Ter Halle A, Chapron L, Lartaud F, Bertrand S, Escriva H and Ghiglione JF
Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia
Fossey-Jouenne A, Ducrot L, Jongkind E, Elis‚e E, Zaparucha A, Grogan G, Paul C and Vergne-Vaxelaire C
Frontiers in Catalysis 3 (), 1105948, 2023
Mission Tara Microplastics: a holistic set of protocols and data resources for the field investigation of plastic pollution along the land-sea continuum in Europe
Ghiglione JF, Barbe V, Bruzaud S, Burgaud G, Cachot J, Eyheraguibel B, Lartaud F, Ludwig W, Meistertzheim AL, Paul-Pont I, Pesant S, Ter Halle A, Thiebeauld O and Mission Tara Microplastics c
Analysis of the P.ÿlividus sea urchin genome highlights contrasting trends of genomic and regulatory evolution in deuterostomes
Marl‚taz F, Couloux A, Poulain J, Labadie K, Da Silva C, Mangenot S, Noel B, Poustka AJ, Dru P, Pegueroles C, Borra M, Lowe EK, Lhomond G, Besnardeau L, Le Gras S, Ye T, Gavriouchkina D, Russo R, Costa C, Zito F, Anello L, Nicosia A, Ragusa MA, Pascual M, Molina MD, Chessel A, Di Carlo M, Turon X, Copley RR, Exposito J-Y, Martinez P, Cavalieri V, Ben Tabou de Leon S, Croce J, Oliveri P, Matranga V, Di Bernardo M, Morales J, Cormier P, GeneviŠve A-M, Aury JM, Barbe V, Wincker P, Arnone MI, Gache C and Lepage T
Structure and Mutation of the Native Amine Dehydrogenase MATOUAmDH2
Bennett M, Ducrot L, Vergne-Vaxelaire C and Grogan G
Chelonus inanitus bracovirus encodes lineage-specific proteins and truncated immune IkappaB-like factors
Cerqueira de Araujo A, Josse T, Sibut V, Urabe M, Asadullah A, Barbe V, Nakai M, Huguet E, Periquet G and Drezen JM
Biodegradability under marine conditions of bio-based and petroleum-based polymers as substitutes of conventional microparticles
Cheng J, Eyheraguibel B, Jacquin J, Pujo-Pay M, Conan P, Barbe V, Hoypierres J, Deligey G, Halle AT, Bruzaud S, Ghiglione J-F and Meistertzheim A-L
Evidence of coupled autotrophy and heterotrophy on plastic biofilms and its influence on surrounding seawater
Conan P, Philip L, Ortega-Retuerta E, Odobel C, Duran C, Pandin C, Giraud C, Meistertzheim AL, Barbe V, Ter Hall A, Pujo-Pay M and Ghiglione JF
Expanding the substrate scope of native amine dehydrogenases through in silico structural exploration and targeted protein engineering
Ducrot L, Bennett M, Andr‚-Leroux G, Elis‚e E, Marynberg S, Fossey-Jouenne A, Zaparucha A, Grogan G and Vergne-Vaxelaire C
Purification and Characterization of Nit, a Robust Thermostable Nitrilase From Parabukholderia phymatum
Bessonnet T, Mariage A, Petit JL, Pellouin V, Debard A, Zaparucha A, Vergne-Vaxelaire C and de Berardinis V
Biocatalytic Reductive Amination by Native Amine Dehydrogenases to Access Short Chiral Alkyl Amines and Amino Alcohols
Ducrot L, Bennett M, Caparco AA, Champion JA, Bommarius AS, Zaparucha A, Grogan G and Vergne-Vaxelaire C
NAD(P)H-Dependent Enzymes for Reductive Amination: Active Site Description and Carbonyl-Containing Compound Spectrum
Ducrot L, Bennett M, Grogan G and Vergne-Vaxelaire C
Microbial Diversity and Activity During the Biodegradation in Seawater of Various Substitutes to Conventional Plastic Cotton Swab Sticks
Jacquin J, Callac N, Cheng JG, Giraud C, Gorand Y, Denoual C, Pujo-Pay M, Conan P, Meistertzheim AL, Barbe V, Bruzaud S and Ghiglione JF
Nitrilase immobilization and transposition from a micro-scale batch to a continuous process increase the nicotinic acid productivity
Teepakorn C, Zajkoska P, Cwicklinski G, De Berardinis V, Zaparucha A, Nonglaton G and Anxionnaz-Minvielle Z
Metagenomic Mining for Amine Dehydrogenase Discovery
Caparco AA, Pelletier E, Petit JL, Jouenne A, Bommarius BR, de Berardinis V, Zaparucha A, Champion JA, Bommarius AS and Vergne-Vaxelaire C
ATP Regeneration System in Chemoenzymatic Amide Bond Formation with Thermophilic CoA Ligase
Lelievre CM, Balandras M, Petit JL, Vergne-Vaxelaire C and Zaparucha A
XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii
Domergue J, Erdmann D, Fossey-Jouenne A, Petit JL, Debard A, de Berardinis V, Vergne-Vaxelaire C and Zaparucha A
Achiral Hydroxypyruvaldehyde Phosphate as a Platform for Multi-Aldolases Cascade Synthesis of Diuloses and for a Quadruple Acetaldehyde Addition Catalyzed by 2-Deoxyribose-5-Phosphate Aldolases
Laurent V, Helaine V, Vergne-Vaxelaire C, Nauton L, Traikia M, Petit JL, Salanoubat M, de Berardinis V, Lemaire M and Guerard-Helaine C
A family of native amine dehydrogenases for the asymmetric reductive amination of ketones
Mayol O, Bastard K, Beloti L, Frese A, Turkenburg JP, Petit JL, Mariage A, Debard A, Pellouin V, Perret A, de Berardinis V, Zaparucha A, Grogan G and Vergne-Vaxelaire C
Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family
Bastard K, Isabet T, Stura EA, Legrand P and Zaparucha A
Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Fossey-Jouenne A, Vergne-Vaxelaire C and Zaparucha A
Characterization of a thermotolerant ROK-type mannofructokinase from Streptococcus mitis: application to the synthesis of phosphorylated sugars
Vergne-Vaxelaire C, Mariage A, Petit JL, Fossey-Jouenne A, Guerard-Helaine C, Darii E, Debard A, Nepert S, Pellouin V, Lemaire M, Zaparucha A, Salanoubat M and de Berardinis V
Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis
Bastard K, Perret A, Mariage A, Bessonnet T, Pinet-Turpault A, Petit JL, Darii E, Bazire P, Vergne-Vaxelaire C, Brewee C, Debard A, Pellouin V, Besnard-Gonnet M, Artiguenave F, Medigue C, Vallenet D, Danchin A, Zaparucha A, Weissenbach J, Salanoubat M and De Berardinis V
Biocatalytic Approaches towards the Synthesis of Chiral Amino Alcohols from Lysine: Cascade Reactions Combining alpha-Keto Acid Oxygenase Hydroxylation with Pyridoxal Phosphate- Dependent Decarboxylation
Baud D, Peruch O, Saaidi PL, Fossey A, Mariage A, Petit JL, Salanoubat M, Vergne-Vaxelaire C, de Berardinis V and Zaparucha A
Microbial Degradation of a Recalcitrant Pesticide: Chlordecone
Chaussonnerie S, Saaidi PL, Ugarte E, Barbance A, Fossey A, Barbe V, Gyapay G, Bruls T, Chevalier M, Couturat L, Fouteau S, Muselet D, Pateau E, Cohen GN, Fonknechten N, Weissenbach J and Le Paslier D
Asymmetric reductive amination by a wild-type amine dehydrogenase from the thermophilic bacteria Petrotoga mobilis
Mayol O, David S, Darii E, Debard A, Mariage A, Pellouin V, Petit JL, Salanoubat M, de Berardinis V, Zaparucha A and Vergne-Vaxelaire C
Debromokeramadine from the marine sponge Agelas cf. mauritiana: isolation and short regioselective and flexible synthesis
Schroif-Gregoire C, Appenzeller J, Debitus C, Zaparucha A and Al-Mourabit A
Revealing the hidden functional diversity of an enzyme family
Bastard K, Smith AAT, Vergne-Vaxelaire C, Perret A, Zaparucha A, De Melo-Minardi R, Mariage A, Boutard M, Debard A, Lechaplais C, Pelle C, Pellouin V, Perchat N, Petit JL, Kreimeyer A, Medigue C, Weissenbach J, Artiguenave F, De Berardinis V, Vallenet D and Salanoubat M
Synthesis of Mono- and Dihydroxylated Amino Acids with New alpha-Ketoglutarate-Dependent Dioxygenases: Biocatalytic Oxidation of C-H Bonds
Baud D, Saaidi PL, Monfleur A, Harari M, Cuccaro J, Fossey A, Besnard M, Debard A, Mariage A, Pellouin V, Petit JL, Salanoubat M, Weissenbach J, de Berardinis V and Zaparucha A
Large alpha-aminonitrilase activity screening of nitrilase superfamily members: Access to conversion and enantiospecificity by LC-MS
Bordier F, Stam M, Darii E, Tricot S, Fossey A, Rohault J, Debard A, Mariage A, Pellouin V, Petit JL, Perret A, Vallenet D, Salanoubat M, Weissenbach J, Vergne-Vaxelaire C, de Berardinis V and Zaparucha A
Nitrilase Activity Screening on Structurally Diverse Substrates: Providing Biocatalytic Tools for Organic Synthesis
Vergne-Vaxelaire C, Bordier F, Fossey A, Besnard-Gonnet M, Debard A, Mariage A, Pellouin V, Perret A, Petit JL, Stam M, Salanoubat M, Weissenbach J, De Berardinis V and Zaparucha A
Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M and Alzari PM
Journal of Biological Chemistry 286 (31), 27399-27405, 2011
A Novel Acyl-CoA Beta-Transaminase Characterized from a Metagenome
Perret A, Lechaplais C, Tricot S, Perchat N, Vergne C, Pelle C, Bastard K, Kreimeyer A, Vallenet D, Zaparucha A, Weissenbach J and Salanoubat M
PLoS ONE 6 (8), , 2011
Biocatalysis, bioconversion and white technology: tools from the living world for chemistry
Zaparucha A, de Berardinis V and Weissenbach J
Actualite Chimique (353-54), 43-50, 2011
A Conserved Gene Cluster Rules Anaerobic Oxidative Degradation of L-Ornithine
Fonknechten N, Perret A, Perchat N, Tricot S, Lechaplais C, Vallenet D, Vergne C, Zaparucha A, Le Paslier D, Weissenbach J and Salanoubat M
Journal of Bacteriology 191 (9), 3162-3167, 2009
Biomimetically Inspired Short Access to the 2-Aminoimidazole-Fused Tetracyclic a Core of (+/-)-Dibromoagelaspongin
Picon S, Dau ETH, Martin MT, Retailleau P, Zaparucha A and Al-Mourabit A
Organic Letters 11 (12), 2523-2526, 2009
Debromodispacamides B and D: Isolation from the marine sponge Agelas mauritiana and stereoselective synthesis using a biomimetic proline route
Vergne C, Appenzeller J, Ratinaud C, Martin MT, Debitus C, Zaparucha A and Al-Mourabit A
Organic Letters 10 (3), 493-496, 2008