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Published on 12 December 2018


  1. Gasse C, Zaarour M, Noppen S, Abramov M, Marlière P, Liekens S, De Strooper B, Herdewijn P. Modulation of BACE1 activity by chemically modified aptamers. Chembiochem. 2018, 19(7):754-763. doi: 10.1002/cbic.201700461.
  2. Pezo VHassan C, Louis D, Sargueil B, Herdewijn P, Marliere P. Metabolic recruitment and directed evolution of nucleoside triphosphate uptake in Escherichia coli. ACS Synth Biol. 2018, 7(6):1565-1572. doi: 10.1021/acssynbio.8b00048.
  3. Liu C, Cozens C, Jaziri F, Rozenski J, Maréchal A, Dumbre SG, Pezo VMarliere P, Pinheiro VB, Groaz E, Herdewijn P. Phosphonomethyl Oligonucleotides as Backbone Modified Artificial Genetic Polymers.  J Am Chem Soc. 2018, 140:6690-6699. doi: 10.1021/jacs.8b03447.
  4. Jabgunde AM, Jaziri F, Bande O, Froeyen M, Abramov M, Nguyen H, Schepers G, Lescrinier E, Pinheiro VB, Pezo V, Marlière P, Herdewijn P. Methylated nucleobases: Synthesis and evaluation for base pairing in vitro and in vivo. Chemistry 2018, 24:12695-12707. doi: 10.1002/chem.201802304.
  5. de Lorenzo V, Marlière P. The Synthetic Microbiology Caucus: a fresh channel for exploring new ideas, challenging conventional wisdom and fostering community projects.  Microb Biotechnol.
    2018, Oct 25. doi: 10.1111/1751-7915.13331. [Epub ahead of print]


  1. Eremeeva E, Abramov M, Margamuljana L, Herdewijn P.  Base-Modified Nucleic Acids as a Powerful Tool for Synthetic Biology and Biotechnology.  Chemistry 2017, 23(40):9560-9576. doi: 10.1002/chem.201700679.
  2. Kuenzl T, Sroka M, Srivastava P, Herdewijn P, Marlière P, Panke S. Overcoming the membrane barrier: Recruitment of γ-glutamyl transferase for intracellular release of metabolic cargo from peptide vectors.  Metab Eng., 2017, 39:60-70. doi: 10.1016/j.ymben.2016.10.016.
  3. Singh V, Braddick D, Dhar PK. Exploring the potential of genome editing CRISPR-Cas9 technology. Gene, 2017, 599:1-18. doi: 10.1016/j.gene.2016.11.008. Review.
  4. Röthlisberger P, Levi-Acobas F, Sarac I, Marlière P, Herdewijn P, Hollenstein M.  On the enzymatic incorporation of an imidazole nucleotide into DNA.  Org Biomol Chem., 2017, 15(20):4449-4455. doi: 10.1039/c7ob00858a.
  5. Bouzon M, Perret A, Loreau O, Delmas V, Perchat N, Weissenbach J, Taran F, Marlière P.  A Synthetic Alternative to Canonical One-Carbon Metabolism. ACS Synth Biol. 2017, 6(8):1520-1533. doi: 10.1021/acssynbio.7b00029.
  6. Röthlisberger P, Levi-Acobas F, Sarac I, Baron B, England P, Marlière P, Herdewijn P, Hollenstein M. Facile immobilization of DNA using an enzymatic his-tag mimic.  Chem Commun (Camb). 2017, Nov 22. doi: 10.1039/c7cc07207d. 
  7. Röthlisberger P, Gasse C, Hollenstein M. Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery. Int J Mol Sci. 2017, 18(11). pii: E2430. doi: 10.3390/ijms18112430.


  1. Bande O, Braddick D, Agnello S, Jang M, Pezo V, Schepers G, Rozenski J, Lescrinier E, Marliere P, Herdewijn P. Base pairing involving artificial bases in vitro and in vivo. Chemical Science, 2016, 7:995–1010.
  2. Eremeeva E, Abramov M, Margamuljana L, Rozenski J, Pezo VMarlière P, Herdewijn P.  Chemical Morphing of DNA Containing Four Noncanonical Bases.  Angew Chem Int Ed Engl., 2016, 55(26):7515-7519. doi: 10.1002/anie.201601529.
  3. Taylor AI, Beuron F, Peak-Chew S-Y, Morris EP, Herdewijn P, Holliger P. Nanostructures from synthetic genetic polymers. ChemBioChem, 2016, 17:1107–1110.
  4. de Lorenzo V, Marlière P, Solé R. Bioremediation at a global scale: from the test tube to planet Earth.  Microb Biotechnol. 2016, 9(5):618-25. doi: 10.1111/1751-7915.12399.
  5. Eremeeva E, Abramov M, Marlière P, Herdewijn P.  The 5-chlorouracil:7-deazaadenine base pair as an alternative to the dT:dA base pair. Org Biomol Chem. 2016, 15(1)168-176. 



  1. Taylor AI, Pinheiro VB, Smola MJ, Morgunov AS, Peak-Chew S, Cozens C, Weeks KM, Herdewijn P, Holliger P.  Catalysts from synthetic genetic polymers. Nature. 2015, 518(7539):427-430. doi: 10.1038/nature1398
  2. Bande O, Abu El Asrar R, Braddick D, Dumbre S, Pezo V, Schepers G, Pinheiro VB, Lescrinier E, Holliger P, Marlière PHerdewijn P. Isoguanine and 5-methyl-isocytosine bases, in vitro and in vivo. Chemistry. 2015, 21(13):5009-5022. doi: 10.1002/chem.201406392.
  3. De S, Groaz E, Margamuljana L, Abramov M, Marlière PHerdewijn P. Sulfonate derived phosphoramidates as active intermediates in the enzymatic primer-extension of DNA. Org. Biomol. Chem., 2015, 13(13):3950-3962. doi: 10.1039/c5ob00157a.
  4. Singh V, Braddick D. Recent advances and versatility of MAGE towards industrial applications.  Syst. Synth. Biol. 2015 Dec;9(Suppl 1):1-9. doi: 10.1007/s11693-015-9184


  1. Pezo V, Schepers G, Lambertucci C, Marlière P, Herdewijn P. Probing Ambiguous Base-Pairs by Genetic Transformation with XNA Templates. ChemBioChem 2014, 15(15):2255-2258. NDOI: 10.1002/cbic.201402226.
  2. De S, Groaz E, Maiti M, Pezo V, Marlière P, Herdewijn P. Synthesis of new biocarrier-nucleotide systems for cellular delivery in bacterial auxotrophic strains. Tetrahedron 2014, 70:8843-8851.



  1. Pezo V, Louis D, Guérineau V, Le Caer JP, Gaillon L, Mutzel R, Marlière P. A metabolic prototype for eliminating tryptophan from the genetic code.  Sci Rep. 2013, 3:1359.
  2. Pezo V, Liu FW, Abramov M, Froeyen M, Herdewijn P, Marlière P. Binary Genetic Cassettes for Selecting XNA-Templated DNA Synthesis In Vivo.  Angew Chem. Int. Ed. Engl. 2013, 52(31):8139-8143. doi: 10.1002/anie.201303288.