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SysFate - Systems Biology of cell Fate decisions


Published on 8 July 2022

​Our team aims at reconstituting the spatio-temporal gene regulatory programs implicated in brain organogenesis, by combining the recent advances in induced-pluripotent stem cell (iPSC) technology, as well as in 3-dimensional cerebral organoid culturing procedures, able to reconstitute brain structures in-vitro. For it, the acquisition of functional genomics readouts in a spatio-temporal context and their integration by the use of computational strategies will allow to enhance our understanding of the cell fate trajectories, defining the complexity of the system.