The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
PET and radiochemistry
High-resolution imaging techniques and multinuclear (13C and 31P) spectroscopy are being developed and validated with a 7T magnet:
Examinations can be carried out on rodents and primates in biosafety level 1, 2 or 3 confinement. The magnet is sealed in a hermetic sarcophagus, making it possible to carry out maintenance interventions on the magnet in confinement conditions.
The expertise of MIRCen in the domain of PET imaging covers the following strategic axes:
validation of radiotracers in validated animal models of human diseases.
validation of animal models by PET with validated radiotracers.
The PET platform also works closely with the NMR and histology platforms for the three-dimensional reconstruction of multimodal images (Image Processing platform).
PET imaging system for rodents
The PET platform currently houses:
The radiochemistry platform allows the radiosynthesis and the development of new radiotracers specific to biological targets involved in a pathological process. Labeling concerns little molecules (molecular weight < 500 Da) and macromolecules (molecular weight > 500 Da) also. The future in house cyclotron will produce the 2 short half-life radioisotopes
18F (20.4 and 109.8 minutes respectively):
Since the opening of MIRCen, PET tracers have been radiolabeled at the Radiochemistry Laboratory of Frédéric Joliot Hospital, with a biomedical cyclotron and dedicated synthesizers housed in ventilated, shielded areas, according to current regulations. The future new radiochemistry infrastructure will make use of the same facilities.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.