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A 2 to 3-years post-doctoral position is available in the laboratory of hematopoietic stem cells and leukaemia in the Institute of Cellular and Molecular Radiobiology, also UMR INSERM/CEA/Universities Paris Diderot/Paris Sud, in Fontenay-aux-Roses under the supervision of Dr Françoise Pflumio. This position is supported by a grant from the French Cancer Institute (INCA), and can start in early 2019. We are looking for a highly motivated young scientist that would be interested to join a research program devoted to study the role of several oncogenic fusions, starting with ETO2-GLIS2, in human paediatric leukaemia. The project will necessitate to work with human hematopoietic stem/progenitor cells from different ontogeny origin. It will be developed in close collaboration with the team of Dr Thomas Mercher from Gustave Roussy Institute, in Villejuif, France.
The candidate will show solid knowledge in cellular and molecular biology and have a PhD diploma, in relation to onco/haematology. Strong knowledge of the human hematopoietic hierarchy is mandatory to understand, design and perform the experiments necessary in the project. Technical skills in cell culture, multiparameter flow cytometry (analyses and cell sorting) and molecular biology are important to work on the project. The candidate will have knowledge and skills in animal experimentation, in particular in mouse transplantation. He/she needs to be autonomous in his/her research work, and to be able to work with the other members of the team, including students. English language has to be fluent in terms of writing and discussing results.
The lab is located nearby Paris, easily accessible using public transportation and is part of the Cellular and Molecular Biology Institute of Commissariat à l'Energie Atomique et Energies Alternatives. We have all the necessary technical platforms to successfully develop this project (flow cytometry, animal colony comprising immune-deficient mice, irradiation facilities, confocal microscopy, molecular biology platform, …). Proximity to other Parisian Institutes facilitates technical exchanges.
Interested candidates should send a CV, with a motivation lettre and two references (email addresses) to:
The team will welcome 2 Master 1 students and one student in "contrat d'alternance" in 2019.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.