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Iron(II)/α-ketoacid-dependent oxygenases (αKAOs) are enzymes that catalyze the oxidation of unactivated C-H bonds, mainly through hydroxylation.
Our results strongly suggest that the substrate specificity and high stereoselectivity observed in this family are related to two structural characteristics: a flexible loop (lid) and a sub-pocket, when closed, the lid forms a sub-pocket around the substrate side chain. This dynamic cover is found throughout the family with a variable sequence and length and is associated with a stable and preserved dimeric interface.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.