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Publications du STI

Publié le 19 octobre 2017

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Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.
Prel A, Caval V, Gayon R, Ravassard P, Duthoit C, Payen E, Maouche-Chretien L, Creneguy A, Nguyen TH, Martin N, Piver E, Sevrain R, Lamouroux L, Leboulch P, Deschaseaux F, Bouille P, Sensebe L, Pages JC.
Molecular therapy Methods & clinical development Oct 21 (2), 15039, 2015
Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of beta-thalassemia and sickle cell disease.
Negre O, Bartholomae C, Beuzard Y, Cavazzana M, Christiansen L, Courne C, Deichmann A, Denaro M, de Dreuzy E, Finer M, Fronza R, Gillet-Legrand B, Joubert C, Kutner R, Leboulch P, Maouche L, Paulard A, Pierciey FJ, Rothe M, Ryu B, Schmidt M, von Kalle C, Payen E, Veres G.
Current gene therapy (15(1)), 64-81, 2015
Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice
Soumeya A, Tubsuwan A, Chaichompoo P, Park I, Pailleret A, Benyoucef A, Tosca L, De Dreuzy E, Paulard A, Granger-Locatelli M, Relouzat F, Prost S, Tachdjian G, Fucharoen S, Daley GQ, Payen E, Chrétien S, Leboulch P, Maouche-Chrétien L.
Haematologica Oct (10), 428-31, 2015
Erosion of the chronic myeloid leukaemia stem cell pool by PPARgamma agonists
Prost S, Relouzat F, Spentchian M, Ouzegdouh Y, Saliba J1 Massonnet G, Beressi JP, Verhoeyen E, Raggueneau V, Maneglier B, Castaigne S,Chomienne C, Chrétien S, Rousselot P, Leboulch P
Nature Sep 17 (525(7569)), 380-3, 2015
Erythropoietin and IGF-1 signaling synchronize cell proliferation and maturation during erythropoiesis
Kadri Z, Lefevre C, Goupille O, Penglong T, Granger-Locatelli M, Fucharoen S, Maouche-Chretien L, Leboulch P, Chretien S
Genes Dev Dec 15 (29(24)), 2603-16, 2015
HSP70 sequestration by free alpha-globin promotes ineffective erythropoiesis in beta-thalassaemia
Arlet JB, Ribeil JA, Guillem F, Negre O, Hazoume A, Marcion G, Beuzard Y, Dussiot M, Moura IC, Demarest S, de Beauchene IC, Belaid-Choucair Z, Sevin M, Maciel TT, Auclair C, Leboulch P, Chretien S, Tchertanov L, Baudin-Creuza V, Seigneuric R, Fontenay M, Garrido C, Hermine O, Courtois G
Nature 514 (7521), 242-246, 2014
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics
Grosselin J, Sii-Felice K, Payen E, Chretien S, Roux DT, Leboulch P
Stem Cells 31 (10), 2162-2171, 2013
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in beta-thalassemia
Dussiot M, Maciel TT, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, Leboulch P, Ribeil JA, Arlet JB, Cote F, Courtois G, Ginzburg YZ, Daniel TO, Chopra R, Sung V, Hermine O, Moura IC
Nat. Med. 20 (4), 398-+, 2014
Loss of Major Molecular Response As a Trigger for Restarting Tyrosine Kinase Inhibitor Therapy in Patients With Chronic-Phase Chronic Myelogenous Leukemia Who Have Stopped Imatinib After Durable Undetectable Disease
Rousselot P, Charbonnier A, Cony-Makhoul P, Agape P, Nicolini FE, Varet B, Gardembas M, Etienne G, Rea D, Roy L, Escoffre-Barbe M, Guerci-Bresler A, Tulliez M, Prost S, Spentchian M, Cayuela JM, Reiffers J, Chomel JC, Turhan A, Guilhot J, Guilhot F, Mahon FX
J. Clin. Oncol. 32 (5), 424-U59, 2014
BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7
Goupille O, Penglong T, Lefevre C, Granger M, Kadri Z, Fucharoen S, Maouche-Chretien L, Leboulch P, Chretien S
Biochem. Biophys. Res. Commun. 429 (1-2), 1-5, 2012
Advances in stem cell transplantation and gene therapy in the beta-hemoglobinopathies
Payen E, Leboulch P
Hematol.-Am. Soc. Hematol. Educ. Program , 276-283, 2012
GENE THERAPY Primed for take-off
Leboulch P
Nature 500 (7462), 280-282, 2013
Parallel Assessment of Globin Lentiviral Transfer in Induced Pluripotent Stem Cells and Adult Hematopoietic Stem Cells Derived from the Same Transplanted beta-Thalassemia Patient
Tubsuwan A, Abed S, Deichmann A, Kardel MD, Bartholoma C, Cheung A, Negre O, Kadri Z, Fucharoen S, von Kalle C, Payen E, Chretien S, Schmidt M, Eaves CJ, Leboulch P, Maouche-Chretien L
Stem Cells 31 (9), 1785-1794, 2013
Stem Cell Factor-Displaying Simian Immunodeficiency Viral Vectors Together with a Low Conditioning Regimen Allow for Long-Term Engraftment of Gene-Marked Autologous Hematopoietic Stem Cells in Macaques
Verhoeyen E, Relouzat F, Cambot M, Costa C, Negre D, Legrand F, Joubert C, Le Grand R, Cosset FL, Leboulch P, Dubart-Kupperschmitt A, Prost S
Hum. Gene Ther. 23 (7), 754-768, 2012
LENTIVIRUS VECTORS IN beta-THALASSEMIA
Payen E, Colomb C, Negre O, Beuzard Y, Hehir K, Leboulch P
Methods Enzymol. 507, 109-124, 2012
Deficiency of the Cytoskeletal Protein SPECC1L Leads to Oblique Facial Clefting
Saadi I, Alkuraya F S, Gisselbrecht S S, Goessling W, Cavallesco R, Turbe-Doan A, Petrin A L, Harris J, Siddiqui U, Grix A W, Hove H D, Leboulch P, Glover T W, Morton C C, Richieri-Costa A, Murray J C, Erickson R P, Maas R L
AMERICAN JOURNAL OF HUMAN GENETICS 89 (1), 44-55, 2011
Is normal hematopoiesis maintained solely by long-term multipotent stem cells?
Cavazzana-Calvo M, Fischer A, Bushman F D, Payen E, Hacein-Bey-Abina S, Leboulch P
Blood 117 (17), 4420-4424, 2011
A method to sequence and quantify DNA integration for monitoring outcome in gene therapy
Brady T, Roth S L, Malani N, Wang G P, Berry C C, Leboulch P, Hacein-Bey-Abina S, Cavazzana-Calvo M, Papapetrou E P, Sadelain M, Savilahti H, Bushman F D
Nucleic Acids Res. 39 (11), e72, 2011
Correction of murine {beta}-thalassemia after minimal lentiviral gene transfer and homeostatic in vivo erythroid expansion
Negre O, Fusil F, Colomb C, Roth S, Gillet-Legrand B, Henri A, Beuzard Y, Bushman F, Leboulch P, Payen E
Blood 117 (20), 5321-5331, 2011
Distribution of Lentiviral Vector Integration Sites in Mice Following Therapeutic Gene Transfer to Treat beta-thalassemia
Ronen K, Negre O, Roth S, Colomb C, Malani N, Denaro M, Brady T, Fusil F, Gillet-Legrand B, Hehir K, Beuzard Y, Leboulch P, Down J D, Payen E, Bushman F D
MOLECULAR THERAPY 19 (7), 1273-1286, 2011
Mouse models of sickle cell disease
Beuzard Y
TRANSFUSION CLINIQUE ET BIOLOGIQUE 15 (1-2), 7-11, 2008
Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial
Wang G P, Berry C C, Malani N, Leboulch P, Fischer A, Hacein-Bey-Abina S, Cavazzana-Calvo M, Bushman F D
Blood 115 (22), 4356-4366, 2010
Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassaemia
Cavazzana-Calvo M, Payen E, Negre O, Wang G, Hehir K, Fusil F, Down J, Denaro M, Brady T, Westerman K, Cavallesco R, Gillet-Legrand B, Caccavelli L, Sgarra R, Maouche-Chretien L, Bernaudin F, Girot R, Dorazio R, Mulder G J, Polack A, Bank A, Soulier J, Larghero J, Kabbara N, Dalle B, Gourmel B, Socie G, Chretien S, Cartier N, Aubourg P, Fischer A, Cornetta K, Galacteros F, Beuzard Y, Gluckman E, Bushman F, Hacein-Bey-Abina S, Leboulch P
Nature 467 (7313), 318-U94, 2010
Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy
Cartier N, Hacein-Bey-Abina S, Bartholomae C C, Veres G, Schmidt M, Kutschera I, Vidaud M, Abel U, Dal-Cortivo L, Caccavelli L, Mahlaoui N, Kiermer V, Mittelstaedt D, Bellesme C, Lahlou N, Lefrere F, Blanche S, Audit M, Payen E, Leboulch P, l'Homme B, Bougneres P, von Kalle C, Fischer A, Cavazzana-Calvo M, Aubourg P
Science 326 (5954), 818-823, 2009
Gfi-1B Promoter Remains Associated with Active Chromatin Marks Throughout Erythroid Differentiation of Human Primary Progenitor Cells
Laurent B, Randrianarison-Huetz V, Kadri Z, Romeo P H, Porteu F, Dumenil D
Stem Cells 27 (9), 2153-2162, 2009
Phenotypic and Functional Changes Induced in Hematopoietic Stem/Progenitor Cells After Gamma-Ray Radiation Exposure
Simonnet A J, Nehme J, Vaigot P, Barroca V, Leboulch P, Tronik-Le Roux D
Stem Cells 27 (6), 1400-1409, 2009
Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis
Kadri Z, Shimizu R, Ohneda O, Maouche-Chretien L, Gisselbrecht S, Yamamoto M, Romeo P H, Leboulch P, Chretien S
PLOS BIOLOGY 7 (6), e1000123, 2009
Activation and inhibition of the erythropoietin receptor by a membrane-anchored erythropoietin
Negre O, Fusil F, Henri A, Villette JM, Leboulch P, Beuzard Y, Payen E
EXPERIMENTAL HEMATOLOGY 36 (4), 412-423, 2008